Browse > Article
http://dx.doi.org/10.3340/jkns.2011.50.2.109

The Effect of Phosphodiesterase-4-Specific Inhibitor in the Rat Model of Spinal Nerve Ligation  

Kim, Sung-Hoon (Department of Rehabilitation, College of Medicine, Wonju Christian Hospital, Yonsei University)
Park, Bit-Na-Ri (Department of Rehabilitation, College of Medicine, Wonju Christian Hospital, Yonsei University)
Kim, Seok-Won (Department of Neurosurgery, College of Medicine, Chosun University)
Publication Information
Journal of Korean Neurosurgical Society / v.50, no.2, 2011 , pp. 109-113 More about this Journal
Abstract
Objective : Peripheral neuropathy is characterized by hyperalgesia, spontaneous burning pain, and allodynia. The purpose of this study was to investigate the effect of rolipram, a phosphodiesterase-4-specific inhibitor, in a segmental spinal nerve ligation model in rats. Methods : Both the L5 and L6 spinal nerves of the left side of the rats were ligated. Phosphodiesterase-4 inhibitor (rolipram) and saline (vehicle) were administered intraperitoneally. We measured mechanical allodynia using von Frey filaments and a nerve conduction study. Results : The mechanical allodynia, which began to manifest on the first day, peaked within 2 days. Multiple intraperitoneal injections of rolipram ameliorated the mechanical allodynia. Furthermore, an intraperitoneal administration of rolipram improved the development of pain behavior and nerve conduction velocity. Conclusion : This study suggests that the phosphodiesterase-4 inhibitor, rolipram, alleviates mechanical allodynia induced by segmental spinal nerve ligation in rats. This finding may have clinical implications.
Keywords
Peripheral nerve injury; Allodynia; Rolipram;
Citations & Related Records

