Browse > Article
http://dx.doi.org/10.5762/KAIS.2015.16.8.5452

Development of Anti-Wrinkle Materials using Galloyl-Peptide Derivatives  

Jung, Hae Soo (Anti-aging Research Institute of BIO-FD&C Co., Ltd.)
Song, Mi Young (Anti-aging Research Institute of BIO-FD&C Co., Ltd.)
Kim, Hyoung Sik (Anti-aging Research Institute of BIO-FD&C Co., Ltd.)
Seo, Hyo Hyun (Anti-aging Research Institute of BIO-FD&C Co., Ltd.)
Lee, Jeong Hun (Anti-aging Research Institute of BIO-FD&C Co., Ltd.)
Lee, Kyung Rok (AMI Cosmetic Co., Ltd.)
Hong, Il (AMI Cosmetic Co., Ltd.)
Moh, Sang Hyun (Anti-aging Research Institute of BIO-FD&C Co., Ltd.)
Publication Information
Journal of the Korea Academia-Industrial cooperation Society / v.16, no.8, 2015 , pp. 5452-5457 More about this Journal
Abstract
Conjugating a phytochemical, a strong antioxidant, with a functional peptide not only compensates for its stability, but also improves its solubility and anti-wrinkle effects, thereby contributing to the possibility of becoming an excellent cosmetic ingredient. Thus, in this study we examined the potential cosmetic use of a phytochemical-peptide derivative using gallic acid, a phytochemical with antioxidant, anti-inflammatory, and anti-cancer effects. To evaluate the antioxidant and wrinkle-improving efficacy of 5 synthesized gallic acids conjugated with LVH, IVH, KTTKS, YGGFM, and YGGFLRKYP respectively, we observed the expression of genes related to wrinkle improvement using DPPH radical scavenging activity and real-time PCR. As a result, all 5 derivatives had excellent free radical scavenging effects. The expression level of genes involved collagen synthesis also increased, and the secreted peptides during collagen production contributed to their antioxidant and wrinkle improving effects. These results mark the potential use of gallic acid peptide derivatives as a cosmetic ingredient for anti-oxidation and wrinkle improvement.
Keywords
Phytochemical; Gallic acid; Galloyl derivatives; Anti-Oxidant effect; Anti-Wrinkle effect;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Kasture VS, Sahu RK, Anjan K, Musmade DS, "Synthesis and antiparkinson activity of Gallic acid derivatives" Medicinal Chemistry and Drug Discovery, 3(2), pp. 134-139, 2012.
2 Reynolds LD, Wilson NG "Scribes and Scholars" 3rd edition, Oxford University Press, pp. 193-194, 1991.
3 Nguyen DM, Seo DJ, Lee HB, Kim IS, Kim KY, Park RD, Jung WJ, "Antifungal activity of gallic acid purified from Terminalia nigrovenulosa bark against Fusarium solani." Microb Pathog 56, pp. 8-15, 2013. DOI: http://dx.doi.org/10.1016/j.micpath.2013.01.001   DOI
4 Choi HJ, Song JH, Park KS, Baek SH, "In vitro anti-enterovirus 71 activity of gallic acid from Woodfordia fruticosa flowers." Lett Appl Microbiol 50, pp. 438-440, 2010. DOI: http://dx.doi.org/10.1111/j.1472-765X.2010.02805.x   DOI
5 Liu Z, Ma LP, Zhou B, Yang L, Liu ZL, "Antioxidative effects of green tea polyphenols on free radical initiated and photosensitized peroxidation of human low density lipoprotein." Chem Phys Lipids, 106(1), pp. 53-63, 2000. DOI: http://dx.doi.org/10.1016/S0009-3084(00)00133-X   DOI
6 Paolo R, "Peptides and Peptidomimetics in Medicinal Chemistry", Medicinal Chemistry and Drug Design, 8, pp. 978-953, 2012.
