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http://dx.doi.org/10.3340/jkns.2012.51.4.199

The Role of Chemotherapy in Anaplastic Astrocytoma Patients  

Kim, Sung-Kwon (Department of Neurosurgery, Seoul National University College of Medicine)
Kim, Jin-Wook (Department of Neurosurgery, Seoul National University College of Medicine)
Kim, Yong-Hwy (Department of Neurosurgery, Seoul National University College of Medicine)
Kim, Tae-Min (Department of Internal Medicine, Seoul National University College of Medicine)
Lee, Se-Hoon (Department of Internal Medicine, Seoul National University College of Medicine)
Park, Chul-Kee (Department of Neurosurgery, Seoul National University College of Medicine)
Publication Information
Journal of Korean Neurosurgical Society / v.51, no.4, 2012 , pp. 199-202 More about this Journal
Abstract
Objective: This retrospective study was performed to evaluate the role of chemotherapy in the management of patients with anaplastic astrocytoma (AA). Methods: We compared the survival outcome among the 3 different treatment protocol groups in a single institution. A total of 86 patients (39 men and 47 women) with newly diagnosed AA after surgery were analyzed. Among them, 31 patients (36.0%) were treated with radiotherapy only (RT Group), 30 patients (34.9%) were treated with nimustine-cisplatin chemotherapy before RT (ACNU-COOP group), and 25 patients (29.1 %) were treated with procarbazine, lomustine and vincristine (PCV) chemotherapy after radiotherapy (PCV group). Results: The median survival was 14.0, 30.0 and 72.0 months in RT, ACNU-COOP, and PCV group, respectively and showed significant differences (RT vs. ACNU-COOP; p=0.039, RT vs. PCV; 0.002, ACNU-COOP vs. PCV; 0.045). PCV group showed less toxicity rate (5 patients; 20%) than ACNU-COOP group (12 patients; 40%), while only 3 patients (9.6%) in RT group experienced grade 3 or 4 toxicities. Conclusion: An application of chemotherapy before or after radiotherapy is beneficial in prolonging the survival of patients with AA. Adjuvant PCV chemotherapy after radiotherapy is recommendable.
Keywords
Anaplastic astrocytoma; Chemotherapy; Procarbazine; Lomustine; Vincristine; PCV; Nimustine-cisplatin;
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