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http://dx.doi.org/10.5762/KAIS.2014.15.9.5594

Role of Samultang in Formalin-induced Orofacial pain  

Kim, Yun-Kyung (Depart. of Biomedical Health Science, Dong-eui University)
Hyun, Kyung-Yae (Depart. of Biomedical Health Science, Dong-eui University)
Park, Min-Kyoung (Depart. of Dental Hygiene, Kyung-woon University)
Lee, Min-Kyung (Depart. of Biomedical Health Science, Dong-eui University)
Publication Information
Journal of the Korea Academia-Industrial cooperation Society / v.15, no.9, 2014 , pp. 5594-5601 More about this Journal
Abstract
The aim of this study was to evaluate the analgesic effects of Samultang by measuring the anti-inflammatory and antioxidative activities in formalin-induced orofacial pain. The anti-inflammatory and anti-oxidative effects were measured by western blot analysis for p38 MAPK(Mitogen-activated protein kinases), iNOS(induceble nitric oxide synthase) and NOX4(nicotinamide adenine dinucleotide phosphate4) in a rat's brain and medulla oblongata. Samultang significantly attenuated the increased formalin-induced nociceptive response and inhibited the p38 MAPK and iNOS that led to inflammatory pain. In addition, this study indicated that Samultang possess antioxidative effects through the blockade of NOX4. These findings suggest that Samultang plays an important role in the peripheral processing of inflammatory pain in the orofacial area.
Keywords
iNOS; NOX4; Orofacial pain; p38 MAPK; Samultang;
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