Times Cited By Web Of Science : 0  (Related Records In Web of Science)
Times Cited By SCOPUS : 0
연도 인용수 순위
  • Reference
1 Padi SS, Kulkarni SK : Minocycline prevents the development of neuropathic pain, but not acute pain : Possible anti-inflammatory and antioxidant mechanisms. Eur J Pharmacol 601 : 79-87, 2008   DOI
2 Pearse DD, Pereira FC, Marcillo AE, Bates ML, Berrocal YA, Filbin MT, et al. : Camp and schwann cells promoted axonal growth and functional recovery after spinal cord injury. Nat Med 10 : 610-616, 2004   DOI   ScienceOn
3 Pentney RJ, Quackenbush LJ : Dendritic hypertrophy in Purkinje neurons of old Fischer 344 rats after long-term ethanol treatment. Alcohol Clin Exp Res 14 : 878-886, 1990   DOI   ScienceOn
4 Schaal SM GM, Golshani R, Ghosh M, Lovera L, Lopez M, Patel M, et al. : Targeting phosphodiesterase-4 after spinal cord injury using pharmacological and molecular approches. J Neurotrauma 25 : 297, 2008
5 Sharma SS, Sayyed SG : Effects of trolox on nerve dysfunction, thermal hyperalgesia and oxidative stress in experimental diabetic neuropathy Clin Exp Pharmacol Physiol 33 : 1022-1028, 2006   DOI   ScienceOn
6 Soares HD, Hicks RR, Smith D, McIntosh TK : Inflammatory leukocytic recruitment and diffuse neuronal degeneration are separate pathological processes resulting from traumatic brain injury. J Neurosci 15 : 8223-8233, 1995
7 Tanaka M, Sotomatsu A, Yoshida T, Hirai S, Nishida A : Detection of superoxide production by activated microglia using a sensitive and specific chemiluminescence assay and microglia-mediated PC12h cell death. J Neurochem 63 : 266-270, 1994
8 Floyd RA, Hensley K : Oxidative stress in brain aging. Implications for therapeutics of neurodegenerative diseases. Neurobiol Aging 23 : 795-807, 2002   DOI   ScienceOn
9 Gomberg ES : Women and alcohol : use and abuse. J Nerv Ment Dis 181 : 211-219, 1993   DOI   ScienceOn
10 Hou S, Guan H, Ricciardi RP : Phosphorylation of serine 337 of NF-kappaB p50 is critical for DNA binding. J Biol Chem 278 : 45994-45998, 2003   DOI
11 Hu S, Peterson PK, Chao CC : Cytokine-mediated neuronal apoptosis.Neurochem Int 30 : 427-431, 1997   DOI   ScienceOn
12 Keeling KL, Hicks RR, Mahesh J, Billings BB, Kotwal GJ : Local neutrophil influx following lateral fluid-percussion brain injury in rats is associated with accumulation of complement activation fragments of the third component (C3) of the complement system. J Neuroimmunol 105 : 20-30, 2000   DOI   ScienceOn
13 Kinoshita K, Chatzipanteli K, Vitarbo E, Truettner JS, Alonso OF, Dietrich WD : Interleukin-1beta messenger ribonucleic acid and protein levels after fluid-percussion brain injury in rats : importance of injury severity and brain temperature. Neurosurgery 51 : 195-203; discussion 203, 2002   DOI   ScienceOn
14 Koike H, Iijima M, Sugiura M, Mori K, Hattori N, Ito H, et al. : Alcoholic neuropathy is clinicopathologically distinct from thiamine-deficiency neuropathy. Ann Neurol 54 : 19-29, 2003   DOI   ScienceOn
15 Lander HM : An essential role for free radicals and derived species in signal transduction. FASEB J 11 : 118-124, 1997   DOI
16 Lee I, Kim HK, Kim JH, Chung K, Chung JM : The role of reactive oxygen species in capsaicin-induced mechanical hyperalgesia and in the activities of dorsal horn neurons. Pain 133 : 9-17, 2007   DOI   ScienceOn
17 Manganiello VC, Murata T, Taira M, Belfrage P, Degerman E : Diversity in cyclic nucleotide phosphodiesterase isoenzyme families. Arch Biochem Biophys 322 : 1-13, 1995   DOI   ScienceOn
18 Mayr B, Montminy M : Transcriptional regulation by the phosphorylation-dependent factor CREB. Nat Rev Mol Cell Biol 2 : 599-609, 2001   DOI   ScienceOn
19 Meda L, Cassatella MA, Szendrei GI, Otvos L Jr, Baron P, Villalba M, et al. : Activation of microglial cells by beta-amyloid protein and interferon-gamma. Nature 374 : 647-650, 1995   DOI   ScienceOn
20 Atkins CM, Oliva AA Jr, Alonso OF, Pearse DD, Bramlett HM, Dietrich WD : Modulation of the cAMP signaling pathway after traumatic brain injury. Exp Neurol 208 : 145-158, 2007   DOI   ScienceOn
21 Bosch EP, Pelham RW, Rasool CG, Chatterjee A, Lash RW, Brown L, et al. : Animal models of alcoholic neuropathy : morphologic, electrophysiologic, and biochemical findings. Muscle Nerve 2 : 133-144, 1979   DOI   ScienceOn
22 Brain WR WJ : Disorders of peripheral nerves : Alcoholoc polyneuritis. In : Brain's deseases of the nervous system. London, 1969, pp817-819
23 Cogswell JP, Godlevski MM, Wisely GB, Clay WC, Leesnitzer LM, Ways JP, et al. : NF-kappa B regulates IL-1 beta transcription through a consensus NF-kappa B binding site and a nonconsensus CRE-like site. J Immunol 153 : 712-723, 1994
24 Corsetti G, Rezzani R, Rodella L, Bianchi R : Ultrastructural study of the alterations in spinal ganglion cells of rats chronically fed on ethanol. Ultrastruct Pathol 22 : 309-319, 1998   DOI   ScienceOn
25 Dina OA, Barletta J, Chen X, Mutero A, Martin A, Messing RO, et al. : Key role for the epsilon isoform of protein kinase C in painful alcoholic neuropathy in the rat. J Neurosci 20 : 8614-8619, 2000
26 Dixon WJ : Efficient analysis of experimental observations. Annu Rev Pharmacol Toxicol 20 : 441-462, 1980   DOI   ScienceOn
27 Fillmore KM : Women's drinking across the adult life course as compared to men's. Br J Addict 82 : 801-811, 1987   DOI
28 Floyd RA : Antioxidants, oxidative stress, and degenerative neurological disorders. Proc Soc Exp Biol Med 222 : 236-245, 1999   DOI   ScienceOn
29 Victor M : Polyneuropathy due to nutritional deficiency and alcoholism. Philadelphia : WB Saunder's Co., 1975
30 Verghese MW, McConnell RT, Strickland AB, Gooding RC, Stimpson SA, Yarnall DP, et al. : Differential regulation of human monocyte-derived TNF alpha and IL-1 beta by type IV cAMP-phosphodiesterase (cAMP-PDE) inhibitors. J Pharmacol Exp Ther 272 : 1313-1320, 1995
31 Vitarbo EA, Chatzipanteli K, Kinoshita K, Truettner JS, Alonso OF, Dietrich WD : Tumor necrosis factor alpha expression and protein levels after fluid percussion injury in rats : the effect of injury severity and brain temperature. Neurosurgery 55 : 416-424; discussion 424-425, 2004   DOI   ScienceOn
32 Yerdelen D, Koc F, Uysal H : Strength-duration properties of sensory and motor axons in alcoholic polyneuropathy. Neurol Res 30 : 746-750, 2008   DOI   ScienceOn
33 Zou J, Rabin RA, Pentney RJ : Ethanol enhances neurite outgrowth in primary cultures of rat cerebellar macroneurons. Brain Res Dev Brain Res 72 : 75-84,1993   DOI   ScienceOn
34 Nikulina E, Tidwell JL, Dai HN, Bregman BS, Filbin MT : The phosphodiesterase inhibitor rolipram delivered after a spinal cord lesion promotes axonal regeneration and functional recovery. Proc Natl Acad Sci U S A 101 : 8786-8790, 2004   DOI   ScienceOn
35 Monforte R, Estruch R, Valls-Solé J, Nicolás J, Villalta J, Urbano-Marquez A : Autonomic and peripheral neuropathies in patients with chronic alcoholism. A dose-related toxic effect of alcohol. Arch Neurol 52 : 45-51, 1995   DOI   ScienceOn
36 Naik AK, Tandan SK, Dudhgaonkar SP, Jadhav SH, Kataria M, Prakash VR, et al. : Role of oxidative stress in pathophysiology of peripheral neuropathy and modulation by N-acetyl-L-cysteine in rats. Eur J Pain 10 : 573-579, 2006   DOI   ScienceOn
37 Narita M, Miyoshi K, Suzuki T : Involvement of microglia in the ethanol-induced neuropathic pain-like state in the rat. Neurosci Lett 414 : 21-25, 2007   DOI   ScienceOn