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Anti-inflammatory Activities of a Herbal Preparation (HemoHI$M^{\circledR})$  

Lee, Hae-June (College of Veterinary Medicine, Chonnam National University)
Kim, Se-Ra (College of Veterinary Medicine, Chonnam National University)
Kim, Jong-Choon (College of Veterinary Medicine, Chonnam National University)
Bae, Chun-Sik (College of Veterinary Medicine, Chonnam National University)
Jo, Sung-Kee (Food Irradiation Team, Korea Atomic Energy Research)
Jung, U-Hee (Food Irradiation Team, Korea Atomic Energy Research)
Park, Hae-Ran (Food Irradiation Team, Korea Atomic Energy Research)
Kim, Sung-Ho (College of Veterinary Medicine, Chonnam National University)
Publication Information
Laboraroty Animal Research / v.21, no.3, 2005 , pp. 267-271 More about this Journal
Abstract
These studies were conducted to investigate the antiinflammatory effects of a herbal preparation (HemoHI$M^{\circledR})$). We used the methods of 'carrageenan induced foot edema', 'inhibition test of vascular permeability', 'inhibition test of white blood cell migration' and 'formation of granuloma' to examine the antiinflammatory effects of HemoHI$M^{\circledR})$. The oral administration (4 mg of solids/ml of drinking water) or intraperitoneal injection (50 mg/kg of body weight or 200 mg/kg of body weight) of HemoHI$M^{\circledR})$ showed antiinflammatory effect on carrageenan induced foot edema, inhibition test of vascular permeability, inhibition test of white blood cell migration and formation of granuloma. These results demonstrate a herbal preparation (HemoHI$M^{\circledR})$) possesses potent antiinflammatory effect.
Keywords
HemoHI$M^{\circledR})$; antiinflammatory effect;
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1 Park, H.R., Kim, S.H., Yee, S.T., Byun, M.W. and Jo, S.K. (2005) The effects of a herb mixture (HIM-1) on the protection of the hematopoietic-immune system and selfrenewal tissues against radiation damage. J. Korean Soc. Food Sci. Nutr. 34, 605-612   DOI
2 Cho, C.H., Mei, Q.B., Shang, P., Lee, S.S., So, H.L., Guo, X. and Li, Y. (2000) Study of the gastrointestinal protective effects of polysaccharides from Angelica sinensis in rats. Planta Med. 66, 348-351   DOI   ScienceOn
3 Dai, Y., But, P.P., Chan, Y.P., Matsuda, H. and Kubo, M. (2002) Antipruritic and antiinflammatory effects of aqueous extract from Si-Wu-Tang. Biol. Pharm. Bull. 25, 1175-1178   DOI   ScienceOn
4 Kim, S.H., An, M.R., Nah, S.Y., Lee, J.H., Kim, J.H., Jo, S.K., Jang, S.J. and Shin, D.H. (2001a) The effects of herbs on the radiationinduced apoptosis in intestinal crypt cells. J. Korea Assoc. Radiat. Prot. 26, 27-33
5 Oh, H., Park, H.R., Jeong, I.Y., Kim, S.H. and Jo, S.K. (2002) Protective effects of Paeonia japonica against radiation-induced damage. J. Korea Assoc. Radiat. Prot. 27, 181-188
6 Winter, C.A., Risley, E.A. and Nuss, G.W. (1962) Carrageenin-induced edema in hind paw of the rat as an assay for antiiflammatory drugs. Proc. Soc. Exp. Biol. Med. 111, 544-547
