Four-Week Repeated Dose Toxicity Study of a Novel HepatitisB Virus-Immunotherapeutic Agent, MBRI-98304,in Rats and Beagle Dogs |
Hwang, Jae-Sik
(충북대학교)
Jang, Ho-Song (충북대학교) Sin, Ji-Sun (충북대학교) Jeong, Eun-Yong (충북대학교) Gang, Min-Jeong (충북대학교) Gwon, Yeong-Bang (충북대학교) Kim, Yun-Bae (충북대학교) Gang, Jong-Gu (충북대학교) |
1 | Hsu HM, Lu CF, Lee SC, Lin SR & Chen DS (1999): Seroepidemiologic survey for hepatitis B virus infection in Taiwan: the effect of hepatitis B mass immunization. J. Infect. Dis. 179: 360-367 DOI ScienceOn |
2 | Chang JS, Choi MJ, Cheong HS & Kim K (2001): Development of Thl-mediated CD8+ effector T cells by vaccination with epitope peptides encapsulated in pH-sensitive liposomes. Vaccine. 19(27): 3608-3614 DOI ScienceOn |
3 | Vitiello A, Ishioka G, Grey HM, Rose R, Farness P, Lafond R, Yuan L, Chisari FV, Furze J & Bartholomeuz R (1995): Development of a lipopeptide-based therapeutic vaccine to treat chronic HBV infection. I. Induction of a primary cytotoxic T lymphocyte response in humans. J. Clin. Invest. 95(1): 341-349 DOI ScienceOn |
4 | Yale CE & Balish E (1976): Blood and serum chemistry values of gnotobiotic Beagles. Lab. Anim. Sci. 26: 633-639 |
5 | 內山智晴, 常井和男, 出來俊昭 (1985): 實驗用ビ-グル犬の成長に伴 う血液學的ならぴ血淸生化學的性狀の變化. 實驗動物. 34: 367-377 |
6 | Earl FL, Melveger BE & Wilson RL (1973): The hemogram & bone marrow profile of normal neonate & weanling dogs. Lab. Anim. Sci. 23: 690-695 |
7 | Edmunds WJ, Medley GF, Nokes DJ, Hall AJ & Whittle HC (1993): The influence of age on the development of the hepatitis B carrier state. Proc. R Soc. Lond B Biol. Sci. 253: 197-201 DOI ScienceOn |
8 | Marques AR & Straus SE (1998): Advances in the treatment of chronic hepatitis B virus infection. Rev. Med. Virol. 8: 223-234 DOI ScienceOn |
9 | Wolford ST, Schroer RA, Gohs FX, Gallo PP, Brodeck M, Falk HB & Ruhren R (1986): Reference range data base for serum chemistry and hematology values in laboratory animals. J. Toxicol. Environm. Health. 18: 161-168 DOI ScienceOn |
10 | Byars NE, Nakano G, Welch M, Lehman D & Allison AC (1991): Improvement of hepatitis B vaccine by the use of a new adjuvant. Vaccine. 9(5): 309-318 DOI ScienceOn |
11 | Hercas-Stubbs S, Berasain C, Golvano JJ, Lasarte JJ, Prieto I, Sarobe P, Prieto J & Borras-Cuesta F (1994): Overcoming class II-linked non-responsiveness to hepatitis B vaccine. Vaccine 12(10): 867-871 DOI ScienceOn |