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http://dx.doi.org/10.7314/APJCP.2016.17.4.2545

Right-Sided and Left-Sided Colon Cancers are Two Distinct Disease Entities: an Analysis of 200 Cases in Pakistan  

Hussain, Mudassar (Department of Pathology, Shaukat Khanum Memorial Cancer Hospital)
Waqas, Omer (Department of Pathology, Shaukat Khanum Memorial Cancer Hospital)
Hassan, Usman (Department of Pathology, Shaukat Khanum Memorial Cancer Hospital)
Loya, Asif (Department of Pathology, Shaukat Khanum Memorial Cancer Hospital)
Akhtar, Noreen (Department of Pathology, Shaukat Khanum Memorial Cancer Hospital)
Mushtaq, Sajid (Department of Pathology, Shaukat Khanum Memorial Cancer Hospital)
Yusuf, Muhammad Aasim (Department of Internal Medicine, Shaukat Khanum Memorial Cancer Hospital)
Syed, Aamir Ali (Department of Surgery, Shaukat Khanum Memorial Cancer Hospital)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.17, no.5, 2016 , pp. 2545-2548 More about this Journal
Abstract
Background: There is growing evidence that there are differences in histological and genetic characteristics along with clinical behavior between right- and left-sided colon carcinomas. We have compared various parameters of the two types and assessed associations of the results with prognosis in patients in Pakistan. Materials and Methods: We reviewed 200 cases from our institutional database; 100 cases of right-sided and 100 cases of left-sided colon cancer. Parameters including age, gender, TNM stage, histological features and clinical outcome were analyzed. Results: The patients with right-sided colon cancer were significantly older as compared to their counterparts with left-sided cancer. They presented with a lumbar mass rather than symptoms of obstruction and perforation as seen in left-sided colon cancers, and the histology showed higher percentage of poorly differentiated tumors with advanced pT stage. Moreover, Crohn's-like reactions, intra tumoral lymphocyte responses and other poor prognostic factors like lymph vascular invasion and perineural invasion were more common in right-sided cancers. Conclusions: We found that right- and left-sided colon cancers are different from each other in terms of clinical presentation, histology and clinical behavior. Right-sided colon cancers are more aggressive and are associated with poorer clinical outcome as compared to left sided colon cancers in our population.
Keywords
Colon cancer; right-sided; left sided; prognosis; Pakistan;
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