Browse > Article
http://dx.doi.org/10.5762/KAIS.2016.17.3.611

The Effect of Collagen Peptide Intake on UVB-induced Skin Damage in Hairless mice  

Shin, Hyun-Jun (Department of Genetic engineering, Collage of Life Sciences, Kyung Hee University)
Park, Jong il (Department of Genetic engineering, Collage of Life Sciences, Kyung Hee University)
Kwon, Chang-Ju (Ju Yeong NS CO., LTD)
Kim, Hwa young (Ju Yeong NS CO., LTD)
Inoue, Naoki (Peptide Division, Nitta Gelatin Inc.)
Koizumi, Seiko (Peptide Division, Nitta Gelatin Inc.)
Hwang, Jae Sung (Department of Genetic engineering, Collage of Life Sciences, Kyung Hee University)
Publication Information
Journal of the Korea Academia-Industrial cooperation Society / v.17, no.3, 2016 , pp. 611-621 More about this Journal
Abstract
This study examined the effects of collagen peptide intake extracted from the tilapia fish (TFCP) on UVB-induced skin in hairless mice. To cause photoaging, the hairless mice were exposed to UVB irradiation three times a week and TFCP was administered with 545 and 1090 mg/kg once a day for 12 weeks. The level of wrinkle formation, thickness of the skin, acute erythema, skin hydration, amount of hydroxyproline, expression of MMPs and filaggrin were measured. Wrinkle formation, thickness of the skin, and acute erythema were significantly lower and skin hydration was higher in the TFCP intake group compared to the UVB-control mice group. In addition, the amount of the collagen and hydroxyproline of the collagen peptide intake group were much higher than the UVB-control group. Oral administration of TFCP inhibited the expression of the MMP-3 and MMP-13 mRNA level as well as activated MMP-2 and MMP-9 induced by UV irradiation, and increased the protein expression of filaggrin in hairless mice skin. In summary, the oral administration of TFCP can inhibit wrinkle formation and protect the skin from UV-damage. Therefore, this study suggests that TFCP is a potential candidate material for skin functional foods.
Keywords
Collagen; TFCP; Matrix metalloproteinase; Skin hydration; Wrinkle;
Citations & Related Records
Times Cited By KSCI : 6  (Citation Analysis)
연도 인용수 순위
1 J. H. Lee, B. S. Lee, B. S. Byun, W. G. Kim, S. J. Lee, Y. C. Sim, B. H. Kim. Effect of APB-01 on the Ultraviolet-Induced Photoaging and Wrinkle Formation in the Hairless Mice. J. Toxicol. Pub. Health. 19: pp. 303-310, 2003
2 J. K. Kim, J. H. Lee, M. S. Yang, D. B. Seo, S. J. Lee. Beneficial Effect of Collagen Peptide Supplement on Anti-aging Against Photodamage. Korean J. Food Sci. Technol. 41: pp. 441-445, 2009
3 M. Tanaka, Y. Koyama, Y. Nomura. Effects of collagen peptide ingestion on UV-B-induced skin damage. Bioscience, biotechnology, and biochemistry. 73: pp. 930-932, 2009. DOI: http://dx.doi.org/10.1271/bbb.80649   DOI
4 K. Scharffetter-Kochanek, P. Brenneisen, J. Wenk, G. Herrmann, W. Ma, L. Kuhr, C. Meewes, M. Wlaschek. Photoaging of the skin from phenotype to mechanisms. Experimental gerontology. 35: pp. 307-316, 2000. DOI: http://dx.doi.org/10.1016/S0531-5565(00)00098-X   DOI
5 K. J. Park, S. H. Park, J. K. Kim. Anti-wrinkle Activity of Acanthopanax senticosus Extract in Ultraviolet B (UVB)-induced Photoaging. J Korean Soc Food Sci Nutr., 39: pp. 42-46, 2010. DOI: http://dx.doi.org/10.3746/jkfn.2010.39.1.042   DOI
6 J. J. Li, Z. Dong, M. I. Dawson, N. H. Colburn. Inhibition of tumor promoter-induced transformation by retinoids that transrepress AP-1 without transactivating retinoic acid response element. Cancer research. 56: pp. 483-489, 1996.
7 C. Huang, W. Y. Ma, M. I. Dawson, M. Rincon, R. A. Flavell, Z. Dong. Blocking activator protein-1 activity, but not activating retinoic acid response element, is required for the antitumor promotion effect of retinoic acid. PNAS. 94: pp. 5826-5830, 1997. DOI: http://dx.doi.org/10.1073/pnas.94.11.5826   DOI
8 F. Takashi, O. Takahiro, Y. Naomi, W. Masanori, I. Takao, I. Katsumi. Effects of amla extract and collagen peptide on UVB-induced photoaging in hairless mice. Journal of functional foods. 5: pp. 451-459, 2013. DOI: http://dx.doi.org/10.1016/j.jff.2012.11.018   DOI
9 M. Sumiyoshi, T. Hayashi, Y. Kimura. Effects of the nonsugar fraction of brown sugar on chronic ultraviolet B irradiation-induced photoaging in melanin-possessing hairless mice. Journal of natural medicines. 63: pp. 130-136, 2009. DOI: http://dx.doi.org/10.1007/s11418-008-0301-9   DOI
10 M. Adam, P. Spacek, H. Hulejova, A. Galianova, J. Blahos. [Postmenopausal osteoporosis Treatment with calcitonin and a diet rich in cartilage proteins]. Casopislekaruceskych. 135: pp. 74-78, 1996.
11 M. C. Kwon, Syed Abdul Qadir, H. S. Kim, J. H. Ahn, N. H. Cho, H. Y. Lee. UV Protection and Whitening Effects of Collagen Isolated from Outer Layer of the Squid Todarodes pacificus. J. Kor. Fish. Soc. 41: pp. 7-12, 2008.
