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http://dx.doi.org/10.14456/apjcp.2016.175/APJCP.2016.17.8.3817

Clinicopathological Characteristics of Iranian Patients with Lung Cancer: a Single Institute Experience  

Adnan, Khosravi (Medical Oncology, Tobacco Prevention and Control Research Center, Shahid Beheshti University of Medical Sciences)
Zahra, Esfahani-Monfared (Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences)
Sharareh, Seifi (Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences)
Shirin, Karimi (Pathology, Mycobacteriology Research Center, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences)
Habib, Emami (Tobacco Prevention and Control Research Center, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences)
Kian, Khodadad (Internal Medicine, Dalhousie University, Cape Breton Cancer Centre)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.17, no.8, 2016 , pp. 3817-3822 More about this Journal
Abstract
Background: Lung cancer has long been a leading cause of cancer related death in both women and men worldwide. The focus of this study was to review clinicopathological features of Iranian patients diagnosed with lung cancer. Materials and Methods: Clinicopathological data of 1353 primary lung cancer patients diagnosed during 17 years (1997-2014) in the "National Institute of Tuberculosis and Lung Disease" (NRITLD), Tehran, Iran, were retrospectively reviewed. Results: The median age of patients was 60 (mean: 58.95 years, range: 16-99) and adenocarcinoma was the most prevalent pathology (45.2%). Male/female ratio was 3.22 and 57.2% of patients were smokers (men 70.3%, women 15%). The majority (85.3%) were referred in advanced stages (stage IIIB and IV). Conclusions: Although some of our findings are in concordance with other studies in lung cancer but there are some discrepancies particularly in terms of smoking status and median age of Iranian patients. Further clinical and epidemiological studies are warranted to elucidate etiologic and factors other than smoking contributing to development of lung cancer such as environmental exposures or genetic predisposition.
Keywords
Lung cancer; epidemiology; non-small cell; small cell; clinicopathological characteristics;
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1 Gonlugur U, Gonlugur TE, Kaptanoglu M, et al (2008). The changing epidemiological trends for carcinoma of the lung in Turkey. Saudi Med J, 29, 749-53.
2 Greene FL, Page DL, Fleming ID, et al (2002). AJCC Cancer Staging Manual 6th ed. Chicago: Springer-Verlag.
3 Hajmanoochehri F, Mohammadi N, Zohal MA, et al (2014). Epidemiology and clinicopathological characteristics of lung cancer in a teaching hospital in Iran. Asian Pac J Canccer Prev, 15, 2495-500.   DOI
4 Hamid MS, Shameem R, Gafoor K, et al (2015). Non-small-cell lung cancer clinicopathologic features and survival outcomes in asian pacific islanders residing in the United States: A SEER Analysis. J Cancer Epidemiol, 2015, 269304??
5 Higgins K.A, Park D, Lee G.Y, et al (2014). Exercise-induced lung cancer regression: Mechanistic findings from a mouse model. Cancer, 120, 3302-10.   DOI
6 Hoek G, Raaschou-Nielsen O (2014). Impact of fine particles in ambient air on lung cancer. Chin J Cancer, 33, 197-203.
7 Mirtcheva RM, Vazquez M, Yankelevitz DF, et al (2002). Bronchioloalveolar carcinoma and adenocarcinoma with bronchioloalveolar features presenting as ground-glass opacities on CT. Clin Imaging, 26, 95-100.   DOI
8 Mosavi-Jarrahi A, Gouya MM, Ramazani R, et al (2009). Cancer incidence and mortality in Iran. Ann Oncol, 20, 556-63.
9 Nakamura H, Saji H (2013). A worldwide trend of increasing primary adenocarcinoma of the lung. Surg Today. [Epub ahead of print]
10 Navaneelan T, Janz T (2011). Cancer in canada: focus on lung, colorectal, breast and prostate. Statistics Canada Catalogue no. 82-624 - X
11 Wang T, Zhou B, Shi J (1996). Lung cancer in non-smoking Chinese women: a case-control study. Lung Cancer, 14, 93-5.   DOI
12 Surveillance Epidemiology and End Results (2012). SEER stat fact sheets: lung and bronchus. National Cancer Institute. Bethesda, MD. http://seer.cancer.gov/statfacts/html/lungb.html. Accessed March 22, 2012.
13 Tarrahi MJ, Mehrabani D, Khademolhosseini F, et al (2009). Lung cancer occurrence in Southern Iran. J Res Med Sci, 14, 139-40.
