Antiproliferative Activity of the Methanolic Extract of Withania Somnifera Leaves from Faifa Mountains, Southwest Saudi Arabia, against Several Human Cancer Cell Lines |
Alfaifi, Mohammad Yahya
(Biology Department, Faculty of Science, King Khalid University)
Saleh, Kamel Ahmed (Biology Department, Faculty of Science, King Khalid University) El-Boushnak, Mohammed Atallah (Biology Department, Faculty of Science, King Khalid University) Elbehairi, Serag Eldin I (Biology Department, Faculty of Science, King Khalid University) Alshehri, Mohammed Ali (Biology Department, Faculty of Science, King Khalid University) Shati, Ali Abdullah (Biology Department, Faculty of Science, King Khalid University) |
1 | Al-Abd AM, Al-Abbasi FA, Asaad GF, et al (2013). Didox potentiates the cytotoxic profile of doxorubicin and protects from its cardiotoxicity. Eur J Pharmacol, 718, 361-9. DOI |
2 | Alhazmi MI, Hasan TN, Shafi G, et al (2014). Roles of p53 and caspases in induction of apoptosis in MCF- 7 breast cancer cells treated with a methanolic extract of Nigella sativa seeds. Asian Pac J Cancer Prev, 15, 9655-60. DOI |
3 | Alwadi HM, Baka ZAM (2001). Microorganisms asssociated with Withania somnifera leaves. Microbiological Res, 156, 303-9. DOI |
4 | Dar NJ, Hamid A, Ahmad M (2015). Pharmacologic overview of Withania somnifera, the Indian ginseng. Cell Mol Life Sci, 72, 4445-60. DOI |
5 | Earnshaw WC, Martins LM, Kaufmann SH (1999). Mammalian caspases: structure, activation, substrates, and functions during apoptosis. Ann Rev Biochem, 68, 383-424. DOI |
6 | Halder B, Singh S, Thakur SS (2015). Withania somnifera root extract has potent cytotoxic effect against human malignant melanoma cells. PLoS One, 10, 137498. |
7 | HemaIswarya S, Doble M (2006). Potential synergism of natural products in the treatment of cancer. Phytother Res, 20, 239-49. DOI |
8 | Hengartner MO (2000). The biochemistry of apoptosis. Nature, 407, 770-6. DOI |
9 | Itokawa H, Morris-Natschke S, Akiyama T, et al (2008). Plant-derived natural product research aimed at new drug discovery. J Natural Med, 62, 263-80. DOI |
10 | John J (2014). Therapeutic potential of withania somnifera: a report on phytopharmacological properties. Int J Pharmaceutical Sci Res, 5, 2131+. |
11 | Kumar P, Kushwaha RA (2006). Medicinal evaluation of Withania somnifera (L.) Dunal(Ashwagandha). Asian J Chemistry, 18, 1401-4. |
12 | Kaur K, Rani G, Widodo N, et al (2004). Evaluation of the anti-proliferative and anti-oxidative activities of leaf extract from in vivo and in vitro raised Ashwagandha. Food Chemical Toxicol, 42, 2015-20. DOI |
13 | Kim R, Tanabe K, Uchida Y, et al (2002). Current status of the molecular mechanisms of anticancer drug-induced apoptosis. Cancer Chemotherapy Pharmacol, 50, 343-52. DOI |
14 | Kumar AP, Graham H, Robson C, et al (2011). An overview of anticancer herbal medicines. in 'evidence-based anticancer materia medica', Eds Springer Netherlands, 1-36 |
15 | Paydar M, Wong YL, Moharam BA, et al (2013). In vitro anti-oxidant and anti-cancer activity of methanolic extract from Sanchezia speciosa leaves. Pak J Biol Sci, 16, 1212-5. DOI |
16 | Lee J, Sehrawat A, Singh SV (2012). Withaferin A causes activation of Notch2 and Notch4 in human breast cancer cells. Breast Cancer Res Treat, 136, 45-56. DOI |
17 | Mishra LC, Singh BB, Dagenais S (2000). Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review. Altern Med Rev, 5, 334-46. |
18 | Ouyang L, Luo Y, Tian M, et al (2014). Plant natural products: from traditional compounds to new emerging drugs in cancer therapy. Cell Prolif, 47, 506-15. DOI |
19 | Rahman MA, Mossa JS, Al-Said MS, et al (2004). Medicinal plant diversity in the flora of Saudi Arabia 1: a report on seven plant families. Fitoterapia, 75, 149-61. DOI |
20 | Samadi AK (2013). Ashwagandha: ancient medicine for modern Times. J Ancient Diseases Prev Remedies. |
21 | Shah N, Kataria H, Kaul SC, et al (2009). Effect of the alcoholic extract of Ashwagandha leaves and its components on proliferation, migration, and differentiation of glioblastoma cells: combinational approach for enhanced differentiation. Cancer Sci, 100, 1740-7. DOI |
22 | Skehan P, Storeng R, Scudiero D, et al (1990). New colorimetric cytotoxicity assay for anticancer-drug screening. J Natl Cancer Inst, 82, 1107-12. DOI |
23 | Sultana S, Asif HM, Nazar HM, et al (2014). Medicinal plants combating against cancer--a green anticancer approach. Asian Pac J Cancer Prev, 15, 4385-94. DOI |
24 | Vichai V, Kirtikara K (2006). Sulforhodamine B colorimetric assay for cytotoxicity screening. Nat Protoc, 1, 1112-6. DOI |
25 | Yang Z, Garcia A, Xu S, et al (2013). Withania somnifera root extract inhibits mammary cancer metastasis and epithelial to mesenchymal transition. PLoS One, 8. |
26 | Widodo N, Takagi Y, Shrestha BG, et al (2008). Selective killing of cancer cells by leaf extract of Ashwagandha: components, activity and pathway analyses. Cancer Lett, 262, 37-47. DOI |
27 | Winters M (2006). Ancient medicine, modern use: Withania somnifera and its potential role in integrative oncology. Altern Med Rev, 11, 269-77. |
28 | Yadav B, Bajaj A, Saxena M, et al (2010). In Vitro anticancer activity of the root, stem and leaves of Withania somnifera against various human cancer cell lines. Indian J Pharmaceutical Sci, 72, 659. DOI |
![]() |