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http://dx.doi.org/10.3340/jkns.2010.48.1.14

Loss of Heterozygosity at 1p, 7q, 17p, and 22q in Meningiomas  

Chang, In-Sok (Department of Neurosurgery, Hallym University College of Medicine)
Cho, Byung-Moon (Department of Neurosurgery, Hallym University College of Medicine)
Moon, Seung-Myung (Department of Neurosurgery, Hallym University College of Medicine)
Park, Se-Hyuck (Department of Neurosurgery, Hallym University College of Medicine)
Oh, Sae-Moon (Department of Neurosurgery, Hallym University College of Medicine)
Cho, Seong-Jjn (Department of Pathology, Hallym University College of Medicine)
Publication Information
Journal of Korean Neurosurgical Society / v.48, no.1, 2010 , pp. 14-19 More about this Journal
Abstract
Objective : Allelic losses or loss of heterozygosity (LOH) at many chromosomal loci have been found in the cells of meningiomas. The objective of this study was to evaluate LOH at several loci of different chromosomes (1p32, 17p13, 7q21, 7q31, and 22q13) in different grades of meningiomas. Methods : Forty surgical specimens were obtained and classified as benign, atypical, and anaplastic meningiomas. After DNA extraction, ten polymorphic microsatellite markers were used to detect LOH. Medical and surgical records, as well as pathologic findings, were reviewed retrospectively. Results : LOH at 1p32 was detected in 24%, 60%, and 60% in benign, atypical, and anaplastic meningiomas, respectively. Whereas LOH at 7q21 was found in only one atypical meningioma. LOH at 7q31 was found in one benign meningioma and one atypical meningioma. LOH at 17p13 was detected in 4%, 40%, and 80% in benign, atypical, and anaplastic meningiomas, respectively. LOH at 22q13 was seen in 48%, 60%, and 60% in benign, atypical, and anaplastic meningiomas, respectively. LOH results at 1p32 and 17p13 showed statistically significant differences between benign and non-benign meningiomas. Conclusion : LOH at 1p32 and 17p13 showed a strong correlation with tumor progression. On the other hand, LOH at 7q21 and 7q31 may not contribute to the development of the meningiomas.
Keywords
Chromosome; Loss of heterozygosity; Meningiomas;
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1 Martinez-Rumayor A, Arrieta O, Guevara P, Escobar E, Rembao D, Salina C, et al. : Coexpression of hepatocyte growth factor/scatter factor (HGF/SF) and its receptor cMET predict recurrence of meningiomas. Cancer Lett 213 : 117-124, 2004   DOI   ScienceOn
2 Riemenschneider MJ, Perry A, Reifenberger G : Histological classification and molecular genetics of meningiomas. Lancet Neurol 5 : 1045-1054, 2006   DOI   ScienceOn
3 Kim JH, Lee SH, Rhee CH, Park SY, Lee JH : Loss of heterozygosity on chromosome 22q and 17p correlates with aggressiveness of meningiomas. J Neurooncol 40 : 101-106, 1998   DOI   ScienceOn
4 Weber RG, Bostrom J, Wolter M, Baudis M, Collins VP, Reifenberger G, et al. : Analysis of genomic alterations in benign, atypical, and anaplastic meningiomas : toward a genetic model of meningioma progression. Proc Natl Acad Sci U S A 94 : 14719-14724, 1997   DOI   ScienceOn
5 Simon M, von Deimling A, Larson JJ, Wellenreuther R, Kaskel P, Waha A, et al. : Allelic losses on chromosomes 14, 10, and 1 in atypical and malignant meningiomas : a genetic model of meningioma progression. Cancer Res 55 : 4696-4701, 1995
6 Sulman EP, Dumanski JP, White PS, Zhao H, Maris JM, Mathiesen T, et al. : Identification of a consistent region of allelic loss on 1p32 in meningiomas : correlation with increased morbidity. Cancer Res 58 : 3226-3230, 1998
7 Ueki K, Wen-Bin C, Narita Y, Asai A, Kirino T : Tight association of loss of merlin expression with loss of heterozygosity at chromosome 22q in sporadic meningiomas. Cancer Res 59 : 5995-5998, 1999
8 Zhou CZ, Qiu GQ, Zhang F, He L, Peng ZH : Loss of heterozygosity on chromosome 1 in sporadic colorectal carcinoma. World J Gastroenterol 10 : 1431-1435, 2004
9 Weissenbach J, Gyapay G, Dib C, Vignal A, Morissette J, Millasseau P, et al. : A second-generation linkage map of the human genome. Nature 359 : 794-801, 1992   DOI   ScienceOn
10 Zankl H, Zang KD : Cytological and cytogenetical studies on brain tumors. 4. Identification of the missing G chromosome in human meningiomas as no. 22 by fluorescence technique. Humangenetik 14 : 167-169, 1972   DOI
11 Maulik G, Shrikhande A, Kijima T, Ma PC, Morrison PT, Salgia R : Role of the hepatocyte growth factor receptor, c-Met, in oncogenesis and potential for therapeutic inhibition. Cytokine Growth Factor Rev 13 : 41-59, 2002   DOI   ScienceOn
