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http://dx.doi.org/10.14456/apjcp.2016.221/APJCP.2016.17.8.4101

Colorectal Cancer Mortality in Shiraz, Iran  

Dianatinasab, Mostafa (Student Research Committee, Shiraz University of Medical Sciences)
Ghaem, Haleh (Research Center for Health Sciences, Department of Epidemiology, School of Health)
Rezaianzadeh, Abbas (Research Center for Health Sciences, Department of Epidemiology, School of Health)
Hosseini, Seysd Vahid (Colorectal Research Center, Shiraz University of Medical Sciences)
Khazraei, Hajar (Colorectal Research Center, Shiraz University of Medical Sciences)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.17, no.8, 2016 , pp. 4101-4105 More about this Journal
Abstract
Background: Mortality among Iranian patients with colorectal cancer has not been fully examined and the factors associated with their survival are still controversial. This study aimed to determine the mortality rate and its related factors among the patients with colorectal cancer in southwestern regions in Iran. Materials and Methods: This prospective cohort study was conducted on 220 patients with colorectal cancer referred to Fahighi Hospital, Shiraz, Iran from 2009 to 2014. Data were collected from the patients' medical records and were analyzed using Cox regression analysis. Results: Over a median follow-up of 29.3 months, 56 out of the 220 patients (25.5%) died, 32 (14.5%) aged below 40 years, and 45.5% were female. Based on the results of multiple Cox regression analysis, family history of gastrointestinal cancer, stage III, former smoking, type of lesion (fungative and polypoid), and opium use were associated with a greater risk of colorectal cancer mortality (all P<0.05). Conclusions: This cohort study found that the mortality rate of colorectal cancer in Iran is lower than that in European countries. In addition, behavioral and clinical factors were significantly associated with the survival rate. Addressing the related factors would help healthcare providers and physicians provide the best care and improve the survival rate.
Keywords
Mortality; survival rate; colorectal cancer; Cox regression; Iran;
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1 Wang J, Yang Z, Wang L, et al (2003). [Multi-variate regression analysis of clinicopathological characteristics and prognosis of colorectal cancer]. Zhonghua Zhong Liu Za Zhi [Chinese J Oncol], 25, 59-61.
2 Wiseman M (2008). The second World Cancer Research Fund/ American Institute for Cancer Research expert report. Food, nutrition, physical activity, and the prevention of cancer: a global perspective. Proc Nutrition So, 67, 253-6.   DOI
3 Zayeri F, Sheidaei A, Mansouri A (2015). Clustering Asian and North African countries according to trend of colon and rectum cancer mortality rates: an application of growth mixture models. Asian Pac J Cancer Prev, 16, 4115.   DOI
4 Siegel R, DeSantis C, Jemal A (2014a). Colorectal cancer statistics, 2014. CA Cancer J Clinicians, 64, 104-17.   DOI
5 Azadeh S, Moghimi-Dehkordi B, Fatem SR, et al (2008). Colorectal cancer in Iran: an epidemiological study. Asian Pac J Cancer Prev, 9, 123-6.
