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http://dx.doi.org/10.5762/KAIS.2019.20.11.115

Analysis of Correlations among β-amyloid, Serum Lipid Levels, and Cognitive Function in the Elderly with Mild Alzheimer's Dementia  

Nam, Seung-Min (Department of Physical Therapy, Daegu University)
Lee, Do-Youn (Department of Physical Therapy, Daegu University)
Publication Information
Journal of the Korea Academia-Industrial cooperation Society / v.20, no.11, 2019 , pp. 115-120 More about this Journal
Abstract
This study was undertaken to determine the correlation between β-amyloid, serum lipid levels, and cognitive function in the elderly with mild Alzheimer's dementia. The study was conducted in December 2018, enrolling 45 elderly people with mild Alzheimer's disease. Blood analysis measured the β-amyloid and serum lipid levels, and cognitive function was measured using MMSE-K. The correlation between β-amyloid, serum lipid levels and cognitive function was determined using Pearson's correlation analysis. A significantly negative correlation was observed between the β-amyloid level and cognitive function (p<0.05). Furthermore, serum lipid levels and cognitive function also revealed a significantly negative correlation between TC and LDL levels (p<0.05). These results indicate that increasing levels of β-amyloid, TC, and LDL augments a negative correlation that decreases the cognitive function, signifying that management of pathologic factors related to dementia is important for the prevention and improvement of cognitive function in dementia patients.
Keywords
Alzheimer's Dementia; Cognitive Function; ${\beta}$-amyloid; Serum Lipid Level; Total cholesterol;
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