Sildenafil Ameliorates Advanced Glycation End Products-Induced Mitochondrial Dysfunction in HT-22 Hippocampal Neuronal Cells |
Sung, Soon Ki
(Department of Neurosurgery, Pusan National University School of Medicine)
Woo, Jae Suk (Department of Physiology, Pusan National University School of Medicine) Kim, Young Ha (Department of Neurosurgery, Pusan National University School of Medicine) Son, Dong Wuk (Department of Neurosurgery, Pusan National University School of Medicine) Lee, Sang Weon (Department of Neurosurgery, Pusan National University School of Medicine) Song, Geun Sung (Department of Neurosurgery, Pusan National University School of Medicine) |
1 | Choi DE, Jeong JY, Lim BJ, Chung S, Chang YK, Lee SJ, et al. : Pretreatment of sildenafil attenuates ischemia-reperfusion renal injury in rats. Am J Physiol Renal Physiol 297 : F362-F370, 2009 DOI |
2 | Dar TA, Sheikh IA, Ganie SA, Ali R, Singh LR, Gan SH, et al. : Molecular linkages between diabetes and Alzheimer's disease : current scenario and future prospects. CNS Neurol Disord Drug Targets 13 : 290-298, 2014 DOI |
3 | Gaens KH, Stehouwer CD, Schalkwijk CG : Advanced glycation endproducts and its receptor for advanced glycation endproducts in obesity. Curr Opin Lipidol 24 : 4-11, 2013 DOI |
4 | Ghofrani HA, Osterloh IH, Grimminger F : Sildenafil : from angina to erectile dysfunction to pulmonary hypertension and beyond. Nat Rev Drug Discov 5 : 689-702, 2006 DOI |
5 | Hotston MR, Jeremy JY, Bloor J, Koupparis A, Persad R, Shukla N : Sildenafil inhibits the up-regulation of phosphodiesterase type 5 elicited with nicotine and tumour necrosis factor-alpha in cavernosal vascular smooth muscle cells : mediation by superoxide. BJU Int 99 : 612-618, 2007 DOI |
6 | IDF Diabetes Atlas Group : Update of mortality attributable to diabetes for the IDF Diabetes Atlas : estimates for the year 2011. Diabetes Res Clin Pract 100 : 277-279, 2013 DOI |
7 | Vlassara H, Striker GE : AGE restriction in diabetes mellitus : a paradigm shift. Nat Rev Endocrinol 7 : 526-539, 2011 DOI |
8 | Jeremy JY, Koupparis A, Muzaffar S, Persad R, Angelini GD, Shukla N : Is the therapeutic action of sildenafil mediated partly through the inhibition of superoxide formation? BJU Int 95 : 930-931, 2005 DOI |
9 | Yu T, Robotham JL, Yoon Y : Increased production of reactive oxygen species in hyperglycemic conditions requires dynamic change of mitochondrial morphology. Proc Natl Acad Sci U S A 103 : 2653-2658, 2006 DOI |
10 | Jackson G, Gillies H, Osterloh I : Past, present, and future : a 7-year update of Viagra (sildenafil citrate). Int J Clin Pract 59 : 680-691, 2005 DOI |
11 | Lemasters JJ, Nieminen AL, Qian T, Trost LC, Elmore SP, Nishimura Y, et al. : The mitochondrial permeability transition in cell death : a common mechanism in necrosis, apoptosis and autophagy. Biochim Biophys Acta 1366 : 177-196, 1998 DOI |
12 | Kawahara G, Gasperini MJ, Myers JA, Widrick JJ, Eran A, Serafini PR, et al. : Dystrophic muscle improvement in zebrafish via increased heme oxygenase signaling. Hum Mol Genet 23 : 1869-1878, 2014 DOI |
13 | Kodl CT, Seaquist ER : Cognitive dysfunction and diabetes mellitus. Endocr Rev 29 : 494-511, 2008 DOI |
