Browse > Article
http://dx.doi.org/10.5762/KAIS.2019.20.6.430

Effect of Dendropanax morbifera extract Addition on Chungkukjang on Immune Response of Mice  

Kim, Jin-Sol (Department of biology, Chosun University)
Cheong, Min-Ju (Department of Health Administration, Dongkang University)
Chung, Kyoung-A (Department of Clinical Pathology, Kwangju Health University)
Song, Seon-Young (Department of Skin & Beauty, Kwangju Health University)
Lee, Hyun-Hwa (Department of biology, Chosun University)
Publication Information
Journal of the Korea Academia-Industrial cooperation Society / v.20, no.6, 2019 , pp. 430-438 More about this Journal
Abstract
This study is to investigate increase immunomodulatory activity of Chungkukjang added with Dendropanax morbifera extract. There are four groups divided that Control, Dendropanax morbifera extract group, Chungkookjang group and Chungkukjang added to Dendropanax morbifera extract group which of five mouses each group. Their immunological characteristics were compared with either general Chungkukjang or non treated group in the tested male ICR mice. There were no significant difference in body weight and organ weight. In the plaque forming cell assay, Dendropanax morbifera extract 250 and 500 mg/kg groups measured significant increase over the control group. The values of lymphocytes were significantly increased in the Dendropanax morbifera extract 500 mg/kg group campared with the control group. In the general Chungkukjang 400 mg/kg added with Dendropanax morbifera extract 500 mg/kg group, total serum immunoglobulin G concentration was significantly higher than the control group and their spleen tissues observed proliferation of white puls. These results demonstrated that Chungkukjang Added with Dendropanax morbifera extract was provided enhance of immunomodulatory activity and suggest that it can be used as various functional foods, based on foods promote immune system health.
Keywords
Chungkukjang; Dendropanax morbifera; Immunomodulatory Activity; Immunoglobulin; Spleen;
Citations & Related Records
Times Cited By KSCI : 7  (Citation Analysis)
연도 인용수 순위
1 S. H. Park, M. J. Kim, G. E. Kim, S. Y. Park, K. Kim, "Immuno-enhancing effect of enzymatic extract of Sargassum coreanum using crude enzyme from Shewanella oneidensis PKA 100", Journal of the Korean Society of Food Science and Nutrition, Vol.46, No.8, pp.919-928, 2017. DOI: https://doi.org/10.3746/jkfn.2017.46.8.919   DOI
2 D. L. Mallery, W. A. McEwan, S. R. Bidgood, G. J. Towers, C. M. Johnson, "Antibodies mediate intracellular immunity through tripartite motif-containing 21 (TRIM21)", PNAS, Vol.107, No.46, pp.19985-19990, 2010. DOI: https://doi.org/10.1073/pnas.1014074107   DOI
3 A. Atala, D. J. Irvine, M. Moses, S. Shaunak, "Wound healing versus regeneration: role of the tissue environment in regenerative medicine", MRS Bulletin, Vol.35, No.8, pp.597-606, 2010. DOI: https://doi.org/10.1557/mrs2010.528   DOI
4 KABLSP. Histology, 6th ed. Korean medical publishing company, Korea, p254-255, 2017.
5 S. D. Lim, K. S. Seong, K. S. Kim, D. U. Han, "Effects of fermented milk with hot water extract from Acanthopanax senticosus and Codonopsis lanceolata on the immune status of mouse", Korean Journal of Food Science and Technology, Vol.39, No.3, pp.323-329, 2007.
6 J. Y. Son, H. Y. Choi, J. D. Kim, "Anticancer and Related Immunomodulatory Effects of Kwibi-tang on Non-small Cell Lung Carcinoma, NCI-H520, Xenograft Mice", The Journal of Internal Korean Medicine, Vol.33, No.4, pp.387-404, 2012.
7 J. Y. Hong, E. J. Kim, S. R. Shin, T. W. Kim, I. J. Lee, "Physicochemical properties of cheonggukjang containing Korean red ginseng and Rubus coreanum", Korean Journal of Food Preservation, Vol.15, No.6, 872-877, 2008.
8 S. Heo, H. K. Joo, S. K. Lee, "Isolation and identification of fibrinolytic bacteria from Korean traditional cheonggukjan", Applied Biological Chemistry, Vol.41, No.2, pp.119-124, 1998.
