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http://dx.doi.org/10.5625/lar.2014.30.3.112

13-week subchronic toxicity study of a novel ginsenoside composition from ginseng leaves in rats  

Shin, Won-Ho (Department of Histology, College of Veterinary Medicine, Kyungpook National University)
Ri, Yu (Department of Histology, College of Veterinary Medicine, Kyungpook National University)
Do, Seon-Gil (Unigen Inc.)
Lee, Young-Chul (Unigen Inc.)
Park, Sang-Joon (Department of Histology, College of Veterinary Medicine, Kyungpook National University)
Publication Information
Laboraroty Animal Research / v.30, no.3, 2014 , pp. 112-122 More about this Journal
Abstract
UG0712 is a new ginsenoside extract processed from ginseng leaves. A subchronic toxicity study of UG0712 was conducted in male and female SD rats. Rats were treated with UG0712 at doses of 100, 400 and 1,600 mg/kg/day for 13 weeks, and observed followed by 4-week recovery period at a highest dose. No-treatment-related effects were observed regarding the mortality, ophthalmic examination, urinalysis and histopathology. Although the changes in clinical sign, body weight, organ weight, hematology, and serum biochemistry were observed, they were temporal and pharmacological effects. Based on the present experiment conditions, the no observed adverse effect level was considered to be more than 1,600 mg/kg/day in both sexes of rats.
Keywords
UG0712; ginsenoside extract; ginseng leaf; subchronic toxicity; SD rats;
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1 Kim DH, Chung JH, Yoon JS, Ha YM, Bae S, Lee EK, Jung KJ, Kim MS, Kim YJ, Kim MK, Chung HY. Ginsenoside Rd inhibits the expressions of iNOS and COX-2 by suppressing NF-eB in LPS-stimulated RAW264.7 cells and mouse liver. J Ginseng Res 2013; 37(1): 54-63.   DOI
2 Yun TK. Brief introduction of Panax ginseng C.A. Meyer. J Korean Med Sci 2001; 16 Supp l: S3-5.   DOI
3 Kiefer D, Pantuso T. Panax ginseng. Am Fam Physician 2003; 68(8): 1539-1542.
4 Leung KW, Wong AS. Pharmacology of ginsenosides: a literature review. Chin Med 2010; 5: 20.   DOI   ScienceOn
5 Kim HS, Lee EH, Ko SR, Choi KJ, Park JH, Im DS. Effects of ginsenosides Rg3 and Rh2 on the proliferation of prostate cancer cells. Arch Pharm Res 2004; 27(4): 429-435.   DOI
6 Hu G, Wu Z, Yang F, Zhao H, Liu X, Deng Y, Shi M, Zhao G. Ginsenoside Rd blocks AIF mitochondrio-nuclear translocation and NF-eB nuclear accumulation by inhibiting poly(ADP-ribose) polymerase-1 after focal cerebral ischemia in rats. Neurol Sci 2013; 34(12): 2101-2106.   DOI
7 Tian J, Fu F, Geng M, Jiang Y, Yang J, Jiang W, Wang C, Liu K. Neuroprotective effect of 20(S)-ginsenoside Rg3 on cerebral ischemia in rats. Neurosci Lett 2005; 374(2): 92-97.   DOI   ScienceOn
8 Tian J, Zhang S, Li G, Liu Z, Xu B. 20(S)-ginsenoside Rg3, a neuroprotective agent, inhibits mitochondrial permeability transition pores in rat brain. Phytother Res 2009; 23(4): 486-491.   DOI   ScienceOn
9 Liu JP, Lu D, Nicholson RC, Zhao WJ, Li PY, Wang F. Toxicity of a novel anti-tumor agent 20(S)-ginsenoside Rg3: a 26-week intramuscular repeated administration study in rats. Food Chem Toxicol 2012; 50(10): 3388-3396.   DOI   ScienceOn
10 Chai H, Do S, Kim J, Kim D, Sung S, Lee Y, Woo S, Kang J. UG0712, a novel ginsenoside composition enhances the endurance exercise capacity and fatigue recovery. Lab Anim Res 2009; 25: 207-212.
11 Chan PC, Peckham JC, Malarkey DE, Kissling GE, Travlos GS, Fu PP. Two-year toxicity and carcinogenicity studies of Panax ginseng in Fischer 344 rats and B6C3F1 mice. Am J Chin Med 2011; 39(4): 779-788.   DOI
12 Liu JP, Lu D, Nicholson RC, Li PY, Wang F. Toxicity of a novel anti-tumor agent 20(S)-ginsenoside Rg3: a 26-week intramuscular repeated administration study in Beagle dogs. Food Chem Toxicol 2011; 49(8): 1718-1727.   DOI   ScienceOn
13 Lu D, Liu J, Zhao W, Li P. Chronic toxicity of ginsenoside Re on Sprague-Dawley rats. J Ethnopharmacol 2012; 144(3): 656-663.   DOI
14 Wan JB, Yang FQ, Li SP, Wang YT, Cui XM. Chemical characteristics for different parts of Panax notoginseng using pressurized liquid extraction and HPLC-ELSD. J Pharm Biomed Anal 2006; 41(5): 1596-1601.   DOI   ScienceOn
15 Wang CZ, Wu JA, McEntee E, Yuan CS. Saponins composition in American ginseng leaf and berry assayed by high-performance liquid chromatography. J Agric Food Chem 2006; 54(6): 2261-2266.   DOI   ScienceOn
16 Gu Y, Wang GJ, Sun JG, Jia YW, Wang W, Xu MJ, Lv T, Zheng YT, Sai Y. Pharmacokinetic characterization of ginsenoside Rh2, an anticancer nutrient from ginseng, in rats and dogs. Food Chem Toxicol 2009; 47(9): 2257-2268.   DOI   ScienceOn
17 Kim U, Park MH, Kim DH, Yoo HH. Metabolite profiling of ginsenoside Re in rat urine and faeces after oral administration. Food Chem 2013; 136(3-4): 1364-1369.   DOI
18 Aphale AA, Chhibba AD, Kumbhakarna NR, Mateenuddin M, Dahat SH. Subacute toxicity study of the combination of ginseng (Panax ginseng) and ashwagandha (Withania somnifera) in rats: a safety assessment. Indian J Physiol Pharmacol 1998; 42(2): 299-302.
19 Yang KS, Kim YK, B PS. Studies on the anion contents in crude drugs. Kor. J. Pharmacogn 1989; 20(1), 64.
20 Kwon YS, Jang KH. The effect of Korean red ginseng on liver regeneration after 70% hepatectomy in rats. J Vet Med Sci 2004; 66(2): 193-195.   DOI   ScienceOn
21 Kwon YS, Jang KH, Jang IH. The effects of Korean red ginseng (ginseng radix rubra) on liver regeneration after partial hepatectomy in dogs. J Vet Sci 2003; 4(1): 83-91.