Browse > Article
http://dx.doi.org/10.3340/jkns.2010.47.4.302

Simultaneous Occurrence of Hodgkin's Lymphoma and Langerhans Cell Histiocytosis of the Spine : A Rare Combination  

Hyun, Seung-Jae (Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine)
Rhim, Seung-Chul (Department of Neurosurgery, Asan Medical Center, University of Ulsan College of Medicine)
Huh, Joo-Ryung (Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine)
Publication Information
Journal of Korean Neurosurgical Society / v.47, no.4, 2010 , pp. 302-305 More about this Journal
Abstract
Hodgkin's disease presenting with spinal cord compression owing to extradural and bone involvement is extremely unusual. A 48-year-old man presented with progressive lower extremity weakness resulting from spinal cord compression attributable to an epidural mass in the thoracic vertebrae. The patient underwent decompressive surgery, and was then treated with chemotherapy for Langerhans cell histiocytosis. However, the disease progressed, and we performed second decompressive surgery with stabilization. Subsequent histopathological investigations revealed Hodgkin's lymphoma of the bone. Here, we describe an unusual case of spinal Hodgkin's lymphoma and Langerhans cell histiocytosis to draw attention to this combination as a possible diagnosis in patients with mixed inflammatory cell infiltrate lesions in the spine.
Keywords
Hodgkin's disease; Lymphoma; Langerhans cell histiocytosis; Spinal cord compression;
Citations & Related Records

Times Cited By Web Of Science : 0  (Related Records In Web of Science)
Times Cited By SCOPUS : 0
연도 인용수 순위
  • Reference
1 Egeler RM, Neglia JP, Puccetti DM, Brennan CA, Nesbit ME : Association of Langerhans cell histiocytosis with malignant neoplasm. Cancer 71 : 865-873, 1993   DOI   ScienceOn
2 Love JG, Miller RH, Kernohan JW : Lymphomas of spinal epidural space. AMA Arch Surg 69 : 66-76, 1954   DOI
3 Perry JR, Deodhare SS, Bilbao JM, Murray D, Muller P : The significance of spinal cord compression as the initial manifestation of lymphoma. Neurosurgery 32 : 157-162, 1993   DOI   ScienceOn
4 Sapozink MD, Kaplan HS : Intracranial Hodgkin's disease. A report of 12 cases and review of the literature. Cancer 52 : 1301-1307, 1983   DOI   ScienceOn
5 Ultmann JE, DeVita VT Jr : Hodgkin's disease and other lymphomas. In : Harrison's Principles of Internal Medicine,10th eds. New York : McGraw-Hill, 1983, pp140-149
6 Wood NL, Coltman CA : Localized primary extranodal Hodgkin's disease. Ann Intern Med 78 : 113-118, 1973   DOI   ScienceOn
7 Karadeniz C, Sarialioglu F, Gogus S, Akyuz C, Kugukali T, Kutluk T, et al. : Multiple primary malignancy : a report on Langerhans cell histiocytosis associated with Hodgkin's disease. Turk J Pediatr 33 : 185-190, 1991
8 Michetti G, Cottini M, Scelsi L, Pugliese C, Minio A, Arnone P, et al. : Langerhans' cell granulomatosis and Hodgkin's lymphoma. Report of a case. Minerva Med 87 : 243-247, 1996
9 Levitt LJ, Dawson DM, Rosenthal DS, Moloney WC : CNS involvement in the non-Hodgkin's lymphomas. Cancer 45 : 545-552, 1980   DOI   ScienceOn
10 Neumann MP, Frizzera G : The coexistence of Langerhans' cell granulomatosis and malignant lymphoma may take different forms : report of seven cases with a review of the literature. Hum Pathol 17 : 1060-1065, 1986   DOI   ScienceOn
11 Freeman C, Berg JW, Cutler SJ : Occurrence and prognosis of extranodal lymphomas. Cancer 29 : 252-260, 1972   DOI   ScienceOn
12 Fried G, Ben Arieh Y, Haim N, Dale J, Stein M : Primary Hodgkin's disease of the bone. Med Pediatr Oncol 24 : 204-207, 1995   DOI   ScienceOn
13 Herman TS, Hammond N, Jones SE, Butler JJ, Byrne GE Jr, McKelvey EM : Involvement of the central nervous system by non- Hodgkin's lymphoma : The Southwest Oncology Group experience. Cancer 43 : 390-397, 1979   DOI   ScienceOn
14 Drake RL : Lymphosarcoma involving the epidural space. J Kans Med Soc 42 : 212-222, 1941
15 Bender BL, Mayernik DG : Hodgkin's disease presenting with isolated craniospinal involvement. Cancer 58 : 1745-1748, 1986   DOI   ScienceOn