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http://dx.doi.org/10.3340/jkns.2013.54.6.521

Multiple Spinal Cord Recurrences of an Intracranial Ependymoma after 14 Years  

Hong, Semie (Department of Radiation Oncology, Konkuk University School of Medicine)
Choe, Woo Jin (Department of Neurosurgery, Konkuk University School of Medicine)
Moon, Chang Taek (Department of Neurosurgery, Konkuk University School of Medicine)
Publication Information
Journal of Korean Neurosurgical Society / v.54, no.6, 2013 , pp. 521-524 More about this Journal
Abstract
Ependymoma can spread via cerebrospinal fluid, but late spinal recurrences of intracranial tumor are very rare. We describe a case of a 33-year-old male who presented with multiple, delayed, recurrent lesions in the spinal cord from an intracranial ependymoma. The patient underwent gross total resection and postoperative radiation therapy 14 years prior to visit for a low grade ependymoma in the 4th ventricle. The large thoraco-lumbar intradural-extramedullary spinal cord tumor was surgically removed and the pathologic diagnosis was an anaplastic ependymoma. An adjuvant whole-spine radiation therapy for residual spine lesions was performed. After completion of radiation therapy, a MRI showed a near complete response and the disease was stable for three years.
Keywords
Fourth ventricle ependymoma; Delayed spinal recurrence; Anaplastic transformation;
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1 Vanuytsel L, Brada M : The role of prophylactic spinal irradiation in localized intracranial ependymoma. Int J Radiat Oncol Biol Phys 21 : 825-830, 1991   DOI   ScienceOn
2 Whitaker SJ, Bessell EM, Ashley SE, Bloom HJ, Bell BA, Brada M : Postoperative radiotherapy in the management of spinal cord ependymoma. J Neurosurg 74 : 720-728, 1991   DOI
3 Halvorsen CM, Kolstad F, Hald J, Johannesen TB, Krossnes BK, Langmoen IA, et al. : Long-term outcome after resection of intraspinal ependymomas : report of 86 consecutive cases. Neurosurgery 67 : 1622-1631; discussion 1631, 2010   DOI   ScienceOn
4 Iunes EA, Stavale JN, de Cassia Caldas Pessoa R, Ansai R, Onishi FJ, de Paiva Neto MA, et al. : Multifocal intradural extramedullary ependymoma. Case report. J Neurosurg Spine 14 : 65-70, 2011   DOI   ScienceOn
5 Kim DG, Cho BK, Yang HJ, Chi JG, Jung HW, Kim HJ, et al. : Intracranial Ependymoma : Clinicopathologic Features and Prognostic Factors.J Korean Neurosurg Soc 20 : 893-899, 1991
6 Kleihues P, Burger PC, Scheithauer BW, Zulch KJ : Histological typing of tumours of the central nervous system, ed 2. Berlin : Springer-Verlag, 1993
7 McLaughlin MP, Marcus RB Jr, Buatti JM, McCollough WM, Mickle JP, Kedar A, et al. : Ependymoma: results, prognostic factors and treatment recommendations. Int J Radiat Oncol Biol Phys 40 : 845-850, 1998   DOI   ScienceOn
8 Metellus P, Guyotat J, Chinot O, Durand A, Barrie M, Giorgi R, et al. : Adult intracranial WHO grade II ependymomas : long-term outcome and prognostic factor analysis in a series of 114 patients. Neuro Oncol 12 : 976-984, 2010   DOI   ScienceOn
9 Nakasu S, Ohashi M, Suzuki F, Matsuda M : Late dissemination of fourth ventricle ependymoma : a case report. J Neurooncol 55 : 117-120, 2001   DOI   ScienceOn
10 Ochiai H, Yamakawa Y, Kawano H, Shimao Y, Hayashi T : Late spinal cord metastasis of fourth ventricle ependymoma appeared nineteen years after the initial treatment. J Neurooncol 96 : 295-299, 2010   DOI
11 Bademci G, Tun K, Erden E, Evliyaoglu C, Unlu A : Late dissemination of ependymoma : case report. Neurocirugia (Astur) 18 : 333-336, 2007   DOI
12 Rehman S, Brock C, Newlands ES : A case report of a recurrent intracranial ependymoma treated with temozolomide in remission 10 years after completing chemotherapy. Am J Clin Oncol 29 : 106-107, 2006   DOI   ScienceOn
13 Rezai AR, Woo HH, Lee M, Cohen H, Zagzag D, Epstein FJ : Disseminated ependymomas of the central nervous system. J Neurosurg 85 : 618-624, 1996   DOI   ScienceOn
14 Salazar OM, Castro-Vita H, VanHoutte P, Rubin P, Aygun C : Improved survival in cases of intracranial ependymoma after radiation therapy. Late report and recommendations. J Neurosurg 59 : 652-659, 1983   DOI
15 Ernestus RI, SchrOder R, Stützer H, Klug N : The clinical and prognostic relevance of grading in intracranial ependymomas. Br J Neurosurg 11 : 421-428, 1997   DOI
16 Bortolotto S, Chiado-Piat L, Cavalla P, Bosone I, Mauro A, Schiffer D : CDKN2A/p16 in ependymomas. J Neurooncol 54 : 9-13, 2001   DOI   ScienceOn
17 Celli P, Cervoni L, Salvati M, Cantore G : Recurrence from filum terminale ependymoma 42 years after 'total' removal and radiotherapy. J Neurooncol 34 : 153-156, 1997   DOI   ScienceOn
18 Chao ST, Kobayashi T, Benzel E, Reddy CA, Stevens GH, Prayson RA, et al. : The role of adjuvant radiation therapy in the treatment of spinal myxopapillary ependymomas. J Neurosurg Spine 14 : 59-64, 2011   DOI   ScienceOn
19 Good CD, Wade AM, Hayward RD, Phipps KP, Michalski AJ, Harkness WF, et al. : Surveillance neuroimaging in childhood intracranial ependymoma : how effective, how often, and for how long? J Neurosurg 94 : 27-32, 2001   DOI   ScienceOn
20 Lyons MK, Kelly PJ : Posterior fossa ependymomas : report of 30 cases and review of the literature. Neurosurgery 28 : 659-664; discussion 664-665, 1991   DOI