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http://dx.doi.org/10.5762/KAIS.2019.20.2.286

Neuroprotective Effects of Kaempferol, Quercetin, and Its Glycosides by Regulation of Apoptosis  

Kim, Ji Hyun (Department of Food Science and Nutrition, Pusan National University)
Lee, Sanghyun (Department of Integrative Plant Science, Chung-Ang University)
Cho, Eun Ju (Department of Food Science and Nutrition, Pusan National University)
Kim, Hyun Young (Department of Food Science, Gyeongnam National University of Science and Technology)
Publication Information
Journal of the Korea Academia-Industrial cooperation Society / v.20, no.2, 2019 , pp. 286-293 More about this Journal
Abstract
Alzheimer's disease (AD) is a neurodegenerative disease caused by accumulation of amyloid beta ($A{\beta}$) in the brain. In the present study, we investigated the neuroprotective effects of four flavonoids such as kaempferol, kaempferol-3-O-glucoside, quercetin, and quercetin-3-${\beta}$-D-glucoside against neuronal apoptosis induced by $A{\beta}$ in SH-SY5Y neuronal cells. Treatment with $A{\beta}$ decreased cell viability compared to the non-treated normal group. However, treatment with the four flavonoids increased cell viability in SH-SY5Y cells treated with $A{\beta}$. In addition, we measured the expression of apoptosis-related proteins such as Bcl-2-associated X protein (Bax) and cleaved caspase-9. Treatment with the four flavonoids down-regulated Bax and cleaved caspase-9 in $A{\beta}$-treated SH-SY5Y neuronal cells. Overall, the results of the present study demonstrated the neuroprotective effect of flavonoids by anti-apoptotic activity in $A{\beta}$-induced SH-SY5Y neuronal cells. These results suggest that these four flavonoids would be useful therapeutic and prevention agents for AD.
Keywords
Amyloid beta; Kaempferol; Kaempferol-3-O-glucoside; Quercetin; Quercetin-3-${\beta}$-D-glucoside;
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