6 Boyle P, Langman J (2000). ABC of colorectal cancer: Epidemiology. BMJ, 321, 805.   DOI
7 Liang PS, Chen TY, Giovannucci E (2009). Cigarette smoking and colorectal cancer incidence and mortality: Systematic review and meta-analysis. Int J Cancer, 124, 2406-15.   DOI
8 Lynch KL, Ahnen DJ, Byers T, et al (2003). First-degree relatives of patients with advanced colorectal adenomas have an increased prevalence of colorectal cancer. Clin Gastroenterol Hepatol, 1, 96-102.   DOI
9 Sarli L, Michiara M, Sgargi P, et al (2005). The changing distribution and survival of colorectal carcinoma: an epidemiological study in an area of northern Italy. Eur J Gastroenterol Hepatol, 17, 567-72.   DOI
10 Semmens JB, Platell C, Threlfall TJ, et al (2000). A population based study of the incidence, mortality and outcomes in patients following surgery for colorectal cancer in western australia. Aust NZ J Surg, 70, 11-8.   DOI
11 Siegel R, DeSantis C, Virgo K, et al (2012). Cancer treatment and survivorship statistics, 2012. CA Cancer J Clinicians, 62, 220-41.   DOI
12 Siegel R, Ma J, Zou Z, et al (2014b). Cancer statistics, 2014. CA Cancer J Clinicians, 64, 9-29.   DOI
13 Siegel R, Naishadham D, Jemal A (2013). Cancer statistics, 2013. CA Cancer J Clinicians, 63, 11-30.   DOI
14 Siegel RL, Jemal A, Ward EM (2009). Increase in incidence of colorectal cancer among young men and women in the United States. Cancer Epidemiol Biomarkers Prev, 18, 1695-8.   DOI
15 Sinha R, Doval D, Hussain S, et al (2014). Lifestyle and sporadic colorectal cancer in India. Asian Pac J Cancer Prev, 16, 7683-8.
16 Poomphakwaen K, Promthet S, Suwanrungruang K, et al (2014). Risk factors for colorectal cancer in Thailand. Asian Pacific J Cancer Prevent, 16, 6105-9.
17 Haggar FA, Boushey RP (2009). Colorectal cancer epidemiology: incidence, mortality, survival, and risk factors. Clinics Colon Rectal Surg, 22, 191.   DOI
18 Etemad K, Goya M, Ramezani R, et al (2009) Iranian Annual National Cancer Registration Report, . Iran.[In Persian].
19 Fairley TL, Cardinez CJ, Martin J, et al (2006). Colorectal cancer in US adults younger than 50 years of age, 1998-2001. Cancer, 107, 1153-61.   DOI
20 Ferlay J, Shin HR, Bray F, et al (2010). Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer, 127, 2893-917.   DOI
21 Johns LE, Houlston RS (2001). A systematic review and meta-analysis of familial colorectal cancer risk. Am J Gastroenterol, 96, 2992-3003.   DOI
22 Kohler BA, Ward E, McCarthy BJ, et al (2011). Annual report to the nation on the status of cancer, 1975-2007, featuring tumors of the brain and other nervous system. J National Cancer Institute.
23 Newton K, Newman W, Hill J (2012). Review of biomarkers in colorectal cancer. Colorectal Disease, 14, 3-17.
24 Morrison DS, Batty GD, Kivimaki M, et al (2011). Risk factors for colonic and rectal cancer mortality: evidence from 40 years’ follow-up in the Whitehall I study. J Epidemiol Community Health, 2010, 127555.
25 Morrison DS, Parr CL, Lam TH, et al (2013). Behavioural and metabolic risk factors for mortality from colon and rectum cancer: analysis of data from the Asia-Pacific Cohort Studies Collaboration. Asian Pac J Cancer Prev, 14, 1083-7.   DOI
26 Mousavi SM, Gouya MM, Ramazani R, et al (2009). Cancer incidence and mortality in Iran. Ann Oncol, 20, 556-63.
27 O’Connell JB, Maggard MA, Liu JH, et al (2003). Rates of colon and rectal cancers are increasing in young adults. American Surgeon, 69, 866.
28 O’Connell JB, Maggard MA, Livingston EH, et al (2004). Colorectal cancer in the young. American J Surg, 187, 343-8.   DOI
29 O’Connell JB, Maggard MA, Ko CY (2004). Colon cancer survival rates with the new American Joint Committee on Cancer sixth edition staging. J Natl Cancer Inst, 96, 1420-5.   DOI
30 Phipps AI, Baron J, Newcomb PA (2011). Prediagnostic smoking history, alcohol consumption, and colorectal cancer survival. Cancer, 117, 4948-57.   DOI
31 Taheri-Kharameh Z, Noorizadeh F, Sangy S, et al (2014). Factors associated with adherence to colorectal cancer screening among moderate risk individuals in Iran. Asian Pac J Cancer Prev, 16, 8371-5.