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http://dx.doi.org/10.3340/jkns.2014.55.1.40

Two Cystic Cavernous Angiomas after Radiotherapy for Atypical Meningioma in Adult Woman : Case Report and Literature Review  

Ruggeri, Andrea Gennaro (Department of Neurological Sciences-Neurosurgery, Sapienza University of Rome)
Donnarumma, Pasquale (Department of Neurological Sciences-Neurosurgery, Sapienza University of Rome)
Pichierri, Angelo (Department of Neurological Sciences-Neurosurgery, Sapienza University of Rome)
Delfini, Roberto (Department of Neurological Sciences-Neurosurgery, Sapienza University of Rome)
Publication Information
Journal of Korean Neurosurgical Society / v.55, no.1, 2014 , pp. 40-42 More about this Journal
Abstract
A correlation between radiation therapy and cavernoma has been suspected since 1994. Since then, only a few cases of radio-induced cavernomas have been reported in the literature (85 patients). Most of them were children, and the most frequent original tumour had been medulloblastoma. The authors report a case of two cystic cavernous angiomas after radiation therapy for atypical meningioma in adult woman. This is the first case of cavernous angioma after radiotherapy for low grade meningioma. A 39-year-old, Latin american woman was operated on for a frontal atypical meningioma with intradiploic component and adjuvant radiotherapy was delivered (6000 cGy local brain irradiation, fractionated over 6 weeks). Follow-up MR imaging showed no recurrences of the tumour and no other lesions. Ten years later, at the age of 49, she consulted for progressive drug-resistant headache. MR imaging revealed two new well defined areas of different signal intensity at the surface of each frontal pole. Both lesions were surgically removed; the histopathological diagnosis was cavernous angioma. This is the first case of cavernous angioma after radiation therapy for atypical meningioma : it confirms the development of these lesions after standard radiation therapy also in patients previously affected by non-malignant tumours.
Keywords
Cavernoma; Cavernous angioma; Cavernoma post-radiotherapy; Radiation therapy; Cystic cavernoma;
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