7 Doherty, N.S., Poubelle, P., Borgeat, P., Beaver, T.H., Westrich, G.L. and Schrader, N.L. (1985) Intraperitoneal injection of zymosan in mice induces pain, inflammation and the synthesis of peptidoleukotrienes and prostaglandin E2. Prostaglandins 30, 769-789   DOI   ScienceOn
8 Jo, S.K., Park, H.R., Jung, U., Oh, H., Kim, S.H. and Vee, S.T. (2005) Protective effects of a herb preparation (HemoHIM') on the self-renewal tissues and immune system against r-irradiation. J. Korean Soc. Food Sci. Nutr. 34, 805-813   DOI
9 Choi, Y.E., Ahn, H. and Ryu, J.H. (2000) Polyacetylenes from angelica gigas and their inhibitory activity on nitric oxide synthesis in activated macrophages. Biol. Pharm. Bull. 23, 884-886   DOI   ScienceOn
10 Lee, S.E., Oh, H., Yang, J.A., Jo, S.K., Byun, M.W., Yee, S.T. and Kim, S.H. (1999) Radioprotective effects of two traditional Chinese medicine prescriptions: Si-Wu-Tang and Si-Jun-Zi-Tang. Am. J. Chin. Med. 27, 387-396   DOI   ScienceOn
11 Kim, S.H., Lee, S.E., Oh, H., Yang, J.A., Chung, C.Y., Jang, J.S., Yu, Y.B. and Jo, S.K. (1999) The radioprotective effect of Kuei-Pi- Tang as a prescription of traditional Chinese medicine in mice. J. Korean Soc. Food Sci. Nutr. 28, 698-704
12 Salvemini, D., Wang, Z.Q., Wyatt, P.S., Bourdon, D.M., Marino, M.H., Manning, P.T. and Currie, M.G (1996) Nitric oxide: a key mediator in the early and late phase of carrageenan-induced rat paw inflammation. Br. J. Pharmacol. 118, 829-838   DOI   ScienceOn
13 Saito, H. and Nomura, Y. (1990) Screening methods for drug evaluation 3. pp. 45-82, Hirokawa Publishing Company, Tokyo
14 Kim, S.H., Oh, H., Lee, S.E., Jo, S.K. and Byun, M.W. (1998) Effect of Si-Wu-Tang and Si-Jun-Zi-Tang on the survival of jejunal crypt cells and hematopoietic cells in irradiated mice. Korean J. Food Sci. Technol. 30, 888-894
15 Jo, S.K., Yu, Y.B., Oh, H., Kim, S.R. and Kim, S.H. (2000) The effects of Shi-Quan-Dai-Bu-Tang and its ingredients on the survival of jejunal crypt cells and hematopoietic cells in irradiated mice. J. Korean Soc. Food Sci. Nutr. 29, 93-98
16 Kim, S.H., Lee, S.E., Oh, H., Kim, S.R., Yee, S.T., Yu, Y.B., Byun, M.W. and Jo, S.K. (2002) The radioprotective effects of Bu-Zhong- Yi-Qi-Tang: A prescription of traditional Chinese medicine. Am. J. Chin. Med. 30, 127-137   DOI   ScienceOn
17 Whittle, B.A. (1964) The use of changes in capillary permeability in mice to distinguish between narcotic and nonnarcotic alalgesics. Br. J. Pharmacol. 22, 246-253
18 Robbins, S.L., Kumar, V. and Cotran, R.S. (1994) Pathologic basis of disease, 5th ed., pp. 51-92, Saunders Company, Pennsylvania
19 Kim, S.H., Oh, H., Kim, S.R., Jo, S.K., Byun, M.W., Kim, K.S., Lee, J.H. and Shin, D.H. (2001b) The radioprotective effects of radices herbs. Korea J. Vet. Res. 41, 105-111
20 Lu, Z.M., Yu, Y.R., Tang, H. and Zhang, X.X. (2005) The protective effects of radix astragali and rhizoma ligustici chuanxiong on endothelial dysfunction in type 2 diabetic patients with microalbuminuria. Sichuan Da Xue Xue Baa Yi Xue Ban 36, 529-532
21 Raza, M., Dhariwal, M.A., Ageel, A.M. and Qureshi, S. (1996) Evaluation of the antiinflammatory activity of sodium valproate in rats and mice. Gen. Pharmacol. 27, 1395-1400   DOI   ScienceOn