9 W. S. Cha, S. K. Bok, M. U. Kim, S. S. Chun, S. S. Choi, "Production and separation of anti-hypertensive peptide during cheonggukjang fermentation with Bacillus subtilis CH-1023", Applied Biological Chemistry, Vol.43, No.4 pp.247-252, 2000.
10 B. H. Sohn, Y. J. Song, K. H. Oh, "Fibrinolytic activity and characterization of Bacillus licheniformis HK-12 isolated from cheonggukjang", KSBB Journal, Vol.23, No.3, 251-256, 2008.
11 M. H. Ki, S. H. Kim, H. S. Cho, B. H. Park, "Quality characteristics of cheonggukjang added with peanut (Arachis hypogaea L.) powder", Korean J Food Preserv, Vol.23, No.4, pp.488-494 2016. DOI: http://dx.doi.org/10.11002/kjfp.2016.23.4.488   DOI
12 J. J. Lee, A. R. Kim, H. C. Chang, M. Y. Lee, "Antioxidative effects of chungkukjang preparation by adding solar salt", Korean Journal of Food Preservation, Vol.16, No.2, pp.238-245, 2009.
13 Y. K. Jung, Y. K. Lee, H. K. No, S. D. Kim, "Effect of sea tangle on fermentation and quality characteristics of Cheongbukjang", Korean Journal of Food Preservation, Vol.13, No.1, pp.95-101, 2006.
14 M. Lee, Y. G. Lee, J. I. Cho, K. C. Na, E. J. Hwang, "Preparation of cheonggukjang added onion (Allium cepa L.) and its antioxidative activity.", Korean Journal of Food Preservation, Vol.21, No.1, pp.46-54, 2014. DOI: https://doi.org/10.11002/kjfp.2014.21.1.46   DOI
15 S. H. Hwang, H. S. Chung, S. D. Kim, K. S. Youn, "Effect of Glycyrrhizia uralensis extract addition on the quality of cheonggukjan", J East Asian Soc Dietary Life, Vol.14, No.6, pp.571-575, 2004.
16 K. Lee, J. O. Jang, H. K. Yoon, M. S. Kim, "Antithrombotic activities of cheongkookjang and cheongkookjang fermented with green tea or mugwort", Korean Journal of Microbiology, Vol.43, No.3, pp.298-303, 2007.
17 J. M. Chung, S. H. Kim, S. S. Kim, "Population structure and emergence and growth dynamics of seedling and spatial distribution of Dendropanax morbifera LEV (Araliaceae)", Korean J Plant Res, Vol.11, No.3, pp.345-352, 1998.
18 B. S. Jeong, J. S. Jo, B. S. Pyo, B. Hwang, "Studies on the distribution of Dendropanax morbifera and component analysis of the golden lacquer", Korean Journal of Biotechnology and Bioengineering, Vol.10, No.4, pp.393-400, 1995.
19 K. P. Lim, Y. S. Kim, W. Y. Chung, "Studies on the Development of Traditional Korean Golden Varnish (Hwangchil)(I)-Anatomical Characterisitics and Chemical Composition of Wood and Exudates of Hwangchil-namu (Dendropanax morbifera)", J Korean Wood Sci Technol., Vol.25, No.3, pp.24-28, 1997.
20 S. A. Park, J. Park, C. I. Park, Y. J. Jie, Y. C. Hwang, "Cellular antioxidant activity and whitening effects of Dendropanax morbifera leaf extracts", Korean J Microbiol Biotechnol, Vol.41, No.4, pp.407-415, 2013. DOI: https://doi.org/10.4014/kjmb.1311.11001   DOI
21 J. S. Park, H. S. Na, "Properties of cheonggukjang tablet prepared with medicinal herb extracts", Korean J Food Preserv, Vol.18, No.2, pp.149-155, 2011. DOI: https://doi.org/10.11002/kjfp.2011.18.2.149   DOI
22 S. I. Lee, J. G. Shin, S. D. Kim, "Effect of Red Ginseng - Chungkukjang Extracts on Lipid Profiles of Serum in Alcohol Administered Diabetes - Induced Rats", J Korean Soc Food Sci Nutr, Vol.34, No.9, pp.1362-1366, 2005. DOI: http://dx.doi.org/10.3746/jkfn.2005.34.9.1362   DOI
23 B. S. Geetha, P. G. Latha, S. N. Mangalam, P. Remani, "In vivo approaches to investigate the immune response of plant-based anti tumour drug, Elephantopus scaber L", Annals of Pharmacology and Pharmaceutics, Vol.2, No.1, 1011, 2017.