14 | Konstantinopoulos A, Giannitsas K, Athanasopoulos A, Spathas D, Perimenis P : The impact of daily sildenafil on levels of soluble molecular markers of endothelial function in plasma in patients with erectile dysfunction. Expert Opin Pharmacother 10 : 155-160, 2009 DOI |
15 | Liu XM, Peyton KJ, Wang X, Durante W : Sildenafil stimulates the expression of gaseous monoxide-generating enzymes in vascular smooth muscle cells via distinct signaling pathways. Biochem Pharmacol 84 : 1045-1054, 2012 DOI |
16 | Lyman GE, DeVincenzo JP : Determination of picogram amounts of ATP using the luciferin-luciferase enzyme system. Anal Biochem 21 : 435-443, 1967 DOI |
17 | Marks GS : Heme oxygenase : the physiological role of one of its metabolites, carbon monoxide and interactions with zinc protoporphyrin, cobalt protoporphyrin and other metalloporphyrins. Cell Mol Biol (Noisy-le-grand) 40 : 863-870, 1994 |
18 | Mijnhout GS, Scheltens P, Diamant M, Biessels GJ, Wessels AM, Simsek S, et al. : Diabetic encephalopathy : a concept in need of a definition. Diabetologia 49 : 1447-1448, 2006 DOI |
19 | Aziz MT, Mostafa T, Atta H, Rashed L, Marzouk SA, Obaia EM, et al. : The role of PDE5 inhibitors in heme oxygenase-cGMP relationship in rat cavernous tissues. J Sex Med 5 : 1636-1645, 2008 DOI |
20 | Abdel Aziz MT, El-Asmer MF, Mostafa T, Mostafa S, Atta H, Aziz Wassef MA, et al. : Heme oxygenase vs. nitric oxide synthase in signaling mediating sildenafil citrate action. J Sex Med 4 (4 Pt 2) : 1098-1107, 2007 DOI |
21 | Morgan DM : Tetrazolium (MTT) assay for cellular viability and activity. Methods Mol Biol 79 : 179-183, 1998 |
22 | Muzaffar S, Shukla N, Jeremy JY : Nicotinamide adenine dinucleotide phosphate oxidase : a promiscuous therapeutic target for cardiovascular drugs? Trends Cardiovasc Med 15 : 278-282, 2005 DOI |
23 | Negi G, Kumar A, Kaundal RK, Gulati A, Sharma SS : Functional and biochemical evidence indicating beneficial effect of Melatonin and Nicotinamide alone and in combination in experimental diabetic neuropathy. Neuropharmacology 58 : 585-592, 2010 DOI |
24 | Neuzil J, Stocker R : Bilirubin attenuates radical-mediated damage to serum albumin. FEBS Lett 331 : 281-284, 1993 DOI |
25 | Neuzil J, Stocker R : Free and albumin-bound bilirubin are efficient co-antioxidants for alpha-tocopherol, inhibiting plasma and low density lipoprotein lipid peroxidation. J Biol Chem 269 : 16712-16719, 1994 |
26 | Oates PJ : Aldose reductase, still a compelling target for diabetic neuropathy. Curr Drug Targets 9 : 14-36, 2008 DOI |
27 | Piperi C, Adamopoulos C, Dalagiorgou G, Diamanti-Kandarakis E, Papavassiliou AG : Crosstalk between advanced glycation and endoplasmic reticulum stress : emerging therapeutic targeting for metabolic diseases. J Clin Endocrinol Metab 97 : 2231-2242, 2012 DOI |
28 | Brownlee M : Biochemistry and molecular cell biology of diabetic complications. Nature 414 : 813-820, 2001 DOI |
29 | Aziz MT, Al-Asmar MF, Mostafa T, Atta H, Rashed L, Sabry D, et al. : Assessment of heme oxygenase-1 (HO-1) activity in the cavernous tissues of sildenafil citrate-treated rats. Asian J Androl 9 : 377-381, 2007 DOI |
