[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.30773/pi.2018.11.01

Gray Matter Volume Reductions Were Associated with TPH1 Polymorphisms in Depressive Disorder Patients with Suicidal Attempts

Lee, Sang Min (Department of Psychiatry, School of Medicine, Kyung Hee University)
Lee, Soyoen (Department of Medicine, Graduate School, Kyung Hee University)
Kang, Won Sub (Department of Psychiatry, School of Medicine, Kyung Hee University)
Jahng, Geon-Ho (Department of Radiology, Kyung Hee University Hospital at Gangdong, College of Medicine, Kyung Hee University)
Park, Hae Jeong (Department of Pharmacology, School of Medicine, Kyung Hee University)
Kim, Su Kang (Department of Biomedical Laboratory Science, Catholic Kwandong University)
Park, Jin Kyung (Department of Psychiatry, School of Medicine, Kyung Hee University)

Publication Information

Psychiatry investigation / v.15, no.12, 2018 , pp. 1174-1180 More about this Journal

Abstract

Objective Structural changes of brain areas have been reported in depressive disorder and suicidal behavior (SB), in which TPH1 also has been known as a promising candidate gene. We investigated gray matter volume (GMV) differences, TPH1 rs1800532 and rs1799913 polymorphisms previously found to be associated with depressive disorder and SB, and the relationship between the two markers. Methods Thirteen depressive disorder patients with suicidal attempts (SA) and twenty healthy controls were included. We examined GMV differences using a voxel-based morphometry and regions of interest analysis. Direct sequencing was used for genotyping. Results The patients showed significant GMV reduction in left cerebral region including middle frontal gyrus, inferior frontal gyrus, and anterior cingulate cortex; in right middle temporal gyrus; in left cerebellar tonsil; and in right cerebral region including precentral gyrus and postcentral gyrus (corrected p<0.005). The right precentral and postcentral gyri GMV values of AA and CA genotypes patients were significantly decreased compared to those of CC genotype subjects (corrected p=0.040). Conclusion These findings show the possibility that both GMV reductions and TPH1 rs1800532/rs1799913 A allele may be involved in the pathogenesis of depressive disorder patients with SA.

Keywords

Depressive disorder; Suicidal attempt; Gray matter volume; TPH1 gene;

