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Reduction of Estrogenic Activity by Gamma-ray Treatment  

Kang, Sung-Wook (Division of Environmental Science & Ecological Engineering, Korea University)
Seo, Jaehwan (Division of Environmental Science & Ecological Engineering, Korea University)
Lee, Byoung Cheun (Risk Assessment Division, National Institute of Environmental Research)
Kim, Suejin (Risk Assessment Division, National Institute of Environmental Research)
Jung, Jinho (Division of Environmental Science & Ecological Engineering, Korea University)
Publication Information
Journal of Korean Society on Water Environment / v.26, no.6, 2010 , pp. 948-953 More about this Journal
Abstract
In this study, degradation of estrone (E1) and $17{\alpha}$-ethynylestradiol (EE2) by gamma-irradiation and subsequent reduction of estrogenic activity as a function of absorbed dose were conducted using the yeast two-hybrid assay. Relative potency of E1 and EE2 compared to estrogenic activity of $17{\beta}$-estradiol (E2) was found to be 0.0144 and 0.1605, respectively. More than 90% of E1 and EE2 (both $5.0{\times}10^{-6}M$) was removed at an absorbed dose of 5 kGy, but more than 40% of estrogenic activity still remained. The addition of $TiO_2$ catalyst appeared to improve the removal efficiency of E1 and decrease estrogenic activity while there was no significant effect for EE2. Additionally, the calculated estrogenic activity of E1 and EE2 based on a regression model was well correlated with the observed activity.
Keywords
Endocrine disrupting chemicals; Estrogenic activity; Radiation treatment; Yeast two-hybrid assay;
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Times Cited By KSCI : 5  (Citation Analysis)
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