Preparation and Characterization of Hydrophilized Porous Polycaprolactone-encapsulated Alginate Microsphere for the Treatment of Diabetes Mellitus
![]() |
Kim, Eun Ji
(Department of Advanced Materials, Hannam University)
Choi, Soo Jung (Department of Advanced Materials, Hannam University) Kim, Tae Ho (Department of Advanced Materials, Hannam University) Oh, Se Heang (Department of Nanobiomedical Science & WCU Research Center, Dankook University) Lee, Jin Ho (Department of Advanced Materials, Hannam University) |
1 | S. M. Jo, and J. C. Kim, "Trends in the studies of glucoseresponsive drug delivery systems," J. Korean Ind. Eng. Chem., 20, 581-585 (2009). |
2 | A. S. Krolewski, J. H. Warram, and M. B. Freire, "Epidemiology of late diabetic complications. A basis for the development and evaluation of preventive programs," Endocrinol. Metab. Clin. North. Am., 25, 217-242 (1996). DOI ScienceOn |
3 | S. Kizilel, M. Garfinkel, and E. Opara, "The bioartificial pancreas: progress and challenges," Diabetes Technol. Ther., 7, 968-985 (2005). DOI ScienceOn |
4 | M. Evans, "Avoiding hypoglycaemia when treating type 1 diabetes," Diabetes, Obes. Metab., 7, 488-492 (2005). DOI ScienceOn |
5 | G. Orive, A. R. Gascón, R. M. Hernández, M. Igartua, and J. Luis Pedraz, "Cell microencapsulation technology for biomedical purposes: novel insights and challenges," Trends Pharmacol Sci., 24, 207-210 (2003). DOI ScienceOn |
6 | D. J. Han, "Pancreas and islet transplantation in diabetes," J. Korean Med. Assoc., 51, 724-731 (2008). DOI ScienceOn |
7 | H. J. Kim, J. S. Yang, and C. R. Ahn, "Current strategies for successful islet xenotransplantation," J. Korean Soc. Transplant., 23, 214-226 (2009). DOI ScienceOn |
8 | B. J. Hering and C. Ricordi, "Islet transplantation for patients with type I diabetes," Graft, 2, 12-27 (1999). |
9 | H. Uludag, P. D. Vos, and P. A. Tresco, "Technology of mammalian cell encapsulation" Adv. Drug. Deliv. Rev., 42, 29-64 (2000). DOI ScienceOn |
10 | E. S. O'Sullivan, A. Vegas, D. G. Anderson, and G.C. Weir, "Islets transplanted in immunoisolatio devices: A review of the progress and the challenges that remain," Endocr. Rev., 32, 827-844 (2011). DOI |
11 | A. G. Mallett, and G. S. Korbutt. "Alginate modification improves long-term survival and function of transplanted encapsulated islets," Tissue Eng. Part A., 15, 1301-1309 (2009). DOI ScienceOn |
12 | D. Y. Lee, J. H. Nam, and Y. Byun, "Functional and histological evaluation of transplanted pancreatic islets immunoprotected by PEGylation and cyclosporine for 1 year," Biomaterials, 28, 1957-1966 (2007). DOI ScienceOn |
13 | C. Bucke, "Cell immobilization in calcium alginate," Methods Enzymol., 135, 175-179 (1987). DOI |
14 | B. L. Strand, T. L. Ryan, P. In't Veld, B. Kulseng, A. M. Rokstad, G. Skjak-Brek, and T. Espevik, "Poly-l-lysine induces fibrosis on alginate microcapsules via the induction of cytokines," Cell Transplant., 10, 263-275 (2001). |
15 | F. Lim, and A. M. Sum, "Microencapsulated islets as bioartificial endocrine pancreas," Science, 210, 908-910 (1980). DOI |