12 Moriyama T, Kataoka H, Kawano H, Yokogami K, Nakano S, Goya T, et al. : Comparative analysis of expression of hepatocyte growth factor and its receptor, c-met, in gliomas, meningiomas and schwannomas in humans. Cancer Lett 124 : 149-155, 1998   DOI   ScienceOn
13 Niedermayer I, Feiden W, Henn W, Steilen-Gimbel H, Steudel WI, Zang KD : Loss of alkaline phosphatase activity in meningiomas : a rapid histochemical technique indicating progression-associated deletion of a putative tumor suppressor gene on the distal part of the short arm of chromosome 1. J Neuropathol Exp Neurol 56 : 879-886, 1997   DOI   ScienceOn
14 Nigro JM, Baker SJ, Preisinger AC, Jessup JM, Hostetter R, Cleary K, et al. : Mutations in the p53 gene occur in diverse human tumour types. Nature 342 : 705-708, 1989   DOI   ScienceOn
15 Pykett MJ, Landers J, George DL : Expression patterns of the p53 tumor suppressor gene and the mdm2 proto-oncogene in human meningiomas. J Neurooncol 32 : 39-44, 1997   DOI   ScienceOn
16 Ohgaki H, Eibl RH, Wiestler OD, Yasargil MG, Newcomb EW, Kleihues P : p53 mutations in nonastrocytic human brain tumors. Cancer Res 51 : 6202-6205, 1991
17 Park M, Dean M, Cooper CS, Schmidt M, O'Brien SJ, Blair DG, et al. : Mechanism of met oncogene activation. Cell 45 : 895-904, 1986   DOI   ScienceOn
18 Patil SR, Merrick S, Lubs HA : Identification of each human chromosome with a modified Giemsa stain. Science 173 : 821-822, 1971   DOI
19 Kleihues P, Louis DN, Scheithauer BW, Rorke LB, Reifenberger G, Burger PC, et al. : The WHO classification of tumors of the nervous system. J Neuropathol Exp Neurol 61 : 215-225; discussion 226-219, 2002
20 Lee JY, Finkelstein S, Hamilton RL, Rekha R, King JT Jr, Omalu B : Loss of heterozygosity analysis of benign, atypical, and anaplastic meningiomas. Neurosurgery 55 : 1163-1173, 2004   DOI   ScienceOn
21 Lee SH, Kim JH, Rhee CH, Kang YS, Lee JH, Choi KS : Loss of heterozygosity on chromosome 10, 13, 17, and p53 gene mutation in human brain gliomas. J Korean Neurosurg Soc 22 : 537-550, 1993
22 Leuraud P, Marie Y, Robin E, Huguet S, He J, Mokhtari K, et al. : Frequent loss of 1p32 region but no mutation of the p18 tumor suppressor gene in meningiomas. J Neurooncol 50 : 207-213, 2000   DOI   ScienceOn
23 Bhargava M, Joseph A, Knesel J, Halaban R, Li Y, Pang S, et al. : Scatter factor and hepatocyte growth factor : activities, properties, and mechanism. Cell Growth Differ 3 : 11-20, 1992
24 Liu Y : The human hepatocyte growth factor receptor gene : complete structural organization and promoter characterization. Gene 215 : 159-169, 1998   DOI   ScienceOn
25 Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A, et al. : The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol 114 : 97-109, 2007   DOI   ScienceOn
26 Mashiyama S, Murakami Y, Yoshimoto T, Sekiya T, Hayashi K : Detection of p53 gene mutations in human brain tumors by single-strand conformation polymorphism analysis of polymerase chain reaction products. Oncogene 6 : 1313-1318, 1991
27 Bozzetti C, Bortesi B, Merisio C : Loss of heterozygosity (LOH) in ovarian cancer. Int J Gynaecol Obstet 85 : 294-295, 2004   DOI   ScienceOn
28 Cooper CS, Park M, Blair DG, Tainsky MA, Huebner K, Croce CM, et al. : Molecular cloning of a new transforming gene from a chemically transformed human cell line. Nature 311 : 29-33, 1984   DOI   ScienceOn
29 Hollstein M, Sidransky D, Vogelstein B, Harris CC : p53 mutations in human cancers. Science 253 : 49-53, 1991   DOI
30 Jeffers M, Rong S, Vande Woude GF : Enhanced tumorigenicity and invasion-metastasis by hepatocyte growth factor/scatter factor-met signalling in human cells concomitant with induction of the urokinase proteolysis network. Mol Cell Biol 16 : 1115-1125, 1996
31 Karamitopoulou E, Perentes E, Diamantis I : p53 protein expression in central nervous system tumors : an immunohistochemical study with CM1 polyvalent and DO-7 monoclonal antibodies. Acta Neuropathol (Berl) 85 : 611-616, 1993   DOI   ScienceOn
32 Kastan MB, Onyekwere O, Sidransky D, Vogelstein B, Craig RW : Participation of p53 protein in the cellular response to DNA damage. Cancer Res 51 : 6304-6311, 1991
33 Arrieta O, Garcia E, Guevara P, Garcia-Navarrete R, Ondarza R, Rembao D, et al. : Hepatocyte growth factor is associated with poor prognosis of malignant gliomas and is a predictor for recurrence of meningioma. Cancer 94 : 3210-3218, 2002   DOI   ScienceOn
34 Akagi K, Kurahashi H, Arita N, Hayakawa T, Monden M, Mori T, et al. : Deletion mapping of the long arm of chromosome 22 in human meningiomas. Int J Cancer 60 : 178-182, 1995   DOI   ScienceOn