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http://dx.doi.org/10.3340/jkns.2016.59.5.529

Treatment for Acute Stage Complex Regional Pain Syndrome Type II with Polydeoxyribonucleotide Injection  

Jang, Kun Soo (Department of Neurosurgery, SunHan Hospital)
Kim, Hyeun Sung (Department of Neurosurgery, SunHan Hospital)
Publication Information
Journal of Korean Neurosurgical Society / v.59, no.5, 2016 , pp. 529-532 More about this Journal
Abstract
Complex regional pain syndrome (CRPS) type II is a syndrome that develops after nerve injury. Symptoms may be severe, and vary depending on the degree of sympathetic nerve involvement. As yet, there is no satisfactory treatment. We report the case of a female patient who had an L5 left transverse process fracture and an S2 body fracture, who developed symptoms of CRPS type II in her left lower leg that were aggravated during ambulation in spite of absolute bed rest for one month after the trauma. Several treatments, including bed rest, medication, and numerous nerve blocks were attempted, but the pain persisted. We finally tried injection of polydeoxyribonucleotide (PDRN) solution at the left L5 transverse process fracture site because we knew of the anti-inflammatory effect of PDRN. One day after this treatment, her symptoms had almost disappeared and three days later, she was discharged. We will also further discuss the possibility of using PDRN solution for the treatment of CRPS.
Keywords
Complex regional pain syndrome; Polydeoxyribonucleotides;
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