24 W. Zhang, J. Y. Du, Z. Jiang, T. Okimura, T. Oda, "Ascophyllan purified from Ascophyllum nodosum induces Th1 and Tc1 immune responses by promoting dendritic cell maturation", Marine Drugs, Vol.12, No.7, pp.4148-4164, 2014. DOI: http://dx.doi.org/10.3390/md12074148   DOI
25 J. S. Lim, "Effect of immune function on the fermentation of Kimchi intake to append Acanthopanacis cortex extract in Balb/c mice", Thesis Collect Res Inst Korean Medicine, Vol.12, No.1, pp.1-9, 2003.
26 M. Jang, T. G. Lim, H. D. Hong, Y. K .Rhee, K.T. Kim, E. J. Lee, J. H. Lee, Y. J. Lee, Y. B. Kim, C. W. Cho. "Immuno-stimulatory Activities of a High Molecular Weight Fraction from Cynanchum wilfordii Radix Obtained by Ultrafiltration", Korean J. Food Sci. Technol. Vol.48, No.3, pp.268-274, 2016. DOI: http://dx.doi.org/10.9721/KJFST.2016.48.3.268   DOI
27 K. J. Im, S. B. Jang, D. Y. Yoo, "Anti-cancer effects of Dendropanax morbifera extract in MCF-7 and MDA-MB-231 cell", The Journal of Korean Obstetrics and Gynecology, Vol.28, No.2, pp.26-39, 2015. DOI: https://doi.org/10.15204/jkobgy.2015.28.2.026   DOI
28 J. Kim, H. S. Ryu, J. H. Shin, H. S. Kim, "In vitro and Ex vivo supplementation of Houttuynia cordata extract and immunomodulating effect in mice", Journal of the Korean Society of Food Science and Nutrition, Vol.34, No.2, pp.167-175, 2005. DOI: https://doi.org/10.3746/jkfn.2005.34.2.167   DOI
29 H. I. Moon, "Antidiebetic effects dendropanaxide from leaves of Dendropanax morbifera Leveille in normal and streptozotocin-induced diabetic rats", Human & experimental toxicology, Vol.30, No.8, pp.870-875, 2011. DOI: https://doi.org/10.1177/0960327110382131   DOI
30 T. K. Hyun, M. Kim, H. Lee, Y. Kim, E. Kim, J. S. Kim, "Evaluation of anti-oxidant and anti-cancer properties of Dendropanax morbifera Leveille", Food Chemistry, Vol.141, No.3, pp.1947-1955, 2013. DOI: https://doi.org/10.1016/j.foodchem.2013.05.021   DOI
31 Y. B. Jo, J. H. Lee, "A study on the effect of the Dendropanax Mobifera extract on anti-hypertensive", J Korea Academia-Industrial cooperation Society, Vol.17, No.11, pp.708-715, 2016. DOI: http://doi.org/10.5762/KAIS.2016.17.11.708   DOI
32 J. H. Lee, S. H. Nam, W. T. Seo, H. D. Yun, S. Y. Hong, "The production of surfactin during the fermentation of cheonggukjang by potential probiotic Bacillus subtilis CSY191 and the resultant growth suppression of MCF-7 human breast cancer cells", Food Chemistry, Vol.131, No.4, pp.1347-1354, 2012. DOI: https://doi.org/10.1016/j.foodchem.2011.09.133   DOI
33 T. K. Hyun, Y. J. Ko, E. H. Kim, I. M. Chung, J. S. Kim, "Anti-inflammatory activity and phenolic composition of Dendropanax morbifera leaf extracts", Industrial Crops and Products, Vol.74, pp.263-270, 2015. DOI: https://doi.org/10.1016/j.indcrop.2015.05.002   DOI
34 S. H. Lee, H. S. Lee, Y. S. Park, B. Hwang, H. Kim, "Screening of immune activation activities in the leaves of Dendropanax morbifera Lev", Korean Journal of Medicinal Crop Science, Vol.10, No.2, pp.109-115, 2002.
35 S. H. Kim, J. L. Yang, Y. S. Song, "Physiological functions of Chongkukjang", Food Indust. Nutr, Vol.4, No.2, pp.40-46, 1999.