Citations & Related Records

Reference

1	Mann JJ, Arango VA, Avenevoli S, Brent DA, Champagne FA, Clayton P, et al. Candidate endophenotypes for genetic studies of suicidal behavior. Biol Psychiatry 2009;65:556-563. DOI
2	Caceda R, Durand D, Cortes E, Prendes-Alvarez S, Moskovciak T, Harvey PD, et al. Impulsive choice and psychological pain in acutely suicidal depressed patients. Psychosom Med 2014;76:445-451. DOI
3	Corruble E, Damy C, Guelfi JD. Impulsivity: a relevant dimension in depression regarding suicide attempts? J Affect Disord 1999;53:211-215. DOI
4	Moreno-Rius J, Miquel M. The cerebellum in drug craving. Drug Alcohol Depend 2017;173:151-158. DOI
5	Peng D, Shi F, Li G, Fralick D, Shen T, Qiu M, et al. Surface vulnerability of cerebral cortex to major depressive disorder. PLoS One 2015;10:e0120704. DOI
6	Bos MGN, Peters S, van de Kamp FC, Crone EA, Tamnes CK. Emerging depression in adolescence coincides with accelerated frontal cortical thinning. J Child Psychol Psychiatry 2018;59:994-1002. DOI
7	Tsujii N, Mikawa W, Tsujimoto E, Adachi T, Niwa A, Ono H, et al. Reduced left precentral regional responses in patients with major depressive disorder and history of suicide attempts. PLoS One 2017;12:e0175249. DOI
8	Minzenberg MJ, Lesh TA, Niendam TA, Yoon JH, Cheng Y, Rhoades RN, et al. Control-related frontal-striatal function is associated with past suicidal ideation and behavior in patients with recent-onset psychotic major mood disorders. J Affect Disord 2015;188:202-209. DOI
9	Bush G, Whalen PJ, Rosen BR, Jenike MA, McInerney SC, Rauch SL. The counting Stroop: an interference task specialized for functional neuroimaging--validation study with functional MRI. Hum Brain Mapp 1998;6:270-282. DOI
10	Carter CS, Mintun M, Nichols T, Cohen JD. Anterior cingulate gyrus dysfunction and selective attention deficits in schizophrenia: [15O] H2O PET study during single-trial Stroop task performance. Am J Psychiatry 1997;154:1670-1675. DOI
11	Mann JJ. Neurobiology of suicidal behaviour. Nat Rev Neurosci 2003;4:819-828.
12	Mirkovic B, Laurent C, Podlipski MA, Frebourg T, Cohen D, Gerardin P. Genetic association studies of suicidal behavior: a review of the past 10 years, progress, limitations, and future directions. Front Psychiatry 2016;7:158.
13	World Health Organization. Depression and Other Common Mental Disorders: Global Health Estimates. Geneva: World Health Organization; 2017.
14	Zhang FF, Peng W, Sweeney JA, Jia ZY, Gong QY. Brain structure alterations in depression: psychoradiological evidence. CNS Neurosci Ther 2018;24:994-1003. DOI
15	van Eijndhoven P, van Wingen G, Katzenbauer M, Groen W, Tepest R, Fernandez G, et al. Paralimbic cortical thickness in first-episode depression: evidence for trait-related differences in mood regulation. Am J Psychiatry 2013;170:1477-1486. DOI
16	Jia Z, Wang Y, Huang X, Kuang W, Wu Q, Lui S, et al. Impaired frontothalamic circuitry in suicidal patients with depression revealed by diffusion tensor imaging at 3.0 T. J Psychiatry Neurosci 2014;39:170-177. DOI
17	Peng W, Chen Z, Yin L, Jia Z, Gong Q. Essential brain structural alterations in major depressive disorder: a voxel-wise meta-analysis on first episode, medication-naive patients. J Affect Disord 2016;199:114-123. DOI
18	Lee BH, Kim YK. Potential peripheral biological predictors of suicidal behavior in major depressive disorder. Prog Neuropsychopharmacol Biol Psychiatry 2011;35:842-847. DOI
19	Ding Y, Lawrence N, Olie E, Cyprien F, le Bars E, Bonafe A, et al. Prefrontal cortex markers of suicidal vulnerability in mood disorders: a model-based structural neuroimaging study with a translational perspective. Transl Psychiatry 2015;5:e516. DOI
20	Hwang JP, Lee TW, Tsai SJ, Chen TJ, Yang CH, Lirng JF, et al. Cortical and subcortical abnormalities in late-onset depression with history of suicide attempts investigated with MRI and voxel-based morphometry. J Geriatr Psychiatry Neurol 2010;23:171-184. DOI
21	Monkul ES, Hatch JP, Nicoletti MA, Spence S, Brambilla P, Lacerda AL, et al. Fronto-limbic brain structures in suicidal and non-suicidal female patients with major depressive disorder. Mol Psychiatry 2007;12:360-366. DOI
22	Peng H, Wu K, Li J, Qi H, Guo S, Chi M, et al. Increased suicide attempts in young depressed patients with abnormal temporal-parietal-limbic gray matter volume. J Affect Disord 2014;165:69-73. DOI
23	Mann JJ, Arango V, Underwood MD. Serotonin and suicidal behavior. Ann N Y Acad Sci 1990;600:476-484; discussion 484-485. DOI
24	Bellivier F, Chaste P, Malafosse A. Association between the TPH gene A218C polymorphism and suicidal behavior: a meta-analysis. Am J Med Genet B Neuropsychiatr Genet 2004;124B:87-91. DOI
25	Jokela M, Raikkonen K, Lehtimaki T, Rontu R, Keltikangas-Jarvinen L. Tryptophan hydroxylase 1 gene (TPH1) moderates the influence of social support on depressive symptoms in adults. J Affect Disord 2007;100:191-197. DOI
26	Wigner P, Czarny P, Synowiec E, Bijak M, Bialek K, Talarowska M, et al. Association between single nucleotide polymorphisms of TPH1 and TPH2 genes, and depressive disorders. J Cell Mol Med 2018;22:1778-1791. DOI
27	Li D, He L. Further clarification of the contribution of the tryptophan hydroxylase (TPH) gene to suicidal behavior using systematic allelic and genotypic meta-analyses. Hum Genet 2006;119:233-240. DOI
28	Beck AT, Kovacs M, Weissman A. Assessment of suicidal intention: the Scale for Suicide Ideation. J Consult Clin Psychol 1979;47:343-352. DOI
29	Bremner JD, Bolus R, Mayer EA. Psychometric properties of the Early Trauma Inventory-Self Report. J Nerv Ment Dis 2007;195:211-218. DOI
30	Patton JH, Stanford MS, Barratt ES. Factor structure of the Barratt impulsiveness scale. J Clin Psychol 1995;51:768-774. DOI
31	Beck AT, Weissman A, Lester D, Trexler L. The measurement of pessimism: the hopelessness scale. J Consult Clin Psychol 1974;42:861-865. DOI
32	Talairach J, Tournoux P. Co-planar Stereotaxic Atlas of the Human Brain: 3-dimensional Proportional System: an Approach to Cerebral Imaging. G. Thieme. New York: Thieme Medical Publisher; 1988.
33	Abe O, Yamasue H, Kasai K, Yamada H, Aoki S, Inoue H, et al. Voxelbased analyses of gray/white matter volume and diffusion tensor data in major depression. Psychiatry Res 2010;181:64-70. DOI
34	Bell-McGinty S, Butters MA, Meltzer CC, Greer PJ, Reynolds CF 3rd, Becker JT. Brain morphometric abnormalities in geriatric depression: long-term neurobiological effects of illness duration. Am J Psychiatry 2002;159:1424-1427. DOI
35	Feeser M, Schlagenhauf F, Sterzer P, Park S, Stoy M, Gutwinski S, et al. Context insensitivity during positive and negative emotional expectancy in depression assessed with functional magnetic resonance imaging. Psychiatry Res 2013;212:28-35. DOI
36	Liu CH, Ma X, Wu X, Fan TT, Zhang Y, Zhou FC, et al. Resting-state brain activity in major depressive disorder patients and their siblings. J Affect Disord 2013;149:299-306. DOI
37	Connolly CG, Wu J, Ho TC, Hoeft F, Wolkowitz O, Eisendrath S, et al. Resting-state functional connectivity of subgenual anterior cingulate cortex in depressed adolescents. Biol Psychiatry 2013;74:898-907. DOI
38	Guo W, Liu F, Xiao C, Zhang Z, Liu J, Yu M, et al. Decreased insular connectivity in drug-naive major depressive disorder at rest. J Affect Disord 2015;179:31-37. DOI
39	Courtet P, Gottesman, II, Jollant F, Gould TD. The neuroscience of suicidal behaviors: what can we expect from endophenotype strategies? Transl Psychiatry 2011;1. pii:e7.