Browse > Article
http://dx.doi.org/10.4250/jcu.2014.22.3.144

MULTIPLE CARDIOVASCULAR MANIFESTATIONS IN A PATIENT WITH AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE  

Kang, Young Ran (Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine)
Ahn, Jong-Hwa (Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine)
Kim, Kye Hwan (Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine)
Choi, Young Min (Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine)
Choi, Jungwoo (Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine)
Park, Jeong Rang (Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine)
Publication Information
Journal of Cardiovascular Imaging / v.22, no.3, 2014 , pp. 144-147 More about this Journal
Abstract
Autosomal dominant polycystic kidney disease (ADPKD) is a systemic disorder associated with various extrarenal complications. The major cardiovascular complications of ADPKD include valvulopathies and vascular ectasia. A 64-year-old man who was diagnosed with ADPKD seven years previously was admitted to our hospital for heart failure. Pelvic computed tomography revealed multiple variable-sized cysts in both kidneys. Transthoracic echocardiography showed enlargement of the left ventricle and left atrium. Severe mitral regurgitation and moderate aortic regurgitation with annuloaortic ectasia were observed. The left main coronary artery was dilated. The patient had various cardiovascular features associated with ADPKD.
Keywords
Cardiac manifestations; Autosomal dominant polycystic kidney disease; Heart failure;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Leier CV, Baker PB, Kilman JW, Wooley CF. Cardiovascular abnormalities associated with adult polycystic kidney disease. Ann Intern Med 1984;100:683-8.   DOI   ScienceOn
2 Hadimeri H, Lamm C, Nyberg G. Coronary aneurysms in patients with autosomal dominant polycystic kidney disease. J Am Soc Nephrol 1998;9:837-41.
3 Basile C, Lucarelli K, Langialonga T. Spontaneous coronary artery dissection: one more extrarenal manifestation of autosomal dominant polycystic kidney disease? J Nephrol 2009;22:414-6.
4 Helal I, Reed B, Mettler P, Mc Fann K, Tkachenko O, Yan XD, Schrier RW. Prevalence of cardiovascular events in patients with autosomal dominant polycystic kidney disease. Am J Nephrol 2012;36:362-70.   DOI
5 Lumiaho A, Ikaheimo R, Miettinen R, Niemitukia L, Laitinen T, Rantala A, Lampainen E, Laakso M, Hartikainen J. Mitral valve prolapse and mitral regurgitation are common in patients with polycystic kidney disease type 1. Am J Kidney Dis 2001;38:1208-16.   DOI
6 Torres VE, Harris PC. Autosomal dominant polycystic kidney disease: the last 3 years. Kidney Int 2009;76:149-68.   DOI
7 Kim J, Kim SM, Lee SY, Lee HC, Bae JW, Hwang KK, Kim DW, Cho MC, Byeon SJ, Kim KB. A case of severe aortic valve regurgitation caused by an ascending aortic aneurysm in a young patient with autosomal dominant polycystic kidney disease and normal renal function. Korean Circ J 2012;42:136-9.   DOI
8 Paavola J, Schliffke S, Rossetti S, Kuo IY, Yuan S, Sun Z, Harris PC, Torres VE, Ehrlich BE. Polycystin-2 mutations lead to impaired calcium cycling in the heart and predispose to dilated cardiomyopathy. J Mol Cell Cardiol 2013;58:199-208.   DOI
9 Choe SC, Jeon ES, Hwang SD. A case of dilated cardiomyopathy associated with autosomal dominant polycystic kidney disease. J Korean Soc Echocardiogr 2001;9:152-6.
10 Gabow PA. Autosomal dominant polycystic kidney disease. N Engl J Med 1993;329:332-42.   DOI   ScienceOn
11 Perrone RD. Extrarenal manifestations of ADPKD. Kidney Int 1997;51:2022-36.   DOI   ScienceOn
12 Hossack KF, Leddy CL, Johnson AM, Schrier RW, Gabow PA. Echocardiographic findings in autosomal dominant polycystic kidney disease. N Engl J Med 1988;319:907-12.   DOI