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Establishment of the Analytical Method for Residual Pharmaceuticals in Raw Water Using Online Sample Preparation and High Resolution Orbitrap LC/ESI-MS  

Hwang, Yoonjung (Water Quality Research Institute)
Sin, Sanghee (Water Quality Research Institute)
Park, Jongsuk (Water Quality Research Institute)
Publication Information
Journal of Korean Society on Water Environment / v.29, no.3, 2013 , pp. 409-419 More about this Journal
Abstract
In this study, the analytical method for 27 residual pharmaceuticals in raw water was developed. Online sample preconcentration/extraction and analysis with high resolution Orbitrap mass spectrometry (LC-ESI/Orbitrap MS) were performed. The calibration curves showed good linearities (above $r^2$ = 0.998) in the range of 5 ~ 1,000 ng/L. The method detection limit and the limit of quantification were 1.1 ~ 10.0 ng/L and 3.4 ~ 31.7 ng/L, respectively. Recoveries of the target compounds were between 70.1% and 115.8% (except cefadroxil, cefradine, vancomycin, and iopromide (50.2 ~ 67.0%)). The optimized analytical method can be useful to determine the residual pharmaceuticals in raw water.
Keywords
High resolution; Online sample preconcentration; LC-ESI/Orbitrap MS; Residual pharmaceuticals;
Citations & Related Records
Times Cited By KSCI : 3  (Citation Analysis)
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