Browse > Article

Neuropathic Pain Behaviors and the Change of Spinal Neuropeptides following Peripheral Nerve Injury in Neonatal Rats  

Yoon, Young-Sul (Department of Neurosurgery, Yonsei University College of Medicine)
Back, Seung-Keun (Department of Physiology, Medical Science Research Center, Korea University College of Medicine)
Kim, Hee-Jin (Department of Life Science, Yonsei University Wonju Campus College of Science)
Na, Heung-Sik (Department of Physiology, Medical Science Research Center, Korea University College of Medicine)
Publication Information
Journal of Korean Neurosurgical Society / v.39, no.1, 2006 , pp. 52-57 More about this Journal
Abstract
Objective : It has been suggested that the occurrence of persistent pain signal during the early postnatal period may alter an individual's response to pain later in life. The aim of this study is to assess whether neonatal nerve injury resulted in long-lasting consequences on nociceptive system in the rat. Methods : We examined whether neuropathic pain behaviors and the changes of spinal neuropeptides [SP, CGRP, VIP and VIP] induced by peripheral nerve injury within 1 day after birth [Neonate group] were different from those at 8 weeks after birth [Mature group]. Results : The Neonate group showed more robust and long-lasting pain behaviors than the Mature group. Immunohistochemical findings demonstrated that spinal SP- & CGRP-immunoreactivities[ir] of the ipsilateral to the contralateral side increased in the Neonate group, whereas those decreased in the Mature group. In addition, increase in spinal VIP- & NPY-ir of the ipsilateral to the contralateral side was more robust in the Mature group than in the Neonate group. Conclusion : These results suggest that peripheral nerve injury in the early postnatal period may result in long-lasting and potentially detrimental alterations in nociceptive pathways.
Keywords
Peripheral nerve injury; Neuropathic pain; Neonatal; Allodynia; Spinal neuropeptides;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Bennett GJ, Xie YK : A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain 33 : 87-107, 1988   DOI   ScienceOn
2 De Lima J, Alvares D, Hatch DJ, Fitzgerald M : Sensory hyperinnervation after neonatal skin wounding : effect of bupivacaine sciatic nerve block. Br J Anaesth 83 : 662-664, 1999   DOI   ScienceOn
3 Kim SH, Chung JM : An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. Pain 50 : 355-363, 1992   DOI   ScienceOn
4 Kim YI, Na HS, Han JS, Hong SK : Critical role of the capsaicin-sensitive nerve fibers in the development of the causalgic symptoms produced by transecting some but not all of the nerves innervating the rat tail. J Neuroscience 15 : 4133-4139, 1995   DOI
5 Kim HJ, Back SK, Kim J, Sung B, Hong SK, Na HS : Increases in spinal vasoactive intestinal polypeptide and neuropeptide Y are not sufficient for the genesis of neuropathic pain in rats. Neurosci Lett 342 : 109-113, 2003   DOI   ScienceOn
6 Naveilhan P, Hassani H, Lucas G, Blakeman KH, Hao JX, Xu XJ, et al : Ernfors P Reduced antinociception and plasma extravasation in mice lacking a neuropeptide Y receptor. Nature 409 : 513-517, 2001   DOI   ScienceOn
7 Reynolds ML, Fitzgerald M : Long-term sensory hyperinnervation following neonatal skin wounds. J Comp Neurol 358 : 487-498, 1995   DOI   ScienceOn
8 Ruda MA, Ling QD, Hohmann AG, Peng YB, Tachibana T : Altered nociceptive neuronal circuits after neonatal peripheral inflammation. Science 289 : 628-631, 2000   DOI   ScienceOn
9 Taddio A, Goldbach M, Ipp M, Stevens B, Koren G : Effect of neonatal circumcision on pain responses during vaccination in boys. Lancet 345 : 291-292, 1995   DOI   ScienceOn
10 Woolf CJ : A new strategy for the treatment of inflammatory pain. Prevention or elimination of central sensitization. Drugs 47 : 1-9, 1994
11 Anand KJ : Pain, plasticity, and premature birth : a prescription for permanent suffering? Nat Med 6 : 971-973, 2000   DOI   ScienceOn
12 Alvares D, Torsney C, Beland B, Reynolds M, Fitzgerald M : Modeling the prolonged effects of neonatal pain. Prog Brain Res 129 : 365-373, 2000   DOI
13 Seltzer Z, Dubner R, Shir Y : A novel behavioral model of neuropathic pain disorders produced in rats by partial sciatic nerve injury. Pain 43 : 205-218, 1990   DOI   ScienceOn
14 Torsney C, Fitzgerald M : Spinal dorsal horn cell receptive field size is increased in adult rats following neonatal hindpaw skin injury. J Physiol 50 : 255-261, 2003
15 Na HS, Han JS, Ko KH, Hong SK : A behavioral model for peripheral neuropathy produced in rat's tail by inferior caudal trunk injury. Neurosci Lett 177 : 50-52, 1994   DOI   ScienceOn
16 Taddio A, Stevens B, Craig K, Rastogi P, Ben-David S, Shennan A, et al : Efficacy and safety of lidocaine-prilocaine cream for pain during circumcision. N Engl J Med 336 : 1197-1201, 1997   DOI   ScienceOn
17 Fitzgerald M, Beggs S : The neurobiology of pain : developmental aspects. Neuroscientist 7 : 246-257, 2001   DOI   ScienceOn
18 Grunau RV, Whitfield MF, Petrie JH : Pain sensitivity and temperament in extremely low-birth-weight premature toddlers and preterm and full-term controls. Pain 58 : 341-346, 1994   DOI   ScienceOn
19 Na HS, Kim HJ, Sung B, Back SK, Kim DY, Kim JS, et al : Decrease in spinal CGRP and substance P is not related to neuropathic pain in a rat model. Neuroreport 12 : 175-178, 2001   DOI   ScienceOn
20 Reynolds ML, Fitzgerald M : Neonatal sciatic nerve section results in thiamine monophosphate but not substance P or calcitonin gene-related peptide depletion from the terminal field in the dorsal horn of the rat : the role of collateral sprouting. Neuroscience 51 : 191-202, 1992   DOI   ScienceOn
21 Kozin F, Haughton V, Ryan L : The reflex sympathetic dystrophy syndrome in a child. J Pediatr 90 : 417-419, 1977   DOI
22 Himes BT, Tessler A : Death of some dorsal root ganglion neurons and plasticity of others following sciatic nerve section in adult and neonatal rats. J Comp Neurol 284 : 215-230, 1989   DOI   ScienceOn
23 Porter FL, Grunau RE, Anand KJ : Long-term effects of pain in infants. J Dev Behav Pediatr 20 : 253-261, 1999   DOI