Generation of a transgenic pig expressing human dipeptidylpeptidase-4 (DPP-4)
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Chung, Hak Jae
(Swine Science Division, National Institute of Animal Science, Rural Development Administration)
Sa, Soo Jin (Swine Science Division, National Institute of Animal Science, Rural Development Administration) Baek, Sun Young (Swine Science Division, National Institute of Animal Science, Rural Development Administration) Cho, Eun Suek (Swine Science Division, National Institute of Animal Science, Rural Development Administration) Kim, Young Shin (Swine Science Division, National Institute of Animal Science, Rural Development Administration) Hong, Jun Ki (Swine Science Division, National Institute of Animal Science, Rural Development Administration) Cho, Kyu Ho (Swine Science Division, National Institute of Animal Science, Rural Development Administration) Kim, Ji Youn (Animal Biotechnology Division, National Institute of Animal Science, Rural Development Administration) Park, Mi Ryung (Animal Biotechnology Division, National Institute of Animal Science, Rural Development Administration) Kim, Kyung Woon (Planning & Coordination Division, National Institute of Animal Science, Rural Development Administration) |
1 | H. C. Lee, H. M. Kim, S. Lee, K. B. Oh, H. J. Chung, B. C. Yang, K. W. Kim, P. Lee, J. K. Park, W. K. Chang. "Production of a Transgenic Pig Overexpressing Phosphoprotein Enriched in Astrocytes 15 (PEA 15)", Reproductive & Developmental Biology, vol. 35, pp. 239-245. 2011. |
2 | H. G. Lee, H. C. Lee, S. W. Kim, P. Lee, H. J. Chung, Y. K. Lee, J. H. Han, I. S. Hwang, J. I. Yoo, Y. K. Kim, H. T. Kim, H. T. Lee, W. K. Chang, J. K. Park. "Production of recombinant human von Willebrand factor in the milk of transgenic pigs", Journal of Reproduction and Development, vol. 55, pp. 484-490. 2009. DOI: http://dx.doi.org/10.1262/jrd.20212 DOI |
3 | L. D. Itz, F. Ishikawa, D. L. Greiner. "Humanized mice in translation biomedical research", Nature Reviews Immunology, vol. 7, pp. 118-130. 2007. DOI |
4 | I. H. Drespe, G. K. Polzhofer, A. S. Turner, Grauer JN. "Animal models for spinal fusion", The Spine Journal, vol. 5, pp. S209-S216. 2005. DOI: http://dx.doi.org/10.1016/j.spinee.2005.02.013 DOI |
5 | J. K. Lunney. "Advances in swine biomedical model genomics", International Journal of Biological Sciences, vol. 3, pp. 179-184. 2007. DOI: http://dx.doi.org/10.7150/ijbs.3.179 DOI |
6 | S. E. Kahn, R. L. Hull, K. M. Utzschneider. "Mechanisms linking obesity to insulin resistance and type 2 diabetes", Nature, vol. 444, pp. 840-846. 2006. DOI: http://dx.doi.org/10.1038/nature05482 DOI |
7 | G. Kloppel, M. Lohr, K. Habich, M. Oberholzer, P. U. Heitz. "Islet pathology and the pathogenesis of type 1 and type 2 diabetes mellitus revisited", Survey and Synthesis of Pathology Resesrch, vol.4, pp. 110-125. 1985. |
8 | Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. "Report of the expert committee on the diagnosis and classification of diabetes mellitus", Diabetes Care, vol. 26, pp. S5-S20. 2003. DOI |
