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http://dx.doi.org/10.3340/jkns.2010.48.1.8

Comparative Analysis of Serum Proteomes of Moyamoya Disease and Normal Controls  

Koh, Eun-Jeong (Department of Neurosurgery, Chonbuk National University Medical School)
Kim, Han-Na (Department of Pharmacology, Chonbuk National University Medical School)
Ma, Tian-Ze (Department of Pharmacology, Chonbuk National University Medical School)
Choi, Ha-Young (Department of Neurosurgery, Chonbuk National University Medical School)
Kwak, Yong-Geun (Department of Pharmacology, Chonbuk National University Medical School)
Publication Information
Journal of Korean Neurosurgical Society / v.48, no.1, 2010 , pp. 8-13 More about this Journal
Abstract
Objective : The etiology and pathogenesis of moyamoya disease remain unclear. Furthermore, the definitive diagnostic protein-biomarkers for moyamoya disease are still unknown. The present study analyzed serum proteomes from normal controls and moyamoya patients to identify novel serological biomarkers for diagnosing moyamoya disease. Methods : We compared the two-dimensional electrophoresis patterns of sera from moyamoya disease patients and normal controls and identified the differentially-expressed spots by matrix-assisted laser desorption/ionization-time-of flight mass spectrometry and electrospray ionization quadruple time-of-flight mass spectrometry. Results : We found and analyzed 22 differently-expressed proteomes. Two proteins were up-regulated. Twenty proteins were down-regulated. Complement C1 inhibitor protein and apolipoprotein C-III showed predominantly changed expressions (complement C1 inhibitor protein averaged a 7.23-fold expression in moyamoya patients as compared to controls, while apolipoprotein C-III averaged a 0.066-fold expression). Conclusion : Although our study had a small sample size, our proteomic data provide serologic clue proteins for understanding moyamoya disease.
Keywords
Moyamoya disease; Proteome;
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