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Treatment of Meningitis Caused by Vancomycin-Resistant Enterococcus with Synercid  

Oh, Hyung-Suk (Department of Neurosurgery, Kosin University College of Medicine)
Jeon, Byung-Chan (Department of Neurosurgery, Kosin University College of Medicine)
Kim, Young-Su (Department of Neurosurgery, Kosin University College of Medicine)
Chun, Tae-Sang (Department of Neurosurgery, Kosin University College of Medicine)
Publication Information
Journal of Korean Neurosurgical Society / v.39, no.2, 2006 , pp. 141-143 More about this Journal
Abstract
Vancomycin-resistant enterococci[VRE] are rare cause of meningitis, occurring in immunocompromised patients, severely ill, hospitalized patient, and patients who have undergone neurosurgical procedures. Resistance to vancomycin has increased in frequency during the past few years. Limited therapeutic options are available for VRE infectionsandtheoptimumtherapy has not been established. We report a case of VRE meningitis that was successfully treated with administration of quinupristin-dalfopristin [Synercid] by both intravenous and intraventricular routes. A brief review of the literature is provided, which indicates that optimal management with Synercid should include daily intraventricular doses of at least 2mg and intravenous 0.5mg/kg every 8 hours. We also review the previously reported cases of VRE meningitis.
Keywords
Vancomycin-resistant enterococcus; Ventriculitis; Quinupristin-dalfopristin;
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