9 | M. A. Nauck, E. Homberger, E. G. Siegel, R. C. Allen, R. P. Eaton, R. Ebert, W. Creutzfeldt. "Incretin effects of increasing glucose loads in man calculated from venous insulin and C-peptide responses", The Journal of Clinical Endocrinology and Metabolism, vol. 63, pp. 492-498. 1986. DOI: http://dx.doi.org/10.1210/jcem-63-2-492 DOI |
10 | J. P. Despres, I. Lemieux. "Abdominal obesity and metabolic syndrome", Nature, vol. 444, pp. 881-887. 2006. DOI: http://dx.doi.org/10.1038/nature05488 DOI |
11 | D. J. Drucker. "The biology of incretin hormones", Cell Metabolism, vol. 3, pp. 153-165. 2006. DOI: http://dx.doi.org/10.1016/j.cmet.2006.01.004 DOI |
12 | J. R. Ussher, D. J. Drucker. "Cardiovascular biology of the incretin system", Endocrine Reviews, vol. 33, pp. 187-215. 2012. DOI: http://dx.doi.org/10.1210/er.2011-1052 DOI |
13 | R. Yazbeck, G. S. Howarth, C. A. Abbott. "Dipeptidyl peptidase inhibitors, an emerging drug class for inflammatory disease?", Trends in Pharmacological Sciences, vol. 30, pp. 600-607. 2009. DOI: http://dx.doi.org/10.1016/j.tips.2009.08.003 DOI |
14 | S. Blech, E. Ludwig-Schwellinger, E. U. Grafe-Mody, B. Withopf, K. Wagner. "The metabolism and disposition of the oral dipeptidyl peptidase-4 inhibitor, linagliptin, in humans", Drug Metabolism and Disposition, vol. 38, pp. 667-678. 2010. DOI: http://dx.doi.org/10.1124/dmd.109.031476 DOI |
15 | N. Matikainen, S. Mänttäri, A. Schweizer, A. Ulvestad, D. Mills, B. E. Dunning, J. E. Foley, M. R. Taskinen. "Vildagliptin therapy reduces postprandial intestinal triglyceride-rich lipoprotein particles in patients with type 2 diabetes", Diabetologia, vol. 49, pp. 2049-2057. 2006. DOI: http://dx.doi.org/10.1007/s00125-006-0340-2 DOI |
16 | A. J. Scheen, G. Charpentier, C. J. Ostgren, A. Hellqvist, I. Gause-Nilsson. "Efficacy and safety of saxagliptin in combination with metformin compared with sitagliptin in combination with metformin in adult patients with type 2 diabetes mellitus", Diabetes Metabolism Research and Reviews, vol. 26, pp. 540-549. 2010. DOI: http://dx.doi.org/10.1002/dmrr.1114 DOI |
17 | E. J. Rhee, W. Y. Lee, K. W. Min, V. K. Shivane, A. R. Sosale, H. C. Jang, C. H. Chung, I. S. Nam-Goong, J. A. Kim, S. W. Kim; Gemigliptin Study 006 Group. "Efficacy and safety of the dipeptidyl peptidase-4 inhibitor gemigliptin compared with sitagliptin added to ongoing metformin therapy in patients with type 2 diabetes inadequately controlled with metformin alone", Diabetes Obesity and Metabolism, vol. 15, pp. 523-530. 2013. DOI: http://dx.doi.org/10.1111/dom.12060 DOI |
18 | Y. L. He, R. Sabo, J. Campestrini, Y. Wang, M. Ligueros-Saylan, K. C. Lasseter, S. C. Dilzer, D. Howard, W. P. Dole. "The influence of hepatic impairment on the pharmacokinetics of the dipeptidyl peptidase IV (DPP-4) inhibitor vildagliptin", European Journal Clinical Pharmacology, vol. 63, pp. 677-686. 2007. DOI |
19 | B. Eliasson, D. Möller-Goede, K. Eeg-Olofsson, C. Wilson, J. Cederholm, P. Fleck, M. Diamant, M. R. Taskinen, U. Smith. "Lowering of postprandial lipids in individuals with type 2 diabetes treated with alogliptin and/or pioglitazone: a randomized double-blind placebo-controlled study", Diabetologia, vol. 55, pp. 915-925. 2012. DOI: http://dx.doi.org/10.1007/s00125-011-2447-3 DOI |
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