14 The World Health Organization histological typing of lung tumours. Second edition (1982). Am J Clin Pathol, 77, 123-36.   DOI
15 Ahmadi J, Khalili H, Jooybar R, et al (2001). Prevalence of cigarette smoking in Iran. Psychol Rep, 89, 339-41.   DOI
16 Almasi Z, Salehiniya H, Amoori N, et al (2016). Epidemiology characteristics and trends of lung cancer incidence in Iran. Asian Pac J Cancer Prev, 17, 557-62.   DOI
17 Thomas L, Doyle LA, Edelman MJ (2005). Lung cancer in women: emerging differences in epidemiology, biology, and therapy. Chest, 128, 370-81.   DOI
18 Thompson CA, Waldhur T, Schernhammer ES, et al (2012). Smoking and lung cancer: current trends in Austria. M.Wien Klin Wochenschr, 124, 493-9.   DOI
19 Wender R, Fontham ET, Barrera E, et al (2013). American cancer society lung cancer screening guidelines. Ca Cancer J Clin, 63, 106-17.   DOI
20 Yu YH, Liao CC, Hsu WH, et al (2011). Increased lung cancer risk among patients with pulmonary tuberculosis: a population cohort study. J Thorac Oncol, 6, 32-7.   DOI
21 Yunesian M, Homayoun-Vash J, Asghari F, et al (2008). Smoking-related respiratory symptoms in Tehran: a crosssectional study. Arch Iran Med, 11, 507-14.
22 Baldini E, Strauss, GM (1997). Women and lung cancer: waiting to exhale. Chest, 112, 229-34.   DOI
23 AL-Hashimi MMY, Wang XJ (2014). Trend analysis of lung cancer incidence rates in ninawa province, iraq, from 2000 to 2010 - decrease and recent stability. Asian Pac J Cancer Prev, 15, 385-90.   DOI
24 American Cancer Society. Cancer Facts & Figures 2015(2015). Atlanta: American Cancer Society; 2015.
25 Australian Institute of Health and Welfare and Cancer Australia. (2011). Lung cancer in Australia: an overview. Cancer series no. 64. Cat. no. CAN 58. Canberra: AIHW.
26 Burns D.M, Anderson C.M, Gray N (2011). Do changes in cigarette design influence the rise in adenocarcinoma of the lung? Cancer Causes Control, 22, 13-22.   DOI
27 Castro CY, Ostrowski ML, Barrios R, et al (2001). Relationship between Epstein-Barr virus and lymphoepithelioma-like carcinoma of the lung a clinicopathologic study of 6 cases and review of the literature. Hum Pathol, 32, 863-72.   DOI
28 Chang JS, Wrensch MR, Hansen HM, et al (2009). Base excision repair genes and risk of lung cancer among San Francisco Bay Area Latinos and African-Americans. Carcinogenesis, 30,78-87.   DOI
29 Houston KA, Henley SJ, Li J, et al (2014). Patterns in lung cancer incidence rates and trends by histologic type in the United States, 2004-2009. Lung Cancer, 86, 22-8.   DOI
30 Hosseini M, Naghan PA, Karimi S, et al (2009). Environmental risk factors for lung cancer in Iran: a case-control study. Int J Epidemiol, 38, 989-96.   DOI
31 Howlader N, Noone AM, Krapcho M, et al (eds) (2014). SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/ csr/1975_2011/, based on November 2013 SEER data submission, posted to the SEER web site, April 2014
32 Iran. Encyclopædia Britannica. Encyclopædia Britannica (2012). Retrieved 8 August 2012.
33 Ou SH, Ziogas A, Zell JA-J (2009). Asian ethnicity is a favorable prognostic factor for overall survival in non-small cell lung cancer (NSCLC) and is independent of smoking status. Thorac Oncol, 4, 1083-93.   DOI
34 Noronha V, Dikshit R, Raut N, et al (2012). Epidemiology of lung cancer in India: Focus on the differences between nonsmokers and smokers: A single-center experience. Indian J Cancer, 49, 74-81.   DOI
35 Oken MM, Creech RH, Tormey DC, et al (1982). Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol, 5, 649-55.   DOI
36 Osawa K, Nakarai C, Uchino K, et al (2012). XRCC3 Gene polymorphism is associated with survival in japanese lung cancer patients. Int J Mol Sci, 13, 16658-67.   DOI
37 Peres J (2013). No clear link between passive smoking and lung cancer. J Natl Cancer Inst, 105, 1844-6.   DOI
38 Perrot M, Licker M, Spiliopoulous A, et al (2000). Sex differences in presentation, management and prognosis of patients with non-small cell lung carcinoma. J Thorac Cardiovasc Surg, 119, 21-6.   DOI
39 Couraud S, Zalcman G, Milleron B, et al (2012). Lung cancer in never smokers - A review. Eur J Cancer, 48, 1299-311.   DOI
40 Chen K-Y, Hsiao C-F, Chang G-C, et al (2015). Estrogen receptor gene polymorphisms and lung adenocarcinoma risk in neversmoking women. J Thorac Oncol, 10, 1413-20.   DOI
41 Dela Cruz CS, Tanoue LT, Matthay RA (2011). Lung cancer: epidemiology, etiology, and prevention. Clin Chest Med, 32, 605-44.   DOI
42 Lam W. K, White N. W, Chan-Yeung M. M( 2004). Lung cancer epidemiology and risk factors in Asia and Africa. int j tuberc lung, 8, 1045-57.
43 Kanematsu T, Hanibuchi M, Tomimoto H, et al (2010) . Epidemiological and clinical features of lung cancer patients from 1999 to 2009 in Tokushima Prefecture of Japan. J Med Investigation, 57, 327-33.
