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http://dx.doi.org/10.3340/jkns.2015.57.2.82

Impaired Voluntary Wheel Running Behavior in the Unilateral 6-Hydroxydopamine Rat Model of Parkinson's Disease  

Pan, Qi (Department of Neurosurgery, Zhujiang Hospital, Southern Medical University)
Zhang, Wangming (Department of Neurosurgery, Zhujiang Hospital, Southern Medical University)
Wang, Jinyan (Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences)
Luo, Fei (Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences)
Chang, Jingyu (Neuroscience Research Institute of North Carolina)
Xu, Ruxiang (Department of Neurosurgery, Zhujiang Hospital, Southern Medical University)
Publication Information
Journal of Korean Neurosurgical Society / v.57, no.2, 2015 , pp. 82-87 More about this Journal
Abstract
Objective : The aim of this study was to investigate voluntary wheel running behavior in the unilateral 6-hydroxydopamine (6-OHDA) rat model. Methods : Male Sprague-Dawley rats were assigned to 2 groups : 6-OHDA group (n=17) and control group (n=8). The unilateral 6-OHDA rat model was induced by injection of 6-OHDA into unilateral medial forebrain bundle using a stereotaxic instrument. Voluntary wheel running activity was assessed per day in successfully lesioned rats (n=10) and control rats. Each behavioral test lasted an hour. The following parameters were investigated during behavioral tests : the number of running bouts, the distance moved in the wheel, average peak speed in running bouts and average duration from the running start to the peak speed. Results : The number of running bouts and the distance moved in the wheel were significantly decreased in successfully lesioned rats compared with control rats. In addition, average peak speed in running bouts was decreased, and average duration from the running start to the peak speed was increased in lesioned animals, which might indicate motor deficits in these rats. These behavioral changes were still observed 42 days after lesion. Conclusion : Voluntary wheel running behavior is impaired in the unilateral 6-OHDA rat model and may represent a useful tool to quantify motor deficits in this model.
Keywords
Parkinson's disease; Voluntary wheel running behavior; 6-hydroxydopamine; Medial forebrain bundle; Rat;
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1 Bromberg-Martin ES, Matsumoto M, Hikosaka O. Dopamine in motivational control : rewarding, aversive, and alerting. Neuron 68 : 815-834, 2010   DOI
2 Rhodes JS, Gammie SC, Garland T Jr : Neurobiology of Mice Selected for High Voluntary Wheel-running Activity. Integr Comp Biol 45 : 438-455, 2005   DOI
3 Kasahara T, Kubota M, Miyauchi T, Noda Y, Mouri A, Nabeshima T, et al. : Mice with neuron-specific accumulation of mitochondrial DNA mutations show mood disorder-like phenotypes. Mol Psychiatry 11 : 577-593, 523, 2006   DOI
4 Nakata Y, Yasuda T, Mochizuki H : Recent progress in gene therapy for Parkinson's disease. Curr Mol Med 12 : 1311-1318, 2012   DOI
5 Chang JY, Shi LH, Luo F, Woodward DJ : High frequency stimulation of the subthalamic nucleus improves treadmill locomotion in unilateral 6-hydroxydopamine lesioned rats. Brain Res 983 : 174-184, 2003   DOI
6 Wise RA : Dopamine, learning and motivation. Nat Rev Neurosci 5 : 483-494, 2004
7 Belke TW, Wagner JP : The reinforcing property and the rewarding aftereffect of wheel running in rats : a combination of two paradigms. Behav Processes 68 : 165-172, 2005   DOI
8 Bove J, Perier C : Neurotoxin-based models of Parkinson's disease. Neuroscience 211 : 51-76, 2012   DOI
9 Carman LS, Gage FH, Shults CW : Partial lesion of the substantia nigra : relation between extent of lesion and rotational behavior. Brain Res 553 : 275-283, 1991   DOI
10 Cenci MA, Whishaw IQ, Schallert T : Animal models of neurological deficits : how relevant is the rat? Nat Rev Neurosci 3 : 574-579, 2002   DOI
