Browse > Article
http://dx.doi.org/10.3340/jkns.2013.54.6.528

Successful Treatment of Infantile Fibrosarcoma Spinal Metastasis by Chemotherapy and Stereotactic Hypofractionated Radiotherapy  

Lo, Cheng-Hsiang (Department of Radiation Oncology, Tri-Service General Hospital, National Defense Medical Center)
Cheng, Shin-Nan (Department of Pediatrics, Tri-Service General Hospital, National Defense Medical Center)
Lin, Kuen-Tze (Department of Radiation Oncology, Tri-Service General Hospital, National Defense Medical Center)
Jen, Yee-Min (Department of Radiation Oncology, Tri-Service General Hospital, National Defense Medical Center)
Publication Information
Journal of Korean Neurosurgical Society / v.54, no.6, 2013 , pp. 528-531 More about this Journal
Abstract
We report a case of infantile fibrosarcoma in an 8-month-old boy manifested as a right-sided lower leg mass. Repeated local recurrence and distant metastasis were noted during the following three-year period. Whole body fluoro-deoxyglucose positron emission tomography scan revealed an asymptomatic metastasis involving the fourth lumbar vertebrae. The patient received chemotherapy (VAC regimen) with Cyberknife$^{(R)}$ stereotactic hypofractionated radiotherapy (26 Gy; 4 fractions). This treatment reduced tumor size by 23% without acute radiation toxicity even after 33 months. This case suggests that combining chemotherapy and this form of radiotherapy may be safe and effective against childhood spinal metastasis.
Keywords
Cyberknife$^{(R)}$; Hypofractionated radiotherapy; Infantile fibrosarcoma; Spinal metastasis;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Giller CA, Berger BD, Gilio JP, Delp JL, Gall KP, Weprin B, et al. : Feasibility of radiosurgery for malignant brain tumors in infants by use of image-guided robotic radiosurgery : preliminary report. Neurosurgery 55 : 916-924; discussion 924-925, 2004   DOI
2 Giller CA, Berger BD, Pistenmaa DA, Sklar F, Weprin B, Shapiro K, et al. : Robotically guided radiosurgery for children. Pediatr Blood Cancer 45 : 304-310, 2005   DOI   ScienceOn
3 Hall EJ, Brenner DJ : The radiobiology of radiosurgery : rationale for different treatment regimes for AVMs and malignancies. Int J Radiat Oncol Biol Phys 25 : 381-385, 1993   DOI   ScienceOn
4 Hall WA, Stapleford LJ, Hadjipanayis CG, Curran WJ, Crocker I, Shu HK : Stereotactic body radiosurgery for spinal metastatic disease : an evidence-based review. Int J Surg Oncol 2011 : 979214, 2011
5 Kerl K, Nowacki M, Leuschner I, Masjosthusmann K, Frühwald MC : Infantile fibrosarcoma - an important differential diagnosis of congenital vascular tumors. Pediatr Hematol Oncol 29 : 545-548, 2012   DOI   ScienceOn
6 Orbach D, Rey A, Cecchetto G, Oberlin O, Casanova M, Thebaud E, et al. : Infantile fibrosarcoma : management based on the European experience. J Clin Oncol 28 : 318-323, 2010   DOI   ScienceOn
7 Peugniez C, Dewas S, Coche-Dequeant B, Leblond P, Defachelles AS, Thebaud E, et al. : Use of conventional fractionation with cyberknife in children : a report of 5 cases. J Pediatr Hematol Oncol 32 : 472-475, 2010   DOI   ScienceOn
8 Ramuz O, Bourhis J, Mornex F : [Late effects of radiations on mature and growing bone]. Cancer Radiother 1 : 801-809, 1997   DOI   ScienceOn
9 Shah NN, Price MR, Loeb DM : Cardiac metastasis and hypertrophic osteoarthropathy in recurrent infantile fibrosarcoma. Pediatr Blood Cancer 59 : 179-181, 2012   DOI   ScienceOn
10 Sinha AK, Seki JT, Moreau G, Ventureyra E, Letts RM : The management of spinal metastasis in children. Can J Surg 40 : 218-226, 1997
11 Wara WM, Phillips TL, Sheline GE, Schwade JG : Radiation tolerance of the spinal cord. Cancer 35 : 1558-1562, 1975   DOI
12 Garg AK, Wang XS, Shiu AS, Allen P, Yang J, McAleer MF, et al. : Prospective evaluation of spinal reirradiation by using stereotactic body radiation therapy : The University of Texas MD Anderson Cancer Center experience. Cancer 117 : 3509-3516, 2011   DOI   ScienceOn
13 Chang UK, Youn SM, Park SQ, Rhee CH : Clinical results of cyberknife(r) radiosurgery for spinal metastases. J Korean Neurosurg Soc 46 : 538-544, 2009   DOI
14 Diallo I, Haddy N, Adjadj E, Samand A, Quiniou E, Chavaudra J, et al. : Frequency distribution of second solid cancer locations in relation to the irradiated volume among 115 patients treated for childhood cancer. Int J Radiat Oncol Biol Phys 74 : 876-883, 2009   DOI   ScienceOn
15 Fletcher CDM, Unni K, Mertens K : World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone. Lyon : IARC Press, 2002, pp98-101
16 Gerszten PC, Burton SA, Ozhasoglu C, Welch WC : Radiosurgery for spinal metastases : clinical experience in 500 cases from a single institution. Spine (Phila Pa 1976) 32 : 193-199, 2007   DOI   ScienceOn
17 Gibbs IC, Patil C, Gerszten PC, Adler JR Jr, Burton SA : Delayed radiation-induced myelopathy after spinal radiosurgery. Neurosurgery 64 (2 Suppl) : A67-A72, 2009   DOI   ScienceOn