44 Koo LC, Ho JH-C (1990). World wide epidemiological patterns of lung cancer in non-smokers. Int J Epidemiol, 19, 14-2.   DOI
45 Lam WK (2005). Lung cancer in Asian women-the environment and genes. Respirol, 4, 408-17.
46 Lan Q, Hsiung CA, Matsuo K, et al (2012). Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia. Nat Genet, 44, 1330-5.   DOI
47 Dey A, Biswas D, Saha SK, et al (2012). Comparison study of clinicoradiological profile of primary lung cancer cases: An Eastern India experience. Indian J Cancer, 49, 89-95.   DOI
48 Radzikowska E, Glaz P, Roszkowski K (2002). Lung cancer in women: age, smoking, histology, performance status, stage, initial treatment and survival. Population-based study of 20 561 cases. Ann Oncol, 13, 1087-93.   DOI
49 Rezazadeh A, Laber DA, Ghim SJ, et al (2009). The role of human papilloma virus in lung cancer: a review of the evidence. Am J Med Sci, 338, 64-7.   DOI
50 Ruano-Ravina A, Figueiras A, Feire-Garbal-M, et al (2006). Antioxidant vitamins and risk of lung cancer. Curr Pharm Des, 12, 599-613.   DOI
51 Ei-Basmy A (2013). Profile of lung cancer in Kuwait. Asian Pac J Canccer Prev, 14, 6181-4.   DOI
52 Ferlay J, Soerjomataram I, Dikshit R, et al (2012). Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer, 136, 359-86.
53 Freudenheim JL, Rits J, Smith-Worner S (2005). Alcohol consumption and risk of lung cancer: a pooled analysis of cohort studies. Am J Clin Nutr, 82, 657-67.   DOI
54 Fontham ET, Correa P, Reynolds P, et al (1994). Environmental tobacco smoke and lung cancer in non-smoking women. A multicenter study. JAMA, 271, 1752-9.   DOI
55 Garcia M, Jemal A, Ward EM, et al (2007). Global cancer facts & figures 2007.Atlanta, GA: American Cancer Society 2007.
56 Gilliland FD, Hunt WC, Archer VE, et al (2000). Radon progeny exposure and lung cancer risk among non-smoking uranium miners. Health Phys, 79, 365-72.   DOI
57 Goldstraw P, Crowley J, Chansky K, et al (2007). The IASLC Lung Cancer Staging Project: Proposals for the revision of the TNM stage groups in the forthcoming (seventh) edition of the TNM classification of malignant tumours. J Thorac Oncol, 2, 706-14.   DOI
58 Matakidou A, Eisen T, HoulstonBritish RS (2005). Systematic review of the relationship between family history and lung cancer risk. J Cancer, 93, 825-33.   DOI
59 Lortet-Tieulenta J, Soerjomatarama I, Ferlaya J, et al (2014). International trends in lung cancer incidence by histological subtype: Adenocarcinoma stabilizing in men but still increasing in women. Lung Cancer, 84, 13-22.   DOI
60 Malhotra J, Sartori S, Brennan P, et al (2015). Effect of occupational exposures on lung cancer susceptibility: a study of gene-environment interaction analysis. Cancer Epidemiol Biomarkers Prev, 24, 570-9.   DOI
61 Mehrabani D, Tabei SZ, Heydari ST, et al (2008) . Cancer occurrence in Fars Province, Southern Iran. Iranian Red Crescent Med J, 10, 314-22.
62 Minami, H, Yoshimura, M, Tsubota, N, et al (2000). Lung cancer in women: sex-associated differences in survival of patients undergoing resection for lung cancer. Chest, 118, 1603-9.   DOI
63 Sasco A.J, Secretan M.B, Straif K (2004). Tobacco smoking and cancer: a brief review of recent epidemiological evidence. Lung Cancer, 45, 3-9.
64 Sadraei NH, Taghi Riahi (2013) . Idiopathic pulmonary fibrosis in a referral center in Iran: Are patients developing the disease at a younger age? Arch Iranian Med, 16, 177-81.
65 Salim E.I, Jazieh A.R, Moore M.A (2011). Lung cancer incidence in the Arab League countries: risk factors and control. Asian Pac J Cancer Prev, 12, 17-34.
66 Santos-Martines MJ, Curull V, Blanco ML, et al (2005). Lung cancer at a university hospital: epidemiological and histological characteristics of a recent and a historical series. Arch Bronconeumo, l41, 307-12.
67 Shriver SP, Bourdeau HA, Gubish CT, et al (2000). Sex-specific expression of gastrin realizing peptide receptor: relationship to smoking history and risk of cancer. J Natl Cancer Inst, 92, 24-33.   DOI
68 Siegel RL, Naishadham D, Jemal A (2013). Cancer statistics, 2013. CA Cancer, 63, 11-30.   DOI
69 Siegel RL, Miller KD, Jemal A (2015). Cancer statistics, 2015. CA Cancer J, 65, 5-29.   DOI