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http://dx.doi.org/10.5762/KAIS.2021.22.4.504

The Effects of Gobonyangjeonbang Administration on Reproductive Toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induced Rats.  

OH, Ji Hye (Department of Biomedical Laboratory Science, Daejeon University)
Yang, Dong Hyun (Department of Biomedical Laboratory Science, Daejeon University)
Park, Un kyu (Department of Biomedical Laboratory Science, Daejeon University)
Cho, Chung Sik (Department of Korean Medicine, Daejeon University)
Hwang, Seock Yeon (Department of Biomedical Laboratory Science, Daejeon University)
Publication Information
Journal of the Korea Academia-Industrial cooperation Society / v.22, no.4, 2021 , pp. 504-512 More about this Journal
Abstract
Sperm formation disorders and sperm quality degradation comprises the largest proportion of male infertility caused by TCDD. To solve this problem, this study examined the effects of Gobonyangjeonbang oriental medicine prescription on the endocrine function and reproductive toxicity-related indicators in rat-induced TCDD-induced reproductive. Male SD rats were divided into five groups of seven animals and tested. The normal control group was administered the vehicle and saline, the TCDD alone group was administered intraperitoneally with TCDD (2 ㎍/kg, weeks) and physiological saline, and the test group was administered orally by dividing GYB (75, 150, and 300 mg/kg) into three concentrations for six weeks. Weight loss was observed in all groups administered TCDD. Regarding the hormonal changes, a significant decrease in free testosterone was observed in the GYB 300 mg/kg group (p<0.01). In addition, some of the germ cell destruction, seminiferous tubular atrophy, and decrease in sperm count was improved in a concentration-dependent manner in the testicular tissue of the GYB-treated group. In addition, Johnsen's score and serotoli cell index (SCI) were improved in a concentration-dependent manner (p<0.05). Overall, GYB can be used in drug therapy rather than medical procedures to solve male infertility in the future.
Keywords
Gobonyangjeonbang (GYB); Reproductive toxicity; Serotoli cell; TCDD; Testosterone;
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Times Cited By KSCI : 3  (Citation Analysis)
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