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http://dx.doi.org/10.5762/KAIS.2017.18.4.366

Effects of Exercise on Endothelial Progenitor Cells in Cardiovascular Disease Patients: A Systematic Review  

Kim, Ahrin (Department of Nursing, Cheongju University)
Yang, In-Suk (Department of Nursing, Kyungil University)
Publication Information
Journal of the Korea Academia-Industrial cooperation Society / v.18, no.4, 2017 , pp. 366-379 More about this Journal
Abstract
In this study, we performed a systematic review and meta-analysis to identify the effects of exercise on endothelial progenitor cells (EPCs) in patients with cardiovascular disease (CVD). We conducted database searches (Cochrane Library, PubMed, EMBASE, ScienceDirect, CINAHL, Scopus, KoreaMed, KISS, RISS, KMBASE) for the effect of exercise on cardiovascular disease, using heart disease, coronary artery disease, heart failure, cardiovascular disease, exercise, motor activity, rehabilitation, and endothelial progenitor cells as the keywords. Of the 539 studies identified, 9 met the inclusion and exclusion criteria. Comprehensive Meta-Analysis version 2.0 was used to analyze the effect size and the publication bias was checked with a funnel plot. Exercise was found to improve the VEGF (vascular endothelial growth factor), CD34+KDR+, and endothelial function, assessed via FMD (flow-mediated dilation), in the exercise vs. control groups, viz. 2.008 (95% CI 0.204-3.812), 1.399 (95% CI 0.310-2.489), and 1.881 (95% CI 0.848-2.914), respectively. Exercise improved the VEGF, number of EPCs, and endothelial function in the CVD patients. Considering the increasing prevalence and mortality rates for cardiovascular disease in Korea, the findings of this study that analyzed the effects of exercise on EPCs might provide guidelines for planning exercise interventions for patients with CVD.
Keywords
Cardiovascular disease; Cardiac rehabilitation; Endothelial progenitor cells; Exercise; Motor activity;
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