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http://dx.doi.org/10.7232/IEIF.2011.24.3.187

Development of A Validation System For Automatic Radiopharmaceutical Synthesis Process Using Network Modeling  

Lee, Cheol-Soo (Dept. of Mechanical Engineering, Sogang University)
Heo, Eun-Young (Sogang Institute of Advnaced Technology, Sogang University)
Kim, Jong-Min (Sogang Institute of Advnaced Technology, Sogang University)
Kim, Dong-Soo (Technology Research Center, CSCAM Co Ltd.)
Publication Information
IE interfaces / v.24, no.3, 2011 , pp. 187-195 More about this Journal
Abstract
The automatic radiopharmaceutical module consists of several 2-way valves, couple of syringes, gas supply unit, heating(cooling) unit and sensors to control the chemical reagents as well as to help the chemical reaction. In order to control the actuators of radiopharmaceutical module, the process is tabulated using spread sheet as like excel. Unlike the common program, a trivial error is too critical to allowed in the process because the error can lead to leak the radioactive reagent and to cause the synthesis equipment failure during synthesizing. Hence, the synthesis process has been validated using graphic simulation while the operator checks the whole process visually and undergoes trial and error. The verification of the synthesis process takes a long time and has a difficulty in finding the error. This study presents a methodology to verify the process algebraically while the radiopharmaceutical module is converted to the network model. The proposed method is validated using actual synthesis process.
Keywords
radiopharmaceutical synthesis; network; automated synthetical equipment; process map;
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Times Cited By KSCI : 2  (Citation Analysis)
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1 Oh, S. J., Chi, D. Y., Mosdzianowski, C., Kim, J. Y., Gil, H. S., Kang, S. H., Ryu, J. S., and Moon, D. H. (2005), Fully automated synthesis of [[$^{18}F$]fluoromisonidazole using a conventional [$^{18}F$]FDG module, Nuclear Medicine and Biology, 32(8), 899-905.   DOI   ScienceOn
2 Oh, S. J., Chi, D. Y., Mosdzianowski, C., Gil, H. S., Ryu, J. S., and Moon, D. H. (2007), The automatic production of 16alpha-[$^{18}F$] fluoroestradiol using a conventional [$^{18}F$] FDG module with a disposable cassette system, Applied Radiation and Isotopes, 65(6), 676-681.   DOI   ScienceOn
3 Sung, W. C. (2010), A Study on Temperature Monitoring of a Medical Device with using RFID-Ubiquitous Sensor Network, Master thesis, Hanyang University.
4 Yun, M., Oh, S. J., Ha, H.-J., Ryu, J. S., and Moom, D. (2003), High radiochemical yield synthesis of 3'-deoxy-3'-[$^{18}F$]fluorothymidine using (5'- O-dimethoxytrityl- 2'-deoxy-3'-O-nosyl-beta-D-threopentofuranosyl) thymine and its 3-N-BOC-protected analogue as a labeling precursor, Nuclear Medicine and Biology, 30(2), 151-157.   DOI   ScienceOn
5 Lee, H. J., Jeong, J. M., Lee, Y.-S., Kim, H. W., Chang, Y. S., Lee, D. S., Chung, J.-K., and Lee, M. C. (2007), Quality Control of Residual Solvents in [$^{18}F$]FDG Preparations by Gas Chromatography, Nucl. Med. Mol. Imaging, 41(6), 566-569.
6 Lee, Y. (2009), A comprehensive study on patient flow improvement solutions and their implementation strategies in an outpatient system, Master thesis, KAIST.
7 Min, Y.-B., Kim, D., and Kang, S.-H. (2007), Development of process-centric clinic decision support system, IE Interface, 20(4), 488-497.
8 Oh, S. J., Moon, D. H., Ha, H.-J., Park, S.-W., Hong, M.-K., Park, S.-J., Choi, T. H., Lim, S.-M., Choi, C. W., Knapp, F. F. (Russ) Jr., and Lee, H. K. (2001), Automation of the synthesis of highly concentrated 188Re-MAG3 for intracoronary radiation therapy, Applied Radiation and Isotopes, 54(3), 419-427.   DOI   ScienceOn
9 Oh, S. J., Moon, D. H., Lee, W. W., Park, S.-W., Hong, M.-K., Park, S.-J., Shin, D.-I., and Lee, H. K. (2003), Automated preparation of 188Re-labeled radiopharmaceuticals for endovascular radiation therapy, Applied Radiation and Isotopes, 59(4), 225-230.   DOI   ScienceOn