7 Hashimoto SI, Kyowa C, Hofu S, "Ribosome-independent Peptide Synthesis in Nature and Their Application to Dipeptide Production", J. Biol. Macromol, 8(2), pp. 28-37, 2008.
8 Ioannis, S., F. Demosthenes, V. Katerina, G. T. Andreas, K. Valentinos, B. Evangelos "Cyanobacterial cyclopeptides as lead compounds to novel targeted cancer drugs." Mar. Drugs, 8, pp. 629-657, 2010. DOI: http://dx.doi.org/10.3390/md8030629   DOI
9 Ruiz, M. A., B. Clares, M. E. Morales, and V. Gallardo, "Evaluation of the anti-wrinkle efficacy of cosmetic formulations with an anti-aging peptide." Ars. Pharm. 50, pp. 168-176, 2010.
10 Robinson, L. R., N. C. Fitzgerald, D. G. Doughty, N. C. Dawes, C. A. Berge, D. L. Bissett, "Topical palmitoyl pentapeptide provides improvement in photoaged human facial skin." J. Cosmetic science 27, pp. 155-160, 2005. DOI: http://dx.doi.org/10.1111/j.1467-2494.2005.00261.x   DOI
11 van Meerloo J1, Kaspers GJ, Cloos J, "Cell sensitivity assays: the MTT assay" Methods Mol Biol. 731, pp. 237-245, 2011. DOI: http://dx.doi.org/10.1007/978-1-61779-080-5_20   DOI
12 Takagi M, Nishioka M, Kakihara H, Kitabayashi M, Inoue H, Kawakami B, Oka M, Imanaka T, "Characterization of DNA polymerase from Pyrococcus sp. strain KOD1 and its application to PCR." Appl Environ Microbiol. 63(11), 4504-4510, 1997.
13 Fotakis G, Timbrell JA, "In vitro cytotoxicity assays: comparison of LDH, neutral red, MTT and protein assay in hepatoma cell lines following exposure to cadmium chloride." Toxicol Lett. 160, pp. 171-177, 2006. DOI: http://dx.doi.org/10.1016/j.toxlet.2005.07.001   DOI
14 Huang D, Ou B, Prior RL, "The chemistry behind antioxidant capacity assays." J Agric Food Chem. 53(6), pp. 1841-1856, 2005. DOI: http://dx.doi.org/10.1021/jf030723c   DOI
15 Imai J, Ide N, Nagae S, Moriguchi T, Matsuura H, Itakura Y, "Antioxidant and radical scavenging effects of aged garlic extract and its constituents." Planta Med., 60(5), 417-420, 1994. DOI: http://dx.doi.org/10.1055/s-2006-959522   DOI
16 Hashimoto H, Nishioka M, Fujiwara S, Takagi M, Imanaka T, Inoue T, Kai Y, "Crystal structure of DNA polymerase from hyperthermophilic archaeon Pyrococcus kodakaraensis KOD1." J Mol Biol. 306(3), 469-477, 2001. DOI: http://dx.doi.org/10.1006/jmbi.2000.4403   DOI
17 Atsushi Masamune, Shin Hamada, Kazuhiro Kikuta, Tetsuya Takikawa, Shin Miura, Eriko Nakano, Tooru Shimosegawa. "The angiotensin II type I receptor blocker olmesartan inhibits the growth of pancreatic cancer by targeting stellate cell activities in mice" Journal of Gastroenterology. 48, pp. 602-609, 2013. DOI: http://dx.doi.org/10.3109/00365521.2013.777776   DOI
18 Cho S, Kim HH, Lee MJ, Lee S, Park CS, Nam SJ, Han JJ, Kim JW, Chung JH, "Phosphatidylserine prevents UV-induced decrease of type I procollagen and increase of MMP-1 in dermal fibroblasts and human skin in vivo" J Lipid Res. 49, pp. 1235-1245, 2008. DOI: http://dx.doi.org/10.1194/jlr.M700581-JLR200   DOI