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http://dx.doi.org/10.5762/KAIS.2010.11.9.3358

Extracts of Sorbus commixta and Geranium thunbergii inhibit Osteoclastogenesis and stimulate Chondrogenesis  

Moon, Eun-Jung (Graduate School of East-West Medical Science, Kyung Hee University Global Campus)
Youn, You-Suk (Department of Oriental Rehabilitation Medicine, Neck and Back Oriental Medicine Hospital)
Choi, Bo-Yun (Department of Dental Pharmacology, School of Dentistry, Chonbuk National University)
Jeong, Hyun-Uk (East-West Pharmaceutical Research Institute, Kyung Hee University)
Park, Ji-Ho (Graduate School of East-West Medical Science, Kyung Hee University Global Campus)
Oh, Myung-Sook (East-West Pharmaceutical Research Institute, Kyung Hee University)
Soh, Yun-Jo (Department of Dental Pharmacology, School of Dentistry, Chonbuk National University)
Kim, Sun-Yeou (Graduate School of East-West Medical Science, Kyung Hee University Global Campus)
Publication Information
Journal of the Korea Academia-Industrial cooperation Society / v.11, no.9, 2010 , pp. 3358-3365 More about this Journal
Abstract
This study was carried out to investigate the effect of Sorbus commixta (SC), Geranium thunbergii (GT) and their mixture (SC:GT=1:1, MIX) on inhibition of bone loss and chondral defect. To examine their activities, we measured the alkaline phosphatase (ALP) activity in human osteoblast-like MG-63 cells and performed tartrate-resistant acid phosphate (TRAP) staining in osteoclast differentiated from Raw264.7 cells. To investigate the influence on chondrocyte differentiation, we performed alcian-blue staining in chondrocyte differentiated from ATDC5 cells. All of SC, GT and MIX did not increase ALP activity in MG-63 cells. However, SC and mixture (SC:GT=1:1, MIX) significantly inhibited osteoclastic differentiation. And they also induced chondrocyte differentiation. These results suggest that SC and GT may have a potential for the treatment of bone loss and chondral defect by suppression of osteoclast differentiation and stimulation of chondrocyte differentiation. Therefore, clarification of their mechanisms and active components will be needed.
Keywords
Osteoblast; Osteoclast; Chondrocyte; Sorbus commixta; Geranium thunbergii;
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