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http://dx.doi.org/10.3340/jkns.2015.57.4.303

Deep Brain Stimulation of the Subthalamic and Pedunculopontine Nucleus in a Patient with Parkinson's Disease  

Liu, Huan-Guang (Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University)
Zhang, Kai (Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University)
Yang, An-Chao (Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University)
Zhang, Jian-Guo (Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University)
Publication Information
Journal of Korean Neurosurgical Society / v.57, no.4, 2015 , pp. 303-306 More about this Journal
Abstract
Deep brain stimulation (DBS) of the pedunculopontine nucleus (PPN) is a novel therapy developed to treat Parkinson's disease. We report a patient who underwent bilateral DBS of the PPN and subthalamic nucleus (STN). He suffered from freezing of gait (FOG), bradykinesia, rigidity and mild tremors. The patient underwent bilateral DBS of the PPN and STN. We compared the benefits of PPN-DBS and STN-DBS using motor and gait subscores. The PPN-DBS provided modest improvements in the gait disorder and freezing episodes, while the STN-DBS failed to improve the dominant problems. This special case suggests that PPN-DBS may have a unique role in ameliorating the locomotor symptoms and has the potential to provide improvement in FOG.
Keywords
Deep brain stimulation; Pedunculopontine nucleus; Subthalamic nucleus; Parkinson's disease;
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