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Swelling Properties for Cross-linking Degree of Hyaluronic Acid Hydrogels  

Kim, Jin Tae (Department of Advanced Material Engineering, Chungbuk National University)
Lee, Deuk Yong (Department of Materials Engineering, Daelim University)
Oh, Yoo Seoung (Department of Prosthetics and Orthotics, Chungbuk Health & Science University)
Bang, Jung Wan (Department of Advanced Material Engineering, Seoul National University)
Hyun, Chang-Yong (Department of Advanced Material Engineering, Seoul National University)
Kim, Tae-Hyung (Department of Radiological Science, Kangwon National University)
Choi, Jae Ha (Department of Advanced Material Engineering, Chungbuk National University)
Publication Information
Biomaterials Research / v.17, no.1, 2013 , pp. 37-40 More about this Journal
Abstract
Hyaluronic acid (HA) hydrogels were crosslinked by dropping of sodium hyaluronate solutions into a solution mixture of divinyl sulfone (DVS) dissolved in 2-methyl-1-propanol. Then cleaning for residual unreacted DVS, and drying at $60^{\circ}C$, 20torr vacuum. The experimental conditions are crosslinking temperature (CLT), crosslinking agent concentration (CAC), respectively. And then parametric studied the morphology, the porosity, the swelling ratio of the hydrogels. The swelling ratio and pore size were decreased as the degree of crosslink was increased. They can be controlled by adjusting the by varying CLT and CAC.
Keywords
hyaluronic acid; hydrogel; swelling properties; porous network;
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