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http://dx.doi.org/10.5762/KAIS.2018.19.8.449

Relationship between White Matter Changes and Homocysteine Concentration in Healthy Adults  

Hur, Wook (Department of Neurology, Chosun University School of Medicine)
Kang, Hyun Goo (Department of Neurology, Chosun University School of Medicine)
Publication Information
Journal of the Korea Academia-Industrial cooperation Society / v.19, no.8, 2018 , pp. 449-455 More about this Journal
Abstract
This study was conducted to analyze the correlation between changes in white matter and homocysteine concentration through brain computed tomography of healthy 50-75 year old subjects without stroke or dementia history. We studied 722 out of 900 patients who underwent health screening at one hospital from 2016 to 2017. Based on the medical records, retrospective studies were conducted and analyzed using SPSS. A chi-square test, T-test and univariate logistic regression analysis were used for analysis. After the subjects were divided into the group with and without white matter changes, the population characteristics were analyzed. The mean age, homocysteine concentration and prevalence of hypertension and diabetes were higher and the duration of education was shorter in the group with white matter changes. In the group with white matter changes, the population increased as homocysteine concentration increased. When the odds ratio was compared based on the lowest group (Q1), age [p<0.001], hypertension [p<0.001] and hyperhomocysteinemia [p=0.021] were risk factors for white matter changes. We also identified modifiable risk factors such as hypertension and hyperhomocysteinemia to prevent complications of white matter changes. However, there has been no report of risk for the each causes of hyperhomocysteinemia and relationship between white matter changes and homocysteine concentration in Koreans. Therefore, large scale prospective studies are needed to better understand this topic.
Keywords
Age; Computed tomography; Homocysteine; Hypertension; Risk factor; White matter;
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