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http://dx.doi.org/10.5762/KAIS.2016.17.11.94

Association Between Liver Enzyme and Risk of All-Cause Mortality: Use of Korean Genome and Epidemiology Study (KoGES) Data  

Lee, Tae-Yong (Dept. of Preventive Medicine, Chungnam National University School of Medicine)
Ryu, Hyo-Sun (Dept. of Medical Administration & Information, Daejeon Health Institute of Technology)
Park, Chang-Soo (Dept. of Nuclear Medicine, Chungnam National University Hospital)
Publication Information
Journal of the Korea Academia-Industrial cooperation Society / v.17, no.11, 2016 , pp. 94-103 More about this Journal
Abstract
This study was conducted to investigate the association of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) with all-cause mortality among populations. The data used were from a Korean Genome and Epidemiology Study (KoGES) based on health examinations and questionnaires. The subjects consisted of 10,110 persons aged 40 and over. Hazard ratio was analyzed using Cox's proportional hazard model. The hazard ratio of AST (${\geq}50.0\;IU/L$) was 2.198 (95% CI: 1.217-3.971) after being adjusted for age, sex, education, regular exercise, smoking, drinking, WHR, and TG. In conclusion, AST was an independent significant risk factor of all-cause mortality, and ALT showed a tendency to increase. Overall, these findings indicate that AST and ALT may be useful tools for predicting mortality.
Keywords
KoGES; AST; ALT; All-cause mortality; Hazard ratio;
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