30 | Beal MF : Mitochondrial dysfunction in neurodegenerative diseases. Biochim Biophys Acta 1366 : 211-223, 1998 DOI |
31 | Burnett AL, Strong TD, Trock BJ, Jin L, Bivalacqua TJ, Musicki B : Serum biomarker measurements of endothelial function and oxidative stress after daily dosing of sildenafil in type 2 diabetic men with erectile dysfunction. J Urol 181 : 245-251, 2009 |
32 | Rashid A : The efficacy and safety of PDE5 inhibitors. Clin Cornerstone 7 : 47-56, 2005 DOI |
33 | Pop-Busui R, Marinescu V, Van Huysen C, Li F, Sullivan K, Greene DA, et al. : Dissection of metabolic, vascular, and nerve conduction interrelationships in experimental diabetic neuropathy by cyclooxygenase inhibition and acetyl-L-carnitine administration. Diabetes 51 : 2619-2628, 2002 DOI |
34 | Pun PB, Murphy MP : Pathological significance of mitochondrial glycation. Int J Cell Biol 2012 : 843505, 2012 |
35 | Purves T, Middlemas A, Agthong S, Jude EB, Boulton AJ, Fernyhough P, et al. : A role for mitogen-activated protein kinases in the etiology of diabetic neuropathy. FASEB J 15 : 2508-2514, 2001 DOI |
36 | Puzzo D, Loreto C, Giunta S, Musumeci G, Frasca G, Podda MV, et al. : Effect of phosphodiesterase-5 inhibition on apoptosis and beta amyloid load in aged mice. Neurobiol Aging 35 : 520-531, 2014 DOI |
37 | Puzzo D, Staniszewski A, Deng SX, Privitera L, Leznik E, Liu S, et al. : Phosphodiesterase 5 inhibition improves synaptic function, memory, and amyloid-beta load in an Alzheimer's disease mouse model. J Neurosci 29 : 8075-8086, 2009 DOI |
38 | Choei H, Sasaki N, Takeuchi M, Yoshida T, Ukai W, Yamagishi S, et al. : Glyceraldehyde-derived advanced glycation end products in Alzheimer's disease. Acta Neuropathol 108 : 189-193, 2004 |
39 | Cadirci E, Halici Z, Odabasoglu F, Albayrak A, Karakus E, Unal D, et al. : Sildenafil treatment attenuates lung and kidney injury due to overproduction of oxidant activity in a rat model of sepsis : a biochemical and histopathological study. Clin Exp Immunol 166 : 374-384, 2011 DOI |
40 | Chen J : Heme oxygenase in neuroprotection : from mechanisms to therapeutic implications. Rev Neurosci 25 : 269-280, 2014 |
41 |
Shimizu F, Sano Y, Tominaga O, Maeda T, Abe MA, Kanda T : Advanced glycation end-products disrupt the blood-brain barrier by stimulating the release of transforming growth factor- |
42 | Rolo AP, Palmeira CM : Diabetes and mitochondrial function : role of hyperglycemia and oxidative stress. Toxicol Appl Pharmacol 212 : 167-178, 2006 DOI |
43 | Sandireddy R, Yerra VG, Areti A, Komirishetty P, Kumar A : Neuroinflammation and oxidative stress in diabetic neuropathy : futuristic strategies based on these targets. Int J Endocrinol 2014 : 674987, 2014 |
44 | Schmidt AM, Yan SD, Yan SF, Stern DM : The biology of the receptor for advanced glycation end products and its ligands. Biochim Biophys Acta 1498 : 99-111, 2000 DOI |
45 | Sima AA : Encephalopathies : the emerging diabetic complications. Acta Diabetol 47 : 279-293, 2010 DOI |
46 | Takeuchi M, Yamagishi S : Possible involvement of advanced glycation end-products (AGEs) in the pathogenesis of Alzheimer's disease. Curr Pharm Des 14 : 973-978, 2008 DOI |
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