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http://dx.doi.org/10.5762/KAIS.2012.13.12.5860

A study on proper number of stimulations in functional MRI  

Son, Soon-Yong (Department of Health Science, Graduate School Hanyang University)
Kim, Yoon-Shin (Department of Health Science, Graduate School Hanyang University)
Choi, Kwan-Woo (Department of Radiology, Asan Medical Center)
Min, Jung-Whan (Department of Radiology, Shin-Gu University)
Lee, Jong-Seok (Department of Radiotechnology, Wonkwang Health Science University)
Yoo, Beong-Gyu (Department of Radiotechnology, Wonkwang Health Science University)
Publication Information
Journal of the Korea Academia-Industrial cooperation Society / v.13, no.12, 2012 , pp. 5860-5866 More about this Journal
Abstract
BOLD technique in functional MRI has to apply multiple stimulations. However as the stimulation time increases failure rates rise. In this study we are proposing proper number of stimulations through our experiments. Ten normal people underwent functional MRI hand motor sanning and the paradigms were designed from first to seventh stimulation. Under Philips Intera Achieva 3.0T MR system and Invivo cop's Eloquence equipment, activation periods and rest periods were repeated ten times each, using BOLD EPI technique. Primary hand motor area stimulation and number of clusters, activation rates and number of activated clusters in and outside the region of interest were compared to each other. Number of clusters in region of interest was lower than others at second stimulation and became static from third stimulation. The stimulated ratios were elevated as the number of stimulations were increased but it was not proportional. Number of clusters outside the ROI became static from the third stimulation and started increasing from sixth stimulation. As results, given the activation ratios of ROI and out side the ROI, three times stimulation was the most appropriate because it does not affect accuracy, also decreasing the fatigue of patients by with the decreased scanning time.
Keywords
fMRI; BOLD; Number of stimulations; Activated ratio;
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