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http://dx.doi.org/10.5762/KAIS.2016.17.2.58

Fabrication and characterization of 3-D porous scaffold by polycaprolactone  

Kim, Jin-Tae (Department of Advanced Material Engineering, Chungbuk National University)
Bang, Jung Wan (Department of Advanced Material Engineering, Seoul National University of Science and Technology)
Hyun, Chang-Yong (Department of Advanced Material Engineering, Seoul National University of Science and Technology)
Choi, Hyo Jeong (Department of Radiological Science, Kangwon National University)
Kim, Tae-Hyung (Department of Radiological Science, Kangwon National University)
Publication Information
Journal of the Korea Academia-Industrial cooperation Society / v.17, no.2, 2016 , pp. 58-65 More about this Journal
Abstract
This study was a preparatory experiment aimed the development of membrane scaffolds for tissue engineering. A PCL composite solution contained sodium chloride(NaCl). PCL porous membrane scaffolds were formed on a glass casting plate using a film applicator and immersed in distilled water to remove the NaCl reaching after drying. NaCl was used as a pore former for a 3 dimensional pore net-work. The dry condition parameters were $4^{\circ}C$, room temperature (RT) and $40^{\circ}C$ for each different temperatures in the drying experiment. SEM revealed the morphology of the pores in the membrane after drying and evaluated the in vitro cytotoxicity for basic bio-compatibility. The macro and micro pores existed together in the scaffold and showed a 3-dimensional pore net-working morphology at RT. The in vitro cytotoxicity test result was "grade 2" in accordance with the criterion for cytotoxicity by ISO 10993-5. The dry condition affected the formation of a 3 dimensional pore network and micro and macro pores. Therefore, these results are expected provide the basic process for the development of porous membrane scaffolds to control degradation and allow drug delivery.
Keywords
Polycaprolactone; Porosity; Salt leaching; Scaffold; 3-D porous;
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Times Cited By KSCI : 5  (Citation Analysis)
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