11 Chang JY, Shi LH, Luo F, Zhang WM, Woodward DJ : Studies of the neural mechanisms of deep brain stimulation in rodent models of Parkinson's disease. Neurosci Biobehav Rev 32 : 352-366, 2008   DOI
12 da Conceicao FS, Ngo-Abdalla S, Houzel JC, Rehen SK : Murine model for Parkinson's disease : from 6-OH dopamine lesion to behavioral test. J Vis Exp (35) : 1376, 2010. http://dx.doi.org/10.3791/1376   DOI
13 Deumens R, Blokland A, Prickaerts J : Modeling Parkinson's disease in rats : an evaluation of 6-OHDA lesions of the nigrostriatal pathway. Exp Neurol 175 : 303-317, 2002   DOI
14 Ito C, Onodera K, Sakurai E, Sato M, Watanabe T : Effect of cocaine on the histaminergic neuron system in the rat brain. J Neurochem 69 : 875-878, 1997
15 Fornaguera J, Schwarting RK : Early behavioral changes after nigro-striatal system damage can serve as predictors of striatal dopamine depletion. Prog Neuropsychopharmacol Biol Psychiatry 23 : 1353-1368, 1999   DOI
16 Galvan A, Wichmann T : Pathophysiology of parkinsonism. Clin Neurophysiol 119 : 1459-1474, 2008   DOI
17 Inden M, Taira T, Kitamura Y, Yanagida T, Tsuchiya D, Takata K, et al. : PARK7 DJ-1 protects against degeneration of nigral dopaminergic neurons in Parkinson's disease rat model. Neurobiol Dis 24 : 144-158, 2006   DOI
18 Iversen SD, Iversen LL : Dopamine : 50 years in perspective. Trends Neurosci 30 : 188-193, 2007   DOI
19 Kordower JH, Olanow CW, Dodiya HB, Chu Y, Beach TG, Adler CH, et al. : Disease duration and the integrity of the nigrostriatal system in Parkinson's disease. Brain 136 (Pt 8) : 2419-2431, 2013   DOI
20 Lau YS, Fung YK : Pharmacological effects of 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP) on striatal dopamine receptor system. Brain Res 369 : 311-315, 1986   DOI
21 Leng A, Mura A, Hengerer B, Feldon J, Ferger B : Effects of blocking the dopamine biosynthesis and of neurotoxic dopamine depletion with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on voluntary wheel running in mice. Behav Brain Res 154 : 375-383, 2004   DOI
22 Liebetanz D, Baier PC, Paulus W, Meuer K, Bahr M, Weishaupt JH : A highly sensitive automated complex running wheel test to detect latent motor deficits in the mouse MPTP model of Parkinson's disease. Exp Neurol 205 : 207-213, 2007   DOI
23 Reglodi D, Lubics A, Tamas A, Szalontay L, Lengvari I : Pituitary adenylate cyclase activating polypeptide protects dopaminergic neurons and improves behavioral deficits in a rat model of Parkinson's disease. Behav Brain Res 151 : 303-312, 2004   DOI
24 Meijer JH, Robbers Y : Wheel running in the wild. Proc Biol Sci 281 : 20140210, 2014. http://dx.doi.org/10.1098/rspb.2014.0210   DOI
25 Niu C, Mei J, Pan Q, Fu X : Nigral degeneration with inclusion body formation and behavioral changes in rats after proteasomal inhibition. Stereotact Funct Neurosurg 87 : 69-81, 2009   DOI
26 Paxinos G, Watson C : The Rat Brain in Stereotaxic Coordinates, ed 6. New York : Academic Press, 2007
27 Rosenwasser AM, Clark JW, Fixaris MC, Belanger GV, Foster JA : Effects of repeated light-dark phase shifts on voluntary ethanol and water intake in male and female Fischer and Lewis rats. Alcohol 44 : 229-237, 2010   DOI
28 Rosenwasser AM, Fixaris MC : Chronobiology of alcohol : studies in C57BL/6J and DBA/2J inbred mice. Physiol Behav 110-111 : 140-147, 2013   DOI
29 Sherwin CM : Voluntary wheel running : a review and novel interpretation. Anim Behav 56 : 11-27, 1998   DOI
30 Simola N, Morelli M, Carta AR. The 6-hydroxydopamine model of Parkinson's disease. Neurotox Res 11 : 151-167, 2007   DOI
31 Ungerstedt U : Postsynaptic supersensitivity after 6-hydroxy-dopamine induced degeneration of the nigro-striatal dopamine system. Acta Physiol Scand Suppl 367 : 69-93, 1971
32 Weihmuller FB, Bruno JP, Neff NH, Hadjiconstantinou M : Dopamine receptor plasticity following MPTP-induced nigrostriatal lesions in the mouse. Eur J Pharmacol 180 : 369-372, 1990   DOI