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http://dx.doi.org/10.5762/KAIS.2014.15.9.5628

Effect of Artemisia annua Linne callus induced by plant cell culture technology on wound healing  

Oh, Seung Taek (Anti-aging Research Institute of BIO-FD&C Co., Ltd.)
Jung, Hae Soo (Anti-aging Research Institute of BIO-FD&C Co., Ltd.)
Cho, Moon Jin (Anti-aging Research Institute of BIO-FD&C Co., Ltd.)
Song, Mi Young (Anti-aging Research Institute of BIO-FD&C Co., Ltd.)
Moh, Sang Hyun (Anti-aging Research Institute of BIO-FD&C Co., Ltd.)
Seo, Hyo Hyun (Anti-aging Research Institute of BIO-FD&C Co., Ltd.)
Publication Information
Journal of the Korea Academia-Industrial cooperation Society / v.15, no.9, 2014 , pp. 5628-5636 More about this Journal
Abstract
Currently, many countries have an interest in developing cosmetics materials using native plants. In this aspect, there is increasing need to develop cosmetics materials using native plants in our county. In the present study, calluses were induced from Artemisia annua Linne, which was highlighted because of its useful effects, such as anti-cancer, anti-fungal and anti-inflammation. Water and ethanol extractions were performed from the calluses of Artemisia annua Linne. After the mass production of Artemisia annua Linne's calluses, water and ethanol extraction was performed to examine its functional roles in healing wounds and inflammation. The differences in the effective elements were observed in the ethanol extract. The callus showed anti-inflammation activity through the suppression of the inflammation-related gene, COX-2, and ethanol extracts showed their ability to heal wounds. Overall, these results suggest that the extract of Artemisia annua Linne's calluses is a natural and environment-friendly material, and can be used as medical supplies associated with anti-inflammation and healing wounds.
Keywords
Artemisia annua Linne; Anti-inflammation; Plant cell culture technology; Wound healing;
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Times Cited By KSCI : 1  (Citation Analysis)
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1 Kang, B. H. "Native plants and useful plants", Korean J. Seed Sci. 28, 12-16, 2008.
2 Hong Yunho, "Food physiological active substance science", Chonnam National University Press. 13-72, 2009
3 Choi EJ, Kim GH, "Antioxidant and anticancer activity of Artemisia princeps var. orientalis extract in HepG2 and Hep3B hepatocellular carcinoma cells", Chin J Cancer Res. 25, 536-243, 2013.
4 Kim JH, Jung SH, Yang YI, Ahn JH, Cho JG, Lee KT, Baek NI, Choi JH, "Artemisia leaf extract induces apoptosis in human endometriotic cells through regulation of the p38 and NF$\kappa$B pathways", J Ethnopharmacol. 145, 767-775, 2013. DOI: http://dx.doi.org/10.1016/j.jep.2012.12.003   DOI
5 Chang SH, Jung EJ, Park YH, Lim DG, Ko NY, Choi WS, Her E, Kim SH, Choi KD, Bae JH, Kim SH, Kang CD, Han DJ, Kim SC, "Anti-inflammatory effects of Artemisia princeps in antigen-stimulated T cells and regulatory T cells", J Pharm Pharmacol. 61, 1043-1050, 2009. DOI: http://dx.doi.org/10.1211/jpp.61.08.0008   DOI   ScienceOn
6 Kang GJ, Kang NJ, Han SC, Koo DH, Kim YS, Lee JH, Kim SC, Park DH, Lee JS, Kang HK, Yoo ES, "HaCaT 각질형성세포에서 개똥쑥(Artemisia annua L) 유래 성분인 Artemisinic acid의 Macrophage-derived Chemokine 억제효과", Korean J Pharm. 43, 217-223, 2012.
7 Kiharu I, Miho I, Toshimi H. "Major antioxidative substances in leaves of Atsumi-kabu", Agric Biol Chem. 54, 1053-1055, 1990. DOI: http://dx.doi.org/10.1271/bbb1961.54.1053   DOI
8 Hayashi, T., Hayakawa, Y., Hayashi, T., Sasaki, H., Sakuragawa, N., "Sulfated polysaccharide from the leaves of Artemisia princeps activates heparin cofactor II independently of the Lys 173 and Arg 189 residues of heparin cofactor II", Thromb. Res. 87, 105-112, 1997.   DOI   ScienceOn
9 Kim, N.M., Kim, J., Chung, H.Y., Choi, J.S. "Isolation of luteolin 7-O-rutinoside and esculetin with potential antioxidant activity from the aerial parts of Artemisia montana", Arch. Pharm. Res. 23, 237-239, 2000. DOI: http://dx.doi.org/10.1007/BF02976451   과학기술학회마을   DOI
10 Toda, S., Shirataki, Y. "Inhibitory effects of isoflavones in roots of the Astragalus membranaceus Bunge (astragali radix) on lipid peroxidation by reactive oxygen species", Phytother. Res. 12, 59-61, 1998. DOI : http://dx.doi.org/10.1002/(SICI)1099-1573(19980201) 12:1% 3C59::AID-PTR182%3E3.0.CO;2-R   DOI   ScienceOn
11 K. E. Hwang, H. W. Kim, Y. S. Choi, S. Y. Lee, E. J. Yeo, Y. K. Ham, S. M. Choi, M. A. Lee, C. J. Kim, "Evaluation of the antioxidant effect of ganghwayakssuk (Artemisia princeps Pamp.) extract alone and in combination with ascorbic acid in raw chicken patties", Poultry Science, 92, 3244-3250, 2013. DOI: http://dx.doi.org/10.3382/ps.2013-03274   DOI
12 Ryu SY, Kim JO, Choi SU. "Cytotoxic components of Artemisia princeps", Planta Med. 63, 384-385, 1997. DOI: http://dx.doi.org/10.1055/s-2006-957714
13 Sarath VJ, So CS, Won YD, "Artemisia princeps var orientalis induces apoptosis in human breast cancer MCF-7 cells", Anticancer Res. 27, 3891-3898, 2007.
