Browse > Article
http://dx.doi.org/10.3340/jkns.2008.43.4.194

Cerebellar Glioblastoma Multiforme in an Adult  

Hur, Hyuk (Department of Neurosurgery Chonnam National University Hwasun Hospital & Medical School)
Jung, Shin (Department of Neurosurgery Chonnam National University Hwasun Hospital & Medical School)
Jung, Tae-Young (Department of Neurosurgery Chonnam National University Hwasun Hospital & Medical School)
Kim, In-Young (Department of Neurosurgery Chonnam National University Hwasun Hospital & Medical School)
Publication Information
Journal of Korean Neurosurgical Society / v.43, no.4, 2008 , pp. 194-197 More about this Journal
Abstract
Primary cerebellar glioblastoma multiforme (GBM) is a rare tumor in adults that accounts for just 1% of all cases of GBM. Due to their rarity, cerebellar GBMs are not yet completely understood about the pathogenesis and the prognosis. Here, we present a case of GBM in a 69-year-old man. Neurologic examination revealed the presence of cerebellar signs. Magnetic resonance imaging (MRI) showed a 4.5${\times}$3.6 cm-sized, ill-defined, heterogeneously enhancing mass in the left cerebellum and two patchy hyperintense lesions in the right cerebellum with minimal enhancement. After operation, glioblastoma was histologically confrimed. Postoperative radiotherapy with concomittent and adjuvant temozolomide chemotherapy was subsequently followed. Here, a case of unusual GBM in the cerebellum is reported with review of literature regarding the pathogenesis, the differential diagnosis and prognosis. There was no evidence of recurrence during postoperative one year. This patient showed a good prognosis in spite of the multiple lesions.
Keywords
Cerebellum; Differential diagnosis; Glioblastoma multiforme; Pathogenesis;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
Times Cited By Web Of Science : 1  (Related Records In Web of Science)
Times Cited By SCOPUS : 0
연도 인용수 순위
1 Zito JL, Siva A, Smith TW, Leeds M, Davidson R : Glioblastoma of the cerebellum. Computed tomographic and pathologic considerations. Surg Neurol 19 : 373-378, 1983   DOI   ScienceOn
2 Bilaniuk LT : Adult infratentorial tumors. Semin Roentgenol 25 : 155-173, 1990
3 Demir MK, Hakan T, Akinci O, Berkman Z : Primary cerebellar glioblastoma multiforme. Diagn Interv Radiol 11 : 83-86, 2005   PUBMED
4 Joung YI, Cheong JH, Bak KH : Cerebellar Glioblastoma Presenting as a Cerebellar Hemorrhage in a Child, J Korean Neurosurg Soc 39 : 374-377, 2006   과학기술학회마을
5 Miller EM, Mani RL, Townsend JJ : Cerebellar glioblastoma multiforme in an adult. Surg Neurol 5 : 341-343, 1976   PUBMED
6 Tamaki T, Eguchi T, Sakamoto M, Teramoto A : Glioblastoma multiforme of the cerebellum in an elderly man. J Chin Med Assoc 67 : 301-304, 2004   PUBMED
7 Kuroiwa T, Numaguchi Y, Rothman MI, Zoarski GH, Morikawa M, Zagardo MT, et al : Posterior fossa glioblastoma multiforme : MR findings. AJNR Am J Neuroradiol 16 : 583-589, 1995   PUBMED
8 Rosenfeld J, Rossi ML, Briggs M : Glioblastoma multiforme of the cerebellum in an elderly man. A case report. Tumori 75 : 626-629, 1989   DOI   PUBMED
9 Schmidbauer M, Budka H, Bruckner R, Vorkapic P : Glioblastoma developing at the site of a cerebellar medulloblastoma treated 6 years earlier. Case report. J Neurosurg 67 : 915-918, 1987   DOI
10 Hegedus K, Molnar P : Primary cerebellar glioblastoma multiforme with an unusually long survival. Case report. J Neurosurg 58 : 589-592, 1983   DOI
11 Ushio Y, Arita N, Yoshimine T, Ikeda T, Mogami H : Malignant recurrence of childhood cerebellar astrocytoma : case report. Neurosurgery 21 : 251-255, 1987   DOI   PUBMED
12 Pombo R, Tortelly-Costa A, Bulacio E, Hahn MD, de Carvalho ML : [Cerebellar glioblastoma multiforme : report of a case in a child]. Arq Neuropsiquiatr 43 : 102-107, 1985   DOI   PUBMED   ScienceOn
13 Maat-Schieman ML, Bots GT, Thomeer RT, Vielvoye GJ : Malignant astrocytoma following radiotherapy for craniopharyngioma. Br J Radiol 58 : 480-482, 1985   DOI   ScienceOn
14 Law M, Cha S, Knopp EA, Johnson G, Arnett J, Litt AW : High-grade gliomas and solitary metastases : differentiation by using perfusion and proton spectroscopic MR imaging. Radiology 222 : 715-721, 2002   DOI   ScienceOn
15 Luccarelli G : Glioblastoma multiforme of the cerebellum : description of three cases. Acta Neurochir (Wien) 53 : 107-116, 1980   DOI
16 Lai PH, Ho JT, Chen WL, Hsu SS, Wang JS, Pan HB, et al : Brain abscess and necrotic brain tumor : discrimination with proton MR spectroscopy and diffusion-weighted imaging. AJNR Am J Neuroradiol 23 : 1369-1377, 2002   PUBMED
17 Occhiogrosso M, Spada A, Merlicco G, Vailati G, De Benedictis G : Malignant cerebellar astrocytoma. Report of five cases. J Neurosurg Sci 29 : 43-50, 1985   PUBMED
18 Aun RA, Stavale JN, Silva-Junior D : [Glioblastoma multiforme of the cerebellum. Report of a case]. Arq Neuropsiquiatr 39 : 350-354, 1981   DOI   PUBMED   ScienceOn
19 Kopelson G : Cerebellar glioblastoma. Cancer 50 : 308-311, 1982   DOI   ScienceOn
20 Wisoff HS, Llena JF : Glioblastoma multiforme of the cerebellum five decades after irradiation of a cerebellar tumor. J Neurooncol 7 : 339-344, 1989   DOI
21 Asato R, Okumura R, Konishi J : "Fogging effect" in MR of cerebral infarct. J Comput Assist Tomogr 15 : 160-162, 1991   DOI   PUBMED   ScienceOn
22 Kulkarni AV, Becker LE, Jay V, Armstrong DC, Drake JM : Primary cerebellar glioblastomas multiforme in children. Report of four cases. J Neurosurg 90 : 546-550, 1999   DOI   ScienceOn
23 Gusnard DA : Cerebellar neoplasm in children. Semin Roentgenol 25 : 263-278, 1990