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http://dx.doi.org/10.3340/jkns.2011.49.6.323

Effect of Amniotic Membrane to Reduce Postlaminectomy Epidural Adhesion on a Rat Model  

Choi, Hyu-Jin (Department of Neurosurgery, College of Medicine, Dong-A University)
Kim, Kyoung-Beom (Department of Neurosurgery, The Grand Spine Hospital)
Kwon, Young-Min (Department of Neurosurgery, College of Medicine, Dong-A University)
Publication Information
Journal of Korean Neurosurgical Society / v.49, no.6, 2011 , pp. 323-328 More about this Journal
Abstract
Objective : Epidural fibrosis and adhesion are the main reasons for post-laminectomy sustained pain and functional disability. In this study, the authors investigate the effect of irradiated freeze-dried human amniotic membrane on reducing epidural adhesion after laminectomy on a rat model. Methods : A total of 20 rats were divided into two groups. The group A did not receive human amniotic membrane implantation after laminectomy and group B underwent human amniotic membrane implantation after laminectomy. Gross and microscopic findings were evaluated and compared at postoperative 1, 3 and 8 weeks. Results : The amount of scar tissue and tenacity were reduced grossly in group of rats with human amniotic membrane implantation (group B). On a microscopic evaluation, there were less inflammatory cell infiltration and fibroblast proliferation in group B. Conclusion : This experimental study shows that implantation of irradiated freeze-dried human amniotic membrane reduce epidural fibrosis and adhesion after spinal laminectomy in a rat model.
Keywords
Human amniotic membrane; Failed back surgery syndrome; Epidural adhesion; Laminectomy;
Citations & Related Records
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Times Cited By Web Of Science : 0  (Related Records In Web of Science)
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