14 Fotakis G, Timbrell JA, "In vitro cytotoxicity assays: comparison of LDH, neutral red, MTT and protein assay in hepatoma cell lines following exposure to cadmium chloride", Toxicol Lett. 160, 171-177, 2006. DOI: http://dx.doi.org/10.1016/j.toxlet.2005.07.001   DOI   ScienceOn
15 Bora KS, Sharma A. "Evaluation of antioxidant and freeradical scavenging potential of Artemisia absinthium", Pharm Biol. 49, 1216-1223, 2011. DOI: http://dx.doi.org/10.3109/13880209.2011.578142   DOI
16 Kim KS, Lee S, Lee YS, "Anti-oxidant activities of the extracts from the herbs of Artemisia apiacea", J Ethnopharmacol. 85, 69-72, 2003. DOI: http://dx.doi.org/10.1016/S0378-8741(02)00338-0   DOI   ScienceOn
17 Van Meerloo J, Kaspers GJ, Cloos J, "Cell sensitivity assays: the MTT assay", Methods Mol Biol. 731, 237-245, 2011. DOI: http://dx.doi.org/10.1007/978-1-61779-080-5_20   DOI   ScienceOn
18 E. M. Middleton, A. H. Teramura, "The role of flavonol glycosides and carotenoids in protecting soybean from ultraviolet-B damage", Plant Physiol. 103, 741-752, 1993.
19 Saveria Pastore, Daniela Lulli, Alla I. Potapovich, Paolo Fidanza, Vladimir A. Kostyuk, Elena Dellambra, Chiara De Luca, Riccardo Maurelli, Liudmila G. Korkina, "Differential modulation of stress-inflammation responses by plant polyphenols in cultured normal human keratinocytes and immortalized HaCaT cells", J Dermatological Science, 63, 104-114, 2011.
20 Potapovich AI, Lulli D, Fidanza P, Kostyuk VA, De Luca C, Pastore S, Korkina LG, "Plant polyphenols differentially modulate inflammatory responses of human keratinocytes by interfering with activation of transcription factors NF$\kappa$B and AhR and EGFR-ERK pathway", Toxicol Appl Pharmacol. 255, 138-149, 2011. DOI: http://dx.doi.org/10.1016/j.taap.2011.06.007   DOI   ScienceOn
21 Coomber BL, Gotlieb AI, "In vitro endothelial wound repair, interaction of cell migration and proliferation", Arteriosclerosis. 10, 215-222, 1990. DOI: http://dx.doi.org/10.1161/01.ATV.10.2.215   DOI
22 Atsushi Masamune, Shin Hamada, Kazuhiro Kikuta, Tetsuya Takikawa, Shin Miura, Eriko Nakano, Tooru Shimosegawa, "The angiotensin II type I receptor blocker olmesartan inhibits the growth of pancreatic cancer by targeting stellate cell activities in mice", Journal of Gastroenterology. 48, 602-609, 2013.
23 Cho S, Kim HH, Lee MJ, Lee S, Park CS, Nam SJ, Han JJ, Kim JW, Chung JH, "Phosphatidylserine prevents UV-induced decrease of type I procollagen and increase of MMP-1 in dermal fibroblasts and human skin in vivo", J Lipid Res. 49, 1235-1245, 2008. DOI: http://dx.doi.org/10.1194/jlr.M700581-JLR200   DOI   ScienceOn
24 Justin C Yarrow, Zachary E Perlman, Nicholas J Westwood, Timothy J Mitchison, "A high-throughput cell migration assay using scratch wound healing, a comparison of image-based readout methods", BMC Biotechnology. 4, 21, 2004. DOI: http://dx.doi.org/10.1186/1472-6750-4-21   DOI
25 Lampugnani MG, "Cell migration into a wounded area in vitro", Methods Mol Biol. 96, 177-182, 1999.
26 Kaji T, Kaga K, Miezi N, Hayashi T, Ejiri N, Sakuragawa N, "Possible mechanism of the stimulatory effect of Artemisia leaf extract on the proliferation of cultured endothelial cells: involvement of basic fibroblast growth factor", Chem Pharm Bull (Tokyo). 38, 2494-2497, 1990. DOI: http://dx.doi.org/10.1248/cpb.38.538   DOI