Browse > Article
http://dx.doi.org/10.5762/KAIS.2011.12.11.5012

The resistance rate of anti-tuberculosis drug isolated from initial tuberculosis patients at a general hospital in Daejeon area  

Lee, Dong-Hoon (Dept. of Public Health and Welfare Graduate school of Konyang University)
Kim, Sang-Ha (Dept. of Laboratory Medicine of Sangju Hospital, The Republic of National Red Cross)
Kim, Young-Kwon (Dept. of Biomedical Laboratory Science of Konyang University)
Publication Information
Journal of the Korea Academia-Industrial cooperation Society / v.12, no.11, 2011 , pp. 5012-5018 More about this Journal
Abstract
According to the nationwide survey of tuberculosis from 1965 to 1995, the incidence and drug resistance rate of tuberculosis have been decreased in Korea, but the prevalence of multidrug resistance of Mycobacterium tuberculosis is still a serious problem. The purpose of this study is to investigate the drug resistance rate and pattern of tuberculosis in Daejeon from 2001 to 2008. Of the total 581cases where the drug susceptibility test was performed, resistance to at least one anti-TB drug was found in 104 cases(17.9%) of these, 68(11.7%) were resistant to at least INH and 41(7.1%) were resistant to at least RFP. Single-drug resistance was found for isolates from 37(6.4%) ; 18(3.1%) of these were resistant to INH and 5(0.9%) to RFP. Multidrug resistance, where TB was resistant to at least isoniazid and refampin, was found in 35 cases(6.0%). and Factors associated with MDR-TB included age under 40-60.The drug-resistance rate of pulmonary TB, especially MDR-TB, is higher in the initial treated patients at a private referral hospital than in those in the pubulic sector. Initial drug resistance is common and the drug susceptibility test is informative for pulmonary TB patients who have not received previous TB treatment. The need for an improved control program, coupled with early diagnosis of MDR-TB, to reduce the spread and development of resistance. Multidrug resistance rate is still problem in korea. Efforts to decrease multidrug resistance rate either independently or in cooperation with the pubulic sector will be needed.
Keywords
Multi-drug resistance tuberculosis; Ziehl-Neelsen method; Ogawa medium;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Sonchunhui, yangdugyeong, nomisuk, jeongjinsuk, yihyeok, yiginam. Part sanjiyeok tuberculosis patients admitted to a tertiary hospital in the association between predictors and drug naeseongryul, Tuberculosis and Lake Intake diseases 2001; 51:416-25.
2 Choi JC, Lim SY, Suh GY, Chung MP, Kim H, Kwon OJ,et al, Drug resistance rates of Mycob acterium tubercuolosis at a private referral cent er in korea, Korean Med Sci 2007;22:677-81.   DOI
3 Koziel H, Koziel MJ. Pulmonary complications of diabetes mellitus. Infect Dis Clin North Am 1995;9:65-96.
4 Bashar M. Alcabes P, Rom WN, Condos R. Inc reased incidence of multidrug resistant tubercu losis in diabetic patient on the Bellevue Chest Service, 1987-1997. Chest 2001;120:1514-9.   DOI
5 Gimdogyun, gimmiok, gimtaehyeong, sonjangwon, yunhoju, sindongho. Surveyed in auniversity hospital in Seoul naeseongryul and risk factors for tuberculosis drugs. Tuberculosis and Respiratory Diseases 2005; 58:243-7.   DOI
6 Pao CC, Lin SS, Wu SY, Juang WM: The detec tion of mycobacteria DNA sequences in uncultured clinical specimens with cloned Mycobacterium tuberculosis DNA as probes.Tubercle 69:2.1988.
7 Bai GH, Anti-tuberculosis drug resistance in kor ea. CDMR 2005;16:101-7.
8 Dye C, Espinal MA, Watt CJ, Mbiaga C, Willia ms BG, Worldwide incidence of multidrug-re sistant tuberculosis. J Infect Dis 2002;185:1197-2 02.   DOI
9 Jangcheolhun, yieunyeop, baksungyu, jeongseokhun. 1981-2004 rate of resistant tuberculosis public health trend of re-treatment tuberculosis patients. Tuberculosis and Respiratory Diseases 2005; 59:619-624.   DOI
10 Ryuwoojin. Surveillance of tuberculosis in South Korea. Tuberculosis and Respiratory Diseases 2000; 48:298-307.   DOI
11 World Health Organization Treatment of tubercul osis : guidelines for National programmes. 3rd, Geneva, Switzerland : WHO;2003.
12 Jung YJ, Park IN, Hong SB, Oh YM, LIm CM, Lee SD, et al. The clinical characters,diagnosis, treatment, and outcomes of patients with tube rculosis at a private university hospital in korea. Tuberc Respir Dis 2006;60:194- 204.   DOI
13 Korean Academy of Tuberculosis and Respiratory Disease. Guideline for the management of pulmonary tuberculosis. Seoul :korea Academy of Tuberculosis and Respiratory Diseases; 2005.
14 Bakyounggil, bakyunseong, baejeongim, gimhuijin, ryuwoojin 0.2003 to 2005, including private hospitals and clinics year Renewal of Mycobacterium tuberculosis isolated from tuberculosis naeseongryul party. Tuberculosis and Respiratory Diseases 2008; 6 4:87-94.   DOI
15 Jeongyoungju, bakyinae, hongsangbeom, ohyeonmok, imchaeman etc. TB patients in a private hospital in Korea's medical siltae. RESULTS nucleus and respiratory diseases 2006; 60:194-204.
16 Espinal MA, Laszlo A, Simonsen L, Boulahbal F, Kim SJ, Reniero A, et al. Global trends in resist ance to antituberculosis Health Organization-Inte rnational Union against Tuberculosis and Lung Disease Working Group on Anti-Tuberculosis dr ug Resistance Surveillance. N engl J M ed 2001 ;344:1294-303.   DOI
17 Department of Health and Human Services, Tuberculosis Association: Seventh National Tuberculosis Survey, 1995.
18 Hongyoungpyo. Tuberculosis in Korea yesterday, today, tomorrow. Tuberculosis and Respiratory Diseases 1997; 44:1-10.   DOI