16 | S. Sakai, T. Ono, H. Ijima, and K. Kawakami, "In vitro and in vivo evaluation of alginate/sol-gel synthesized aminopropyl-silicate/alginate membrane for bioartificial pancreas," Biomaterials, 23, 4177-4183 (2002). DOI ScienceOn |
17 | L. Sikurova and M. Kristekova, "Fluorescence and anisotropy and light-scattering studies of the interaction of insulin with liposomes," J. Fluoresc., 3, 215-217 (1993). DOI ScienceOn |
18 | L. Broens, F. W. Altena, C. A. Smolders, and D. M. Koenhen, "Asymmetric membrane structures as a result of phase separation phenomena," Desalination 32, 33-45 (1980). DOI ScienceOn |
19 | J. H. Lee and S. H. Oh, "MMA/MPEOMA/VSA copolymer as a novel blood-compatible materials: Effect of PEO and negatively charged side chains on protein adsorption and platelet adhesion," J. Biomed. Mater. Res., 60, 44-52 (2002). DOI ScienceOn |
20 | J. H. Lee, H. B. Lee, and J. D. Andrade JD, "Blood compatibility of polyethylene oxide surfaces," Prog. Polym. Sci., 20, 1043-1079 (1995). DOI ScienceOn |
21 | H. S. Park, D. S. Ham, Y. H. You, J. Y. Shin, J. W. Kim, J. H. Jo, O. Y. Kim, G. S. Khang, and K. H. Yoon, "Successful Xenogenic Islet ransplantation with Ba2+-Alginate Encapsulation" Tissue Eng. Regen. Med., 7, 523-530 (2010). |
22 | P. D. Vos, M. M. Faas, B. Strand, and R. Calafiore, "Alginate-based microcapsules for immunoisolation of pancreatic islets," Biomaterials, 27, 5603-5617 (2006). DOI ScienceOn |
23 | E. H. Nafea, A. Marson, L. A. Poole-Warren, and P. J. Martens, "Immunoisolating semi-permeable membranes for cell encapsulation: Focus on hydrogels" Journal of Controlled Release, 154, 110-122 (2011). DOI ScienceOn |
24 | Y. Shirai, K. Hashimoto, and S. Irie, "Formation of effective channels in alginate gel for immobilization of anchorage-dependent animal cells," Appl. Microbiol. Biotechnol., 4, 342-345 (1989). |
25 | X. Cheng, R. Liu and Y. H. He, "A simple method for the preparation of monodisperse protein-loaded microspheres with high encapsulation efficiencies" Eur J Pharm Biopharm., 76, 336-341 (2010). DOI ScienceOn |
26 | K. Wang, Q. Jia, J. Yuan, and S. Li, "A novel, simple method to simulate gelling process of injectable biodegradable in situ forming drug delivery system based on determination of electrical conductivity," Int. J. Pharmaceut.. 404, 176-179 (2011). DOI ScienceOn |
27 | T. H. Kim, S. H. Oh, S. Y. Na, S. Y. Chun, and J. H. Lee, "Effect of biological/physical stimulation on guided bone regeneration through asymmetrically porous membrane," J. Biomed. Mater. Res. Part A, 100A, 1512-1520 (2012). DOI ScienceOn |
28 | D. H. Kim, H. Y. Kim, H. S. Koh, H. E. Park, C. Ahn, and J. Y. Kim, "Alginate Microencapsulation of Cells Using Electrostatic Droplet Generator," J. Korean Soc. Transplant., 24, 101-109 (2010). DOI ScienceOn |
29 | T. Maguire, E. Novik, R. Schloss, and M. Yarmush, "Alginate-PLL microencapsulation: effect on the differentiation of embryonic stem cells into hepatocytes," Biotechnol Bioeng., 93, 581-591 (2006). DOI ScienceOn |
30 | C. B. Woitiski, B. Sarmento, R. A. Carvalho, R. J. Neufeld, and F. Veiga, "Facilitated nanoscale delivery of insulin across intestinal membrane models," Int. J. Pharm., 412, 123-131 (2011). DOI ScienceOn |
![]() |