12 J. H. Chung, J. Y. Seo, H. R. Choi, M. K. Lee, C. S. Youn, G. Rhie, K. H. Cho, K. H. Kim, K. C. Park, H. C. Eun. Modulation of skin collagen metabolism in aged and photoaged human skin in vivo. J Invest Dermatol. 117: pp. 1218-1224, 2001. DOI: http://dx.doi.org/10.1046/j.0022-202x.2001.01544.x   DOI
13 H. B. Pyun, M. Kim, J. Park, Y. Sakai, N. Numata, J. Y. Shin, H. J. Shin, D. U. Kim, J. K. Hwang. Effects of Collagen Tripeptide Supplement on Photoaging and Epidermal Skin Barrier in UVB-exposed Hairless Mice. Prev Nutr Food Sci.17: pp. 245-253, 2012. DOI: http://dx.doi.org/10.3746/pnf.2012.17.4.245   DOI
14 S. E. Fligiel, J. Varani, S. C. Datta, S. Kang, G. J. Fisher, J. J. Voorhees. Collagen degradation in aged/photodamaged skin in vivo and after exposure to matrix metalloproteinase-1 in vitro. J Invest Dermatol. 120: pp. 842-848, 2003. DOI: http://dx.doi.org/10.1046/j.1523-1747.2003.12148.x   DOI
15 S. Inomata, Y. Matsunaga, S. Amano, K. Takada, K. Kobayashi, M. Tsunenaga, T. Nishiyama, Y. Kohno, M. Fukuda. Possible involvement of gelatinases in basement membrane damage and wrinkle formation in chronically ultraviolet B-exposed hairless mouse. J Invest Dermatol. 120: pp. 128-134, 2003. DOI: http://dx.doi.org/10.1046/j.1523-1747.2003.12021.x   DOI
16 H. Birkedal-Hansen. Proteolytic remodeling of extracellular matrix. Current opinion in cell biology. 7: pp. 728-735, 1995. DOI: http://dx.doi.org/10.1016/0955-0674(95)80116-2   DOI
17 C. H. Park, M. J. Lee, J. Ahn, S. Kim, H. H. Kim, K. H. Kim, H. C. Eun, J. H. Chung. Heat shock-induced matrix metalloproteinase (MMP)-1 and MMP-3 are mediated through ERK and JNK activation and via an autocrine interleukin-6 loop. J Invest Dermatol. 123: pp. 1012-1019, 2004. DOI: http://dx.doi.org/10.1111/j.0022-202X.2004.23487.x   DOI
18 C. Oba, H. Ohara, M. Morifuji, K. Ito, S. Ichikawa, K. Kawahata, J. Koga. Collagen hydrolysate intake improves the loss of epidermal barrier function and skin elasticity induced by UVB irradiation in hairless mice. Photodermatology, photoimmunology & photomedicine. 29: pp. 204-211, 2013. DOI: http://dx.doi.org/10.1111/phpp. 12051   DOI
19 H. H. Kim, M. J. Lee, S. R. Lee, K. H. Kim, K. H. Cho, H. C. Eun, J. H. Chung. Augmentation of UV-induced skin wrinkling by infrared irradiation in hairless mice. Mechanisms of ageing and development. 126: pp. 1170-1177, 2005. DOI: http://dx.doi.org/10.1016/j.mad.2005.06.003   DOI
20 Biniek K, Levi K, Dauskardt RH. Solar UV radiation reduces the barrier function of human skin. PNAS. 109: pp. 17111-17116, 2012. DOI: http://dx.doi.org/10.1073/pnas.1206851109   DOI
21 M. Brennan, H. Bhatti, K. C. Nerusu, N. Bhagavathula, S. Kang, G. J. Fisher, J. Varani, J. J. Voorhees. Matrix metalloproteinase-1 is the major collagenolytic enzyme responsible for collagen damage in UV-irradiated human skin. Photochemistry and photobiology. 78: pp. 43-48, 2003. DOI: http://dx.doi.org/10.1562/0031-8655(2003)0780043 MMITMC2.0.CO2   DOI
22 C. Cheng, D. Tempel, R. van Haperen, L. van Damme, M. Algur, R. Krams, R. de Crom. Activation of MMP8 and MMP13 by angiotensin II correlates to severe intra-plaque hemorrhages and collagen breakdown in atherosclerotic lesions with a vulnerable phenotype. Atherosclerosis. 204: pp. 26-33, 2009. DOI: http://dx.doi.org/10.1016/j.atherosclerosis.2009.01.025   DOI
23 S. R. Kim, Y. R. Jung, H. J. An, D. H. Kim, E. J. Jang, Y. J. Choi, K. M. Moon, M. H. Park, C. H. Park, K. W. Chung, H. R. Bae, Y. W. Choi, N. D. Kim, H. Y. Chung. Anti-wrinkle and anti-inflammatory effects of active garlic components and the inhibition of MMPs via NF-kappaB signaling. PloS one. 8:e73877, 2013. DOI: http://dx.doi.org/10.1371/journal.pone.0073877   DOI
24 B. Rechard. Function of filaggrin and caspase-14 information and maintenance of the epithelial barrier. Dermatol Sinica. 27: pp. 1-14, 2009.
25 S. J. Yang, J. H. Hong. Extraction and Physicochemical Properties of Collagen from Squid (Todarodes pacificus) skin and Alaska pollack (Theragra chalcogramma) skin. Korean J. Food Cookery Sci. 28: pp. 711-719, 2012. DOI: http://dx.doi.org/10.9724/kfcs.2012.28.6.711   DOI