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http://dx.doi.org/10.3340/jkns.2012.52.3.250

Cerebellar Liponeurocytoma with an Unusually Aggressive Histopathology : Case Report and Review of the Literature  

Chung, Sang-Bong (Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine)
Suh, Yeon-Lim (Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine)
Lee, Jung-Il (Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine)
Publication Information
Journal of Korean Neurosurgical Society / v.52, no.3, 2012 , pp. 250-253 More about this Journal
Abstract
We report a rare case of cerebellar liponeurocytoma with an unusually aggressive histopathology. A 49-year-old man presented with a four-month history of headache, vertigo, and progressive swaying gait. Magnetic resonance imaging showed a $3{\times}3.5cm$ sized relatively well-demarcated round mass lesion in the fourth ventricle, characterized by high signal intensity on T2-weighted images. Postcontrast images revealed strong enhancement of the solid portion and the cyst wall. The patient underwent suboccipital craniectomy and tumor removal. The pathologic diagnosis was cerebellar liponeurocytoma. Adjuvant radiotherapy was offered due to concerns related to the high proliferative index (Ki-67, 13.68%) of the tumor. At the last routine postoperative follow-up visit (12 months), the patient complained of no specific symptom and there was no evidence of tumor recurrence. However, longterm follow-up and the analysis of similar cases are necessary because of the low number of reports and the short follow-up of cases.
Keywords
Liponeurocytoma; Ki-67 index; Radiotherapy;
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1 Buccoliero AM, Caldarella A, Bacci S, Gallina P, Taddei A, Di Lorenzo N, et al. : Cerebellar liponeurocytoma : morphological, immunohistochemical, and ultrastructural study of a relapsed case. Neuropathology 25 : 77-83, 2005   DOI   ScienceOn
2 Cacciola F, Conti R, Taddei GL, Buccoliero AM, Di Lorenzo N : Cerebellar liponeurocytoma. Case report with considerations on prognosis and management. Acta Neurochir (Wien) 144 : 829-833, 2002   DOI   ScienceOn
3 Châtillon CE, Guiot MC, Roberge D, Leblanc R : Cerebellar liponeurocytoma with high proliferation index : treatment options. Can J Neurol Sci 36 : 658-661, 2009   DOI
4 Davis DG, Wilson D, Schmitz M, Markesbery WR : Lipidized medulloblastoma in adults. Hum Pathol 24 : 990-995, 1993   DOI   ScienceOn
5 Giangaspero F, Cenacchi G, Roncaroli F, Rigobello L, Manetto V, Gambacorta M, et al. : Medullocytoma (lipidized medulloblastoma). A cerebellar neoplasm of adults with favorable prognosis. Am J Surg Pathol 20 : 656-664, 1996   DOI   ScienceOn
6 González-Cámpora R, Weller RO : Lipidized mature neuroectodermal tumour of the cerebellum with myoid differentiation. Neuropathol Appl Neurobiol 24 : 397-402, 1998   DOI   ScienceOn
7 Horstmann S, Perry A, Reifenberger G, Giangaspero F, Huang H, Hara A, et al. : Genetic and expression profiles of cerebellar liponeurocytomas. Brain Pathol 14 : 281-289, 2004
8 Jackson TR, Regine WF, Wilson D, Davis DG : Cerebellar liponeurocytoma. Case report and review of the literature. J Neurosurg 95 : 700- 703, 2001   DOI   ScienceOn
9 Jenkinson MD, Bosma JJ, Du Plessis D, Ohgaki H, Kleihues P, Warnke P, et al. : Cerebellar liponeurocytoma with an unusually aggressive clinicalcourse : case report. Neurosurgery 53 : 1425-1427; discussion 1428, 2003   DOI
10 Kleihues P, Louis DN, Scheithauer BW, Rorke LB, Reifenberger G, Burger PC, et al. : The WHO classification of tumors of the nervous system. J Neuropathol Exp Neurol 61 : 215-225; discussion 226-229, 2002   DOI
11 Orlandi A, Marino B, Brunori M, Greco R, Spagnoli LG : Lipomatousmedulloblastoma. Clin Neuropathol 16 : 175-179, 1997
12 Owler BK, Makeham JM, Shingde M, Besser M : Cerebellar liponeurocytoma. J Clin Neurosci 12 : 326-329, 2005   DOI   ScienceOn
13 Soylemezoglu F, Soffer D, Onol B, Schwechheimer K, Kleihues P : Lipomatous medulloblastoma in adults. A distinct clinicopathological entity. Am J Surg Pathol 20 : 413-418, 1996   DOI   ScienceOn
14 Aker FV, Ozkara S, Eren P, Peker O, Armagan S, Hakan T : Cerebellar liponeurocytoma/lipidized medulloblastoma. J Neurooncol 71 : 53-59, 2005   DOI   ScienceOn
15 Alkadhi H, Keller M, Brandner S, Yonekawa Y, Kollias SS : Neuroimaging of cerebellar liponeurocytoma. Case report. J Neurosurg 95 : 324- 331, 2001   DOI   ScienceOn
16 Bechtel JT, Patton JM, Takei Y : Mixed mesenchymal and neuroectodermal tumor of the cerebellum. Acta Neuropathol 41 : 261-263, 1978   DOI   ScienceOn