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http://dx.doi.org/10.3340/jkns.2015.57.2.77

Change in Plasma Vascular Endothelial Growth Factor after Gamma Knife Radiosurgery for Meningioma : A Preliminary Study  

Park, Seong-Hyun (Department of Neurosurgery, Kyungpook National University Hospital)
Hwang, Jeong-Hyun (Department of Neurosurgery, Kyungpook National University Hospital)
Hwang, Sung-Kyoo (Department of Neurosurgery, Kyungpook National University Hospital)
Publication Information
Journal of Korean Neurosurgical Society / v.57, no.2, 2015 , pp. 77-81 More about this Journal
Abstract
Objective : The purpose of this study was to investigate changes in the plasma level of vascular endothelial growth factor (VEGF) after Gamma Knife radiosurgery (GKRS) for the treatment of meningioma. Methods : Fourteen patients with meningiomas had peripheral venous blood collected at the time of GKRS and at 1 week, 1 month, 3 month and 6 month visits. Plasma VEGF levels were measured using commercially available enzyme-linked immunosorbent assay. For controls, peripheral blood samples were obtained from 20 healthy volunteers. Results : The mean plasma VEGF level (29.6 pg/mL) in patients with meningiomas before GKRS was significantly lower than that of the control group (62.4 pg/mL, p=0.019). At 1 week after GKRS, the mean plasma VEGF levels decreased to 23.4 pg/mL, and dropped to 13.9 pg/mL at 1 month, 14.8 pg/mL at 3 months, then increased to 27.7 pg/mL at 6 months. Two patients (14.3%) with peritumoral edema (PTE) showed a level of VEGF 6 months after GKRS higher than their preradiosurgical level. There was no significant association found in an analysis of correlation between PTE and tumor size, marginal dose, age, and sex. Conclusion : Our study is first in demonstrating changes of plasma VEGF after stereotactic radiosurgery (SRS) for meningioma. This study may provide a stimulus for more work related to whether measurement of plasma level has a correlation with tumor response after SRS for meningioma.
Keywords
Gamma Knife radiosurgery; Meningioma; Stereotactic radiosurgery; Vascular endothelial growth factor;
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