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http://dx.doi.org/10.5762/KAIS.2016.17.6.207

Effects of Lespedeza Caneata ethanol extract on the Liver, Kidneys of Lead administered Mice  

Chung, Kyoung-A (Dept. of Occupational Therapy Dongshin University)
Cheong, Min-Ju (Dept. of life science Chosun University)
Publication Information
Journal of the Korea Academia-Industrial cooperation Society / v.17, no.6, 2016 , pp. 207-214 More about this Journal
Abstract
This study determined the effect of Lespedeza Caneata extract on the livers and kidneys of lead-administered mice. The experimental groups were divided into a normal group, Pb 4W group, Pb-LC 4W group, Pb 8W group, and Pb-LC 8W group. The normal group was supplied single distilled water, and the pb group was provided distilled water in which lead acetate was dissolved at 1,000 ppm. The Pb-LC group was provided with lead as drinking water, and the Lespedeza Caneata was orally medicated at a concentration of 500 mg/kg daily. AST, ALT, and BUN enzyme activities and histological experiments on the livers and kidneys resulted in the following conclusions. AST, ALT, and BUN activities increased in the experimental group compared to the normal group and decreased more in the Pb-LC group than the pb group during the same period. The histological results reveal that portions of the livers and kidneys were deformed in the Pb 4W group, and most of the Pb 8W group experienced necrosis and deformation. pb-LC4W and Pb-LC 8W groups experienced less deformation than the Pb 4W and Pb 8W groups. During the same period, the Pb-LC group experienced less histological changes than the Pb group. These results suggest that Lespedeza Caneata extract may have some protective effect on hepatic tissue and renal tissue damage with lead-administered in mice.
Keywords
ALT; AST; BUN; lead acetate; Lespedeza Caneata extract; liver; kidney;
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