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http://dx.doi.org/10.1186/s40824-015-0034-2

Titanium surface modification by using microwave-induced argon plasma in various conditions to enhance osteoblast biocompatibility  

Seon, Gyeung Mi (Cellbiocontrol Laboratory, Department of Medical Engineering, Yonsei University College of Medicine)
Seo, Hyok Jin (Cellbiocontrol Laboratory, Department of Medical Engineering, Yonsei University College of Medicine)
Kwon, Soon Young (Cellbiocontrol Laboratory, Department of Medical Engineering, Yonsei University College of Medicine)
Lee, Mi Hee (Cellbiocontrol Laboratory, Department of Medical Engineering, Yonsei University College of Medicine)
Kwon, Byeong-Ju (Cellbiocontrol Laboratory, Department of Medical Engineering, Yonsei University College of Medicine)
Kim, Min Sung (Cellbiocontrol Laboratory, Department of Medical Engineering, Yonsei University College of Medicine)
Koo, Min-Ah (Cellbiocontrol Laboratory, Department of Medical Engineering, Yonsei University College of Medicine)
Park, Bong Joo (Department of Electrical and Biological Physics and Plasma Bioscience Research Center, Kwangwoon University)
Park, Jong-Chul (Cellbiocontrol Laboratory, Department of Medical Engineering, Yonsei University College of Medicine)
Publication Information
Biomaterials Research / v.19, no.2, 2015 , pp. 76-82 More about this Journal
Abstract
Background: Titanium is a well proven implantable material especially for osseointegratable implants by its biocompatibility and anti-corrosive surface properties. Surface characteristics of the implant play an important role for the evolution of bone tissue of the recipient site. Among the various surface modification methods, plasma treatment is one of the promising methods for enhance biocompatibility. We made microwave-induced argon plasma at atmospheric pressure to improve in titanium surface biocompatibility. Results: Various states of emission spectra from excited species-argon, nitrogen atoms and oxygen atoms were observed. The electron energy band structures are the unique characteristics of atoms and functional groups. Microwave-induced argon plasma treatment changed the titanium surface to be very hydrophilic especially on the 5 s short treatment and 30 s, 90 s long treatment samples that detected by contact angle measurement. MC3T3-E1 attachment and proliferation assay significantly increased in 5 s at short treatment, 30 s, and 90 s at long treatment after 5 days incubation. Conclusions: Result indicated that microwave-induce argon plasma treatment would be an effective method to modify titanium surface for enhancing cell-material interactions.
Keywords
Titanium; Microwave-induced argon plasma; Surface modification; Biocompatibility;
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Times Cited By KSCI